A5010406210- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurological Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Meningioma and schwannoma management
- Aortic aneurysm repair treatments
- T-cell and B-cell Immunology
- Glioma Diagnosis and Treatment
- Neurological Complications and Syndromes
- Neurogenesis and neuroplasticity mechanisms
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Alcoholism and Thiamine Deficiency
University of Yamanashi
2016-2025
Osaka Police Hospital
2019
Stanford University
2009-2013
Stanford Medicine
2009
The University of Tokyo
2008
University of Yamanashi Hospital
2006
Tokyo Teishin Hospital
2002
Shiga Medical Center for Adults
2000
Kyoto University
1987-1996
University of Pennsylvania
1995
Transplantation of neural stem cells (NSCs) offers a novel therapeutic strategy for stroke; however, massive grafted cell death following transplantation, possibly due to hostile host brain environment, lessens the effectiveness this approach. Here, we have investigated whether reprogramming NSCs with minocycline, broadly used antibiotic also known possess cytoprotective properties, enhances survival and promotes neuroprotection in ischemic stroke. harvested from subventricular zone fetal...
Hemoglobin (Hb) released from extravasated erythrocytes is implicated in brain edema after intracerebral hemorrhage (ICH). a major component of blood and potent mediator oxidative stress ICH. Oxidative matrix metalloproteinases (MMPs) are associated with blood–brain barrier (BBB) dysfunction. This study was designed to elucidate whether Hb-induced contributes MMP-9 activation BBB dysfunction vivo. An injection Hb into rat striata induced increased hydroethidine (HEt) signals parallel levels....
Flow diverters (FDs) have been introduced for the management of large or giant cavernous carotid aneurysms (CCAs) in addition to conventional modalities, dramatically changing treatment strategies. The aim this study was examine unruptured large/giant CCAs Japan when FDs were being using a nationwide survey. 540 treated at neurosurgical teaching departments between 2012 and 2016 retrospectively studied. Large equally by parent artery occlusion (PAO), FD, coiling, but occluded mainly PAO. PAO...
About a half of the antierythrocyte autoantibody transgenic (autoAb Tg) mice, in which almost all B cells are detected spleen, lymph nodes, and Peyer's patches, but not peritoneal cavity, suffer from autoimmune hemolytic anemia. The occurrence this disease is strongly linked to production autoAb by activated B-1 Tg mice. In study, we have shown that oral administration lipopolysaccharides (LPS) lamina propria gut as well cavity healthy mice induced symptoms activation enteric LPS found only...
Journal Article Prevention of autoimmune symptoms in autoimmune-prone mice by elimination B-1 cells Get access Masao Murakami, Murakami 1Departments Medical Chemistry, Kyoto UniversityYoshida, Sakyo-ku, 606, Japan Search for other works this author on: Oxford Academic PubMed Google Scholar Hideyuki Yoshioka, Yoshioka 2Geriatric Medicine, Faculty Toshikazu Shirai, Shirai 3Department Pathology, Juntendo University School Medicine2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Takeshi Tsubata, Tsubata...
OBJECTIVE We prospectively investigated the predictive value of diffusion tensor tractography for motor functional outcome in a case series patients with intracerebral hemorrhage. METHODS Diffusion was performed 17 hemorrhage (putamen, nine patients; thalamus, seven combined, one patient) within 5 days after onset. Mean fractional anisotropy (FA) and apparent coefficient (ADC) values along corticospinal tracts at level hematoma were measured bilaterally, ratios (hematoma side/contralateral...
Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a major cause of subsequent morbidity and mortality. Cilostazol, selective inhibitor phosphodiesterase 3, may attenuate cerebral because its antiplatelet vasodilatory effects. A multicenter prospective randomized trial was conducted to investigate the effect cilostazol on vasospasm.Patients admitted with SAH caused by ruptured anterior circulation aneurysm who were in Hunt Kosnik Grades I IV treated clipping within 72...
Medium spiny neurons (MSNs) constitute most of the striatal and are known to be vulnerable ischemia; however, mechanisms vulnerability remain unclear. Activated forms nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase (NOX), which require interaction between cytosolic membrane-bound subunits, among major sources superoxide in central nervous system. Although increasing evidence suggests that NOX has important roles neurodegenerative diseases, its MSN injury after transient global...
Abstract Reactive astrocytes play a pivotal role in the pathogenesis of neurological diseases; however, their functional phenotype and downstream molecules by which they modify disease remain unclear. Here, we genetically increase P2Y 1 receptor (P2Y1R) expression, is upregulated reactive several diseases, male mice to explore its function molecule. This astrocyte-specific P2Y1R overexpression causes neuronal hyperexcitability increasing both astrocytic Ca 2+ signals. We identify...
Recently, intraoperative fluorescence video angiography using indocyanine green (ICG) has been widely used in aneurysm surgery. This is a simple and useful method to confirm complete occlusion of the lumen preservation blood flow arteries around aneurysm. However, observation field ICG limited under microscope, making it difficult behind parent or The authors developed new technique endoscopic assess perforating hidden by endoscope emits excitation light with wavelength approximately 800 nm,...
Previous studies have shown that intraparenchymal transplantation of neural stem cells ameliorates neurological deficits in animals with intracerebral hemorrhage. However, hemoglobin the host brain environment causes massive grafted cell death and reduces effectiveness this approach. Several preconditioning induced by sublethal hypoxia can markedly improve tolerance treated subjects to more severe insults. Therefore, we investigated whether hypoxic enhances resilience hemorrhagic stroke...
BACKGROUND: To visualize blood flow in the arteries and aneurysm during surgery, intravenous fluorescence videoangiography has been used. However, image contrast with this procedure is diminished by repeated study because dye remains for about 10 minutes after injection. OBJECTIVE: determine optimal concentration to clarify usefulness of fluorescein intra-arterial METHODS: In pilot study, sodium dissolved at various concentrations was illuminated excitation light, detected cameras. The...
Extracellular ATP, which is released from damaged cells after ischemia, activates P2 receptors. P2Y 1 receptors (P2Y R) have received considerable attention, especially in astrocytes, because their activation plays a central role the regulation of neuron-to-glia communication. However, functions or even existence R microglia remain unknown, despite fact that many microglial are involved several brain diseases. Herein, we demonstrate presence and functional capability to provide...
A reproducible transient global cerebral ischemia (tGCI) mouse model has not been fully established. Although striatal neurons and white matter are recognized to be vulnerable ischemia, their injury after tGCI in mice elucidated. The purpose of this study was evaluate injuries C57BL/6 mice, develop a model. Male were subjected by bilateral common carotid artery occlusion (BCCAO). Mice whose cortical blood flow BCCAO decreased less than 13% the pre-ischemic value used. Histological analysis...
Previous studies have shown that intraparenchymal transplantation of neural stem cells (NSCs) ameliorates neurologic deficits in animals with intracerebral hemorrhage (ICH). However, massive grafted cell death after transplantation, possibly caused by a hostile host brain environment, lessens the effectiveness this approach. We focused on effect oxidative stress against NSCs and hypothesized conferring antioxidant properties to transplanted may overcome their enhance neuroprotection ICH....
Large or giant paraclinoid aneurysms have been treated with various strategies, including clipping, coiling, and parent artery occlusion (PAO). In addition, flow diverters (FDs) introduced for the management of these aneurysms. The aim this study was to examine unruptured large/giant in Japan when FDs were being by a nationwide survey. A total 576 between January 2012 December 2016 retrospectively studied. Half large coiling (50.3%), whereas occluded mainly PAO (51.4%). high nearly complete...
Malignant glioma progresses rapidly and shows poor prognosis, but clinically applicable blood plasma-based biochemical tumor markers remain lacking. This study aimed to develop a diagnostic system using probe electrospray ionization mass spectrometry (PESI-MS) machine-learning logistic regression model detect plasma changes at various time points in murine model.
OBJECTIVE Plaque composition, but not degree of stenosis, may play a key role in the development recurrent ischemic events patients with symptomatic mild (< 50%) carotid artery stenosis. This multicenter prospective cohort study was aimed to determine their clinical and radiological features evaluate benefits endarterectomy (CEA) for them. METHODS included 124 cerebrovascular or retinal ipsilateral Best medical therapy (BMT) administered all participants. CEA stenting implemented at each...
Although the endovascular approach has emerged as first-choice treatment for basilar bifurcation aneurysms these days, there are situations where direct surgery remains necessary. Among several surgical approaches, subtemporal trans-tentorial can be adapted low-positioned projecting posteriorly. Since surgeons observe aneurysm from a lateral perspective in this approach, posterior clinoid process (PCP) does not usually obstruct field, and clinoidectomy been reported to date. We present first...
A 17-year-old Japanese woman diagnosed with granulomatosis polyangiitis (GPA) and was treated immunotherapy suddenly developed an impaired consciousness, left hemiplegia, conjugate eye deviation to the right. Magnetic resonance imaging showed acute cerebral infarction in right striatum middle artery (MCA) occlusion. As her GPA had worsened recently, intravenous methylprednisolone (IVMP) started. Immediately after IVMP started, recanalization of MCA detected on repeat angiography. Aspirin...
BACKGROUND AND IMPORTANCE: Idiopathic spinal cord herniation through a defect in the ventral dura mater is rare and typically results progressive myelopathy. Various surgical procedures to release tethered can prevent progression of myelopathy; however, optimal procedure has not yet been established. We describe techniques using endoscopic assistance minimize manipulation. CLINICAL PRESENTATION: A 60-year-old woman presented with Brown-Séquard syndrome. Magnetic resonance imaging...
Activation of the NADPH oxidase subunit, NOX2, and increased oxidative stress are associated with neuronal death after cerebral ischemia reperfusion. Inhibition NOX2 by casein kinase 2 (CK2) leads to survival, but mechanism is unknown. In this study, we show that in copper/zinc-superoxide dismutase transgenic (SOD1 Tg) mice, degradation CK2α CK2α' dephosphorylation CK2β against were markedly reduced compared wild-type (WT) mice underwent middle artery occlusion. CK2 pharmacologically or...