A5005081144- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Blood groups and transfusion
- Blood properties and coagulation
- Blood transfusion and management
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Blood donation and transfusion practices
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood disorders and treatments
- Renal Diseases and Glomerulopathies
- Catalysis and Hydrodesulfurization Studies
- Lipoproteins and Cardiovascular Health
- Cardiovascular Issues in Pregnancy
- Pancreatic function and diabetes
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Proteoglycans and glycosaminoglycans research
- Complement system in diseases
- Glycosylation and Glycoproteins Research
Université de Strasbourg
2015-2024
Inserm
2015-2024
Établissement Français du Sang
2014-2023
Laboratoire de Neurosciences Cognitives et Adaptatives
2017-2021
Centre National de la Recherche Scientifique
1982-2021
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021
Université Paris-Sud
2021
Institut Curie
2021
Université Paris-Saclay
2021
Institut Pluridisciplinaire Hubert Curien
2021
The liver can regenerate its volume after major tissue loss. In a mouse model of regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation liver. Platelets are carriers serotonin blood. thrombocytopenic mice, agonist reconstituted proliferation. expression 5-HT2A and 2B subtype receptors increased hepatectomy. Antagonists inhibited regeneration. Liver regeneration was also blunted mice lacking tryptophan hydroxylase 1, which is...
ADP is a key agonist in hemostasis and thrombosis. ADP-induced platelet activation involves the purinergic P2Y1 receptor, which responsible for shape change through intracellular calcium mobilization. This process also depends on an unidentified P2 receptor (P2cyc) that leads to adenylyl cyclase inhibition promotes completion amplification of response. P2Y1-null mice were generated define role determine whether P2cyc distinct from P2Y1. These are viable with no apparent abnormalities...
Summary ADP plays a crucial role in haemostasis and thrombosis its receptors are potential targets for antithrombotic drugs. Two G-protein coupled P2 contribute to platelet aggregation: the P2Y1 receptor initiates aggregation through mobilisation of calcium stores, while more recently identified P2Y12 adenylyl cyclase inhibition is essential full response stabilisation aggregates. The latter defective certain patients with selective congenital deficiency ADP. It also target drug clopidogrel...
Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity its relation to pathophysiology are unclear. Here, we show that microglia transform into a neuroprotective phenotype via downregulation P2Y1 purinergic receptor. TBI initially caused microglial activation in core, followed by astrogliosis peri-injured region formation astrocyte scar. Equivalent changes were observed vitro after injury. This change resulted from...
Coronary artery thrombosis is often initiated by abrupt disruption of the atherosclerotic plaque and activation platelets on subendothelial layers in disrupted plaque. The extracellular matrix protein collagen most thrombogenic constituent layer; therefore, a selective inhibition pathway may provide strong antithrombotic protection while preserving other platelet functions. Here we demonstrate that treatment mice with monoclonal antibody against activating receptor glycoprotein VI (GPVI;...
© 1997 Federation of European Biochemical Societies.
The capsaicin receptor transient potential V1 (TRPV1; also known as vanilloid 1) is a sensory neuron-specific ion channel that serves polymodal detector of pain-producing chemical and physical stimuli. It has been reported extracellular ATP potentiates the TRPV1 currents evoked by or protons reduces temperature threshold for its activation through metabotropic P2Y receptors in PKC-dependent pathway, suggesting could trigger sensation pain at normal body presence ATP. Here, we show...
The P2X1 receptor is a fast ATP-gated cation channel expressed in blood platelets, where its role has been difficult to assess due rapid desensitization and the lack of pharmacological tools. In this paper, we have used P2X1−/− wild-type mouse treated with apyrase prevent desensitization, demonstrate function response thrombogenic stimuli. vitro, collagen-induced aggregation secretion P2X1-deficient platelets was decreased, as adhesion thrombus growth on collagen-coated surface, particularly...
We have previously shown that the extracellular nucleoside triphosphate-hydrolyzing enzyme NTPDase2 is highly expressed in situ by stem/progenitor cells of two neurogenic regions adult murine brain:the subventricular zone (type B cells) and dentate gyrus hippocampus (residual radial glia). explored possibility multipotent neural stem express nucleotide receptors investigated their functional properties vitro. Neurospheres cultured from mouse SVZ presence epidermal growth factor fibroblast 2...
Citrate is the preferred anticoagulant for blood collection, as EDTA damages platelets and heparin modifies their function (1). allows rapid generation of platelet-rich plasma (PRP), with a high yield platelets; however, this method has certain disadvantages. In particular, PRP preparation limited stability (no longer than 2 h) contains proteins, including enzymes. addition, human (PRP) prepared from collected into trisodium citrate (3.8% w/v) depressed ionic calcium concentration, which can...