A5028562352- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Adipose Tissue and Metabolism
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Ovarian cancer diagnosis and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Nitric Oxide and Endothelin Effects
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Bariatric Surgery and Outcomes
- Maternal and Perinatal Health Interventions
- Gestational Trophoblastic Disease Studies
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Inflammatory mediators and NSAID effects
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
Mie University
2005-2024
Rakuwakai Otowa Hospital
2013-2024
Japan Atomic Energy Agency
2023-2024
National Cancer Center Hospital East
2016
Mie University Hospital
2016
Iwate Medical University
2016
Okayama University Hospital
2016
Aichi Cancer Center
2016
New York University Press
2011
Cambridge University Press
2011
Preeclampsia (PE) is a hypertensive disorder, which develops in late pregnancy and usually associated with placental hypoxia dysfunction. We have recently demonstrated that leptin novel placenta-derived hormone humans suggested its significance human (see Ref. 19). To explore the changes production placenta PE, we measured plasma level messenger RNA expression pregnant women PE. Plasma levels preeclamptic were elevated significantly, compared gestational age- body mass index-matched normal...
The mechanism for decreased insulin sensitivity in pregnant women is not fully clarified. Resistin, a novel peptide hormone, specifically expressed the adipose tissue and decreases rodents. In present study, we demonstrate resistin gene expression human placental tissue, mainly trophoblastic cells. term was more prominent than seen first trimester chorionic tissue. contrast rather weak remained unchanged by pregnancy. Thus, newly isolated hormone humans which may modulate during
Excess or loss of body fat can be associated with infertility, suggesting that adequate mass is essential for proper reproductive function. Leptin an adipocyte-derived hormone involved in the regulation food intake and energy expenditure, its synthesis secretion are markedly increased obesity. Short-term administration leptin accelerates onset puberty normal mice corrects sterility leptin-deficient ob/ob mice. These findings suggest a role as endocrine signal between depots axis, but effect...
Diacylglycerol lipase activity has been demonstrated in human fetal membranes and decidua vera tissues.The specific of the enzyme is highest microsomal fraction tissue.The acylester bond at sn-1 position 1,2-diacyl-sn-glycerol hydrolyzed followed by release fatty acid sn-2 position.The diacylglycerol present tissue hydrolyzes preferentially a containing an arachidonoyl group position.Monoacylglycerol was also these monoacylglycerol significantly greater than that catalyzed hydrolysis...
Phospholipase C, phospholipase A2, and diacylglycerol lipase activities in human amnion, chorion laeve, uterine decidua vera tissues obtained early late gestation were examined. The specific of C amnion at 13–17 38–41 weeks 1.1 6.3 μmol • h−1 mg−1 protein, respectively. A similar fold-increase the activity A2 tissue from gestational periods was also observed (3.5 to 12.6 nmol protein). In gestation, greater than either laeve or tissues. Diacylglycerol demonstrated these three No change any...
Human uterine cervical tissue is composed mainly of fibroblast cells and the extracellular matrix in which collagen types I III predominate. It hypothesized that these collagens are degraded by metalloproteinases (MMPs) initial step ripening during parturition. Among MMPs, MMP-1, -8 -13 have substrate selectivity for III. In present study, we examined regulation MMP-1 secretion from human cervix. Immunohistochemistry detected strong staining but not MMP-8 or -13, stromal pregnant The...
There are already 12 reports of women treated by chemotherapy for epithelial ovarian cancer during pregnancy. However, most cases received single cisplatin or cisplatin-based regime, and only four carboplatin-containing chemotherapy. We report the case a woman with single-agent carboplatin The patient underwent bilateral salpingo-oophorectomy at 18 weeks gestation was diagnosed as having stage IC undifferentiated carcinoma. She courses (area under curve = 6.0) pregnancy without severe...
To compare pregnancy outcomes between women with gestational diabetes mellitus (GDM) diagnosed early and late in Japan.
Endothelin (ET), a novel vasoconstrictor peptide containing three isopeptides [ET-1, ET-2, and ET-3 (ETs)], has various biological effects including vasoconstriction, mitogenesis, steroidogenesis. We examined the ET-1-like immunoreactivity level in porcine follicular fluid culture medium of granulosa cells by RIA. The ET was 9.4-14.2 pg/ml. These levels were within 0.42 to 0.62-fold poicine plasma (22.7 ± 3.1 pg/ml) (mean SE). detected with without LH treatment at concentration 56 9.3 4.9...
Leptin is a satiety hormone secreted from the adipose tissue and human placenta. We previously demonstrated that severe preeclampsia up-regulated leptin mRNA expression in placenta elevated maternal plasma concentrations. Preeclampsia frequently related to generation of small for gestational age (SGA) infant especially cases with preeclampsia. However, it still controversial whether increase levels associated fetal growth restriction without complication Therefore, aim present study was...
The plasma levels of 20 free amino acids in the umbilical veins and arteries 8 premature (29–36 weeks gestation) 16 mature (38–42 newborn infants were measured at delivery. In infants, most significantly higher vein than artery. Only glutamic acid was lower 7 (Ala, Lys, Leu, Val, He, Phe His) 4 (Glu, Gly, Ser Om) These results indicate that relative contribution individual to placental supply nitrogen human fetus discernibly changes with increasing fetal age during last trimester gestation.
The infiltration of classically activated macrophages (M1) and alternatively (M2) in subcutaneous adipose tissue (SAT) parametrial (PAT) was analyzed to investigate whether local inflammatory change occurs late pregnancy. C57B L /6N female mice at 6 weeks age were fed a normal chow diet for 4 prior mating 10 sampled on day 17 serum levels adipokines biochemical markers measured using ELISA enzymatic methods. identification M1 M2 by double immunofluorescence with anti-F4/80 anti-CD11c...
Evidence has emerged that undernutrition in utero is a risk factor for cardiovascular disorders adulthood, along with genetic and environmental factors. Recently, the local expression of angiotensinogen related bioactive substances been demonstrated to play pivotal role cardiac remodeling, i.e. fibrosis hypertrophy. The aim present study was clarify possible involvement angiotensin system fetal undernutrition-induced disorders. We developed mouse model by maternal food restriction, which...
Embryonic stem cells (ESCs) of nonhuman primates are important for research into human gametogenesis because similarities between the embryos and fetuses those humans. Recently, formation germ from mouse ESCs in vitro has been reported. In this study, we established cynomolgus monkey ES cell lines (cyESCs) attempted to induce their differentiation obtain further information on development primate by observing markers specific cells. Three cyESCs were newly confirmed be pluripotent. When...