A5064352051- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Nutritional Studies and Diet
- Tracheal and airway disorders
- Diabetes Treatment and Management
- Coronary Interventions and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
National Cerebral and Cardiovascular Center
2016-2025
Health Information Management
2022-2025
Osaka National Hospital
2024
Saitama International Medical Center
2009-2024
Tohoku University Hospital
2023
Tohoku University
2023
Fukuoka Hospital
2022
Kishokai Medical Corporation
2022
Shimane University
2022
Saiseikai Fukuoka General Hospital
2022
Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases general. However, precise mechanism(s) responsible for coronary remains to be elucidated, and we examined molecular genetics spasm.We searched possible mutations endothelial nitric oxide synthase (eNOS) gene patients with spasm. In this study, demonstrate existence 3 linked 5'-flanking region eNOS (T-786-->C, A-922-->G, T-1468-->A). The incidence was significantly greater than control group (P<0.0001)....
Revisions 1. CQs and Systematic Review (SR)In the subsections on dyslipidemia in assessment of risk factors, absolute ASCVD, lipid management targets as well drug therapy diet improving lifestyle habits, we created performed an SR based MINDS method.For our SR, essentially chose literature published before end 2015. Calculation Absolute RiskFollowing 2012 version, has been using calculation described this set guidelines.The NIPPON DATA80, which was used to calculate result baseline surveys...
Abstract —Essential hypertension has a genetic basis. Accumulating evidence, including findings of elevation arterial blood pressure in mice lacking the endothelial nitric oxide synthase (eNOS) gene, strongly suggests that alteration NO metabolism is implicated hypertension. There are, however, no reports indicating polymorphism eNOS gene associated with essential We have identified missense variant, Glu298Asp, exon 7 and demonstrated it both coronary spastic angina myocardial infarction. To...
Background— Type-1 long-QT syndrome (LQTS) is caused by loss-of-function mutations in the KCNQ1-encoded I Ks cardiac potassium channel. We evaluated effect of location, coding type, and biophysical function KCNQ1 on clinical phenotype this disorder. Methods Results— investigated course 600 patients with 77 different 101 proband-identified families derived from US portion International LQTS Registry (n=425), Netherlands’ (n=93), Japanese (n=82). The Cox proportional hazards survivorship model...
Coronary artery embolism (CE) is recognized as an important nonatherosclerotic cause of acute myocardial infarction. Its prevalence, clinical features, and prognosis remain insufficiently characterized.We screened 1776 consecutive patients who presented with de novo infarction between 2001 2013. CE was diagnosed based on criteria encompassing histological, angiographic, other diagnostic imaging findings. The characteristics, treatment strategies, in-hospital outcomes, long-term risk...
Aim: The Framingham risk score (FRS) is one of the standard tools used to predict incidence coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. purpose this was develop new prediction algorithms in manner FRS, and compare them with original FRS. Methods: Our were based on large population-based cohort (Suita study). comprised 5,521 healthy Japanese. They followed-up 11.8 years average, 213 cases CHD observed. Multiple Cox...
<h3>Importance</h3> Whether recent changes in demographic characteristics and therapeutic technologies have altered stroke outcomes remains unknown. <h3>Objective</h3> To determine secular initial neurological severity short-term functional of patients with acute by sex using a large population. <h3>Design, Setting, Participants</h3> This nationwide, hospital-based, multicenter, prospective registry cohort study used the Japan Stroke Data Bank included who developed from January 2000 through...
Risk stratification in patients with type 3 long-QT syndrome (LQT3) by clinical and genetic characteristics effectiveness of β-blocker therapy has not been studied previously a large LQT3 population.The study population included 406 51 sodium channel mutations; 391 were known to be event free during the first year life focus our study. Clinical, electrocardiographic, parameters acquired for from 7 participating registries. Cox regression analysis was used evaluate independent contribution...
Background In cardiac hypertrophy, both excessive enlargement of myocytes and progressive interstitial fibrosis are well known to occur simultaneously. the present study, investigate interaction between ventricular (MCs) nonmyocytes (NMCs), mostly fibroblasts, during cardiocytes we examined change in cell size gene expression atrial natriuretic peptide (ANP) brain (BNP) cultured MCs as markers for hypertrophy neonatal rat culture system. Methods Results The significantly increased MC-NMC...
Background— Reduced cardiac sodium current slows conduction and renders the heart susceptible to ventricular fibrillation. Loss of function mutations in SCN5A , encoding channel, are one cause Brugada syndrome, associated with slow a high incidence fibrillation, especially Asians. In this study, we tested hypothesis that an promoter polymorphism common Asians modulates variability conduction. Methods Results— Resequencing 2.8 kb identified haplotype variant consisting 6 polymorphisms...
Background— Genetic predisposition to life-threatening cardiac arrhythmias such as congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden death in young adults children. Recently, mutations calmodulin ( CALM1 , CALM2 ) have been associated with severe forms LQTS CPVT, occurring very early life. Additional mutation-positive cases are needed discern genotype–phenotype correlations mutations. Methods Results— We...
Background: The genotype-phenotype correlation of SCN5A mutations as a predictor cardiac events in Brugada syndrome remains controversial. We aimed to establish registry limited probands, with long follow-up period, so that the can be examined without patient selection bias. Methods: This multicenter enrolled 415 probands (n=403; men, 97%; age, 46±14 years) diagnosed whose gene was analyzed for mutations. Results: During mean period 72 months, overall event rate 2.5%/y. In comparison ( (–),...
Background:Since cardiovascular disease accounts for one-quarter of deaths in the Japanese population, we developed a nationwide database using administrative case-mix Diagnostic Procedure Combination (DPC) system (ie, theJapaneseRegistryOfAll cardiac and vascularDiseases (JROAD)-DPC) to reveal current status medicine Japan.
Summary Previous studies have identified various factors related to masticatory performance. This study was aimed investigate variations and impacts of performance among different occlusal support areas in general urban population Japan. A total 1875 Japanese subjects (mean age: 66·7 years) were included the Suita study. Periodontal status evaluated using Community Index (CPI). The number functional teeth (OSA) recorded, latter divided into three categories perfect, decreased lost OSA based...
Aim: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events patients with type 2 diabetes were little known on randomized controlled trial.Methods: Thirty-eight diabetic (21 men 17 women) assigned either the group (n=21) or control without training (n=17) by simple randomization. was scheduled for aerobic resistance programs 3 months. After 3-month, we investigated endothelial function, insulin resistance, adipocytokines...
There are limited data about the optimal anti-thrombotic therapy for preventing embolism while minimizing bleeding events in patients with first acute myocardial infarction (AMI) complicated by left ventricular thrombus (LVT). Among 2301 consecutive AMI hospitalized between 2001 and 2014, we studied 1850 who discharged alive to investigate clinical characteristics, incidence of systemic (SE), association anticoagulation embolic or events. Left was diagnosed echocardiography,...