A5079640536- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- RNA regulation and disease
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Adrenal and Paraganglionic Tumors
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Lipid metabolism and disorders
- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Retinal Diseases and Treatments
- Bariatric Surgery and Outcomes
- Hormonal Regulation and Hypertension
Chiba University
2016-2025
Chiba University Hospital
2016-2025
Walter and Eliza Hall Institute of Medical Research
2023-2024
International University of Health and Welfare
2019-2021
Japanese Red Cross Narita Hospital
2019
Osaka University Hospital
2018
Yokosuka Kyosai Hospital
2015
Institute for Atherosclerosis Research
2007-2014
Diabetes Australia
2011
RIKEN Center for Integrative Medical Sciences
2010
Obesity is a global health challenge with few pharmacologic options. Whether adults obesity can achieve weight loss once-weekly semaglutide at dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed.
Revisions 1. CQs and Systematic Review (SR)In the subsections on dyslipidemia in assessment of risk factors, absolute ASCVD, lipid management targets as well drug therapy diet improving lifestyle habits, we created performed an SR based MINDS method.For our SR, essentially chose literature published before end 2015. Calculation Absolute RiskFollowing 2012 version, has been using calculation described this set guidelines.The NIPPON DATA80, which was used to calculate result baseline surveys...
We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), key enzyme in conversion of glutamine to glutamate, and thereby regulator glutathione (GSH) synthesis energy production. GLS2 expression is induced response DNA damage or oxidative stress p53-dependent manner, associates with the promoter. Elevated facilitates metabolism lowers intracellular reactive oxygen species (ROS) levels, resulting an overall decrease oxidation as determined by measurement 8-OH-dG...
High triglyceride levels are associated with increased cardiovascular risk, but whether reductions in these would lower the incidence of events is uncertain. Pemafibrate, a selective peroxisome proliferator–activated receptor α modulator, reduces and improves other lipid levels.
Among the various atherosclerotic cardiovascular diseases (CVDs), these guidelines primarily deal with cerebrovascular disease, peripheral arterial disease (PAD) and coronary artery (CAD), which occur in association atherosclerosis is closely related to dyslipidemia.
To explore changes in body weight and cardiometabolic risk factors after treatment withdrawal the STEP 1 trial extension.STEP (NCT03548935) randomized 1961 adults with a mass index ≥ 30 kg/m2 (or 27 weight-related co-morbidity) without diabetes to 68 weeks of once-weekly subcutaneous semaglutide 2.4 mg (including 16 dose escalation) or placebo, as an adjunct lifestyle intervention. At week 68, treatments intervention) were discontinued. An off-treatment extension assessed for further year...
Abstract Metabolic dysfunction is a primary feature of Werner syndrome (WS), human premature aging disease caused by mutations in the gene encoding (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but underlying mechanisms are not understood, and whether deficit can be targeted for therapeutic intervention has been determined. Here we report impaired mitophagy depletion NAD + , fundamental ubiquitous molecule, patient samples invertebrate models. WRN regulates...
Chronic inflammation due to obesity contributes the development of metabolic diseases, autoimmune and cancer. Reciprocal interactions between systems immune cells have pivotal roles in pathogenesis obesity-associated although mechanisms regulating inflammatory diseases are still unclear. In present study, we performed transcriptional profiling memory phenotype CD4 T high-fat-fed mice identified acetyl-CoA carboxylase 1 (ACC1, gene product Acaca) as an essential regulator Th17 cell...
Abstract To fulfil the bioenergetic requirements for increased cell size and clonal expansion, activated T cells reprogramme their metabolic signatures from energetically quiescent to activated. However, molecular mechanisms essential components controlling reprogramming in are not well understood. Here, we show that mTORC1–PPARγ pathway is crucial fatty acid uptake programme CD4 + cells. This required full activation rapid proliferation of naive memory PPARγ directly binds induces genes...
Statement1. Familial hypercholesterolemia (FH) is an autosomal hereditary disease with the 3 major clinical features of hyper-LDL-cholesterolemia, premature coronary artery and tendon skin xanthomas. As there a considerably high risk (CAD), in addition to early diagnosis intensive treatment, family screening (cascade screening) required (Recommendation level A) 2. For FH, at least 2 following criteria should be satisfied:① LDL-C ≥180 mg/dL, ② Tendon/skin xanthomas, ③ History FH or CAD within...
Background: Evidence regarding the primary prevention of coronary artery disease events by low-density lipoprotein cholesterol (LDL-C) lowering therapy in older individuals, aged ≥75 years, is insufficient. This trial tested whether LDL-C–lowering with ezetimibe useful for cardiovascular patients. Methods: multicenter, prospective, randomized, open-label, blinded end-point evaluation conducted at 363 medical institutions Japan examined preventive efficacy patients elevated LDL-C without...
To assess the efficacy and safety of K-877 (Pemafibrate), a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα) that possesses unique PPARα activity selectivity, compared with placebo fenofibrate in dyslipidaemic patients high triglyceride (TG) low high-density lipoprotein cholesterol (HDL-C) levels.This study was double blind, placebo-controlled, parallel-group 12-week clinical trial. The randomized 224 to 0.025, 0.05, 0.1, 0.2 mg BID, 100 QD, or (1:1:1:1:1:1)...
Abstract Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been previously implicated in activities consistent with tumor suppression. Here we generated Gls2 knockout (KO) mice that develop late-occurring B-cell lymphomas hepatocellular carcinomas (HCC). Further, KO subjected to the hepatocarcinogenic Stelic Animal Model (STAM) protocol produce larger HCC tumors than seen wild-type (WT) mice. GLS2 shown promote ferroptosis, form cell death characterized by...
To identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study Obesity (JASSO) advocated concept "obesity disease." Here we summarize definition, criteria, and core concepts management obesity disease based on JASSO's latest guideline. JASSO defines as excessive fat storage in adipose tissue associated with BMI ≥25 kg/m2. The threshold is low compared to Western countries given that Japanese individuals tend develop...
The Src homology 2 (SH2) domain-containing Shc proteins p52shc and p46shc become phosphorylated upon activation of several tyrosine kinases are implicated in mitogenic signal transduction. Ligand stimulation the platelet-derived growth factor (PDGF) beta-receptor leads to autophosphorylation residues, which is known mediate interactions with SH2 signaling molecules. In this study, we have characterized interaction between PDGF Shc. coprecipitation immunoprecipitates was dependent on PDGF-BB....