Yoshihiro Onouchi
A5072467149- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Streptococcal Infections and Treatments
- Mechanical Circulatory Support Devices
- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- COVID-19 epidemiological studies
- Global Cancer Incidence and Screening
- Asthma and respiratory diseases
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- COVID-19 diagnosis using AI
- Cardiovascular Function and Risk Factors
- Immunotherapy and Immune Responses
- RNA regulation and disease
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
Chiba University
2016-2025
Chiba University Hospital
2025
RIKEN Center for Integrative Medical Sciences
2013-2023
Tokyo Metropolitan Institute of Public Health
2021
RIKEN
2004-2011
Center for Genomic Science
2010
Tokyo University of Science
1999-2001
The University of Tokyo
1999-2001
Osaka University
1998
Kawasaki disease (KD; OMIM 611775) is an acute vasculitis syndrome which predominantly affects small- and medium-sized arteries of infants children. Epidemiological data suggest that host genetics underlie the pathogenesis. Here we report multiple variants in caspase-3 gene (CASP3) are linkage disequilibrium confer susceptibility to KD both Japanese US subjects European ancestry. We found a G A substitution one commonly associated SNP located 5' untranslated region CASP3 (rs72689236; P = 4.2...
There are still no definite treatments for refractory Kawasaki disease (KD). In this pilot study, we evaluated the use of cyclosporin A (CyA) treatment in patients with KD.We prospectively collected clinical data CyA (4-8 mg/kg/d, oral administration) KD using same protocol among several hospitals. Refractory is defined as persistence or recurrence fever (37.5°C more an axillary temperature) at end second intravenous immunoglobulin (2 g/kg) following initial one.Subjects were enrolled out...
Background: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these were mainly performed in Europeans. diverse populations have the potential to advance our understanding of CAD. Methods: We conducted 2 genome-wide for CAD Japanese population, which included 12 494 cases and 28 879 controls 2808 7261 controls, respectively. Then, we transethnic meta-analysis using results replication plus 1000 Genomes with UK Biobank. then explored...
Kawasaki disease (KD; MIM#61175) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD suggest possible involvement the Ca2+/NFAT pathway in pathogenesis KD. ORAI1 Ca2+ release activated (CRAC) channel mediating store-operated entry (SOCE) on plasma membrane. The gene located chromosome 12q24 where positive linkage signal was observed our previous affected sib-pair study A common non-synonymous...
Abstract Background In recent years, there has been considerable research on the use of artificial intelligence to estimate age and disease status from medical images. However, estimation chest X-ray (CXR) images not well studied clinical significance estimated fully determined. Methods To address this, we trained a deep neural network (DNN) model using more than 100,000 CXRs patients’ solely CXRs. We applied our DNN 1562 consecutive hospitalized heart failure patients, 3586 patients...
<h3>Background and aims:</h3> A number of genome-wide association studies have been performed as a robust means identifying susceptibility loci for Crohn's disease (CD). The detected after the completion HapMap project are quite concordant among these studies, suggesting that results reliable. Recently, Wellcome Trust Case Control Consortium (WTCCC) reported primary scanning 17 000 individuals seven diseases, including CD, subsequent study has validated susceptible genetic variants in...
Characteristics of peripheral arterial disease (PAD) are the occlusion or stenosis multiple vessel sites caused mainly by atherosclerosis and chronic lower limb ischemia. To identify PAD susceptible loci, we conducted a genome-wide association study (GWAS) with 785 cases 3,383 controls in Japanese population using 431,666 single nucleotide polymorphisms (SNP). After staged analyses including total 3,164 20,134 controls, identified 3 novel susceptibility loci at IPO5/RAP2A, EDNRA HDAC9 genome...