A5000966277- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Neurological Disease Mechanisms and Treatments
- Vascular Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Glycosylation and Glycoproteins Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Abdominal vascular conditions and treatments
- Inflammatory mediators and NSAID effects
- Erythrocyte Function and Pathophysiology
Shinko Hospital
2013-2023
Département Santé Animale
2023
International Rescue System
2022
Yamanashi Research Institute
2016-2020
Kobe City Medical Center General Hospital
2007-2019
National Kyushu Medical Center
2019
KM Biologics (Japan)
2019
University of Miyazaki
2019
Nippon Medical School
2017
Kawasaki Medical School
2017
We have investigated an oxidoreductive regulatory pathway for the DNA binding activity of a pleiotropic cellular transcription factor, nuclear factor kappa B (NF B), has been by using NF prepared from nucleus and cytosol primary human T lymphocytes. show that reducing catalyst thioredoxin (Trx) plays major role in activation vitro stimulation B-dependent gene expression. demonstrate evidence suggesting redox regulation Trx might be exerted at step after dissociation inhibitory molecule I B,...
Background and Purpose —It has been speculated that the same type of hypertensive small-artery disease can cause either intracerebral hemorrhages or ischemic lesions, depending on circumstances. Methods —To test this hypothesis, we examined association between spontaneous hematomas both small chronic lesions using echo planar T2-weighted MRI. We considered a hypointense area to represent hemorrhage hyperintense an lesion. Results —We identified in 56.7% 30 patients with (mean age, 62.2...
Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due large-vessel occlusion. However, the extent of ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit efficacy EVT.To compare and safety EVT according ASPECTS 3 or less vs 4 5.The Recovery by Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted...
OBJECTIVE The presence of disproportionately enlarged subarachnoid space hydrocephalus (DESH) on brain imaging is a recognized finding idiopathic normal pressure (iNPH), but the features DESH can vary across patients. aim this study was to evaluate utility MRI-based scoring for predicting prognosis after surgery. METHODS In single-center, retrospective cohort study, score determined by consensus between group neurosurgeons, neurologists, and neuroradiologist based preoperative MRI findings...
Background and Purpose— We investigated whether administration of edaravone, a free radical scavenger, before or during tissue-type plasminogen activator (tPA) can enhance early recanalization in major arterial occlusion. Methods— The YAMATO study (Tissue-Type Plasminogen Activator Edaravone Combination Therapy) is an investigator-initiated, multicenter (17 hospitals Japan), prospective, randomized, open-label study. Patients with stroke secondary to occlusion the M1 M2 portion middle...
Background The aim of the present study was to investigate efficacy and safety antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48 hours symptom onset. Methods Results ADS (Acute Aspirin Plus Cilostazol Dual Therapy Non‐Cardiogenic Stroke Patients Within Hours Symptom Onset ) is an investigator‐initiated, prospective, multicenter (34 hospitals in Japan), randomized, open‐label, aspirin‐controlled trial. Acute onset were studied. subjects...
Abstract —Accumulation of substantial numbers activated T lymphocytes, as well monocyte/macrophages, in focal areas arterial intima appears to be a hallmark atherogenesis. Our previous report demonstrated that lysophosphatidylcholine (lyso-PC), polar phospholipid component is increased atherogenic lipoproteins and atherosclerotic lesions, can upregulate the expression heparin-binding epidermal growth factor–like factor interleukin (IL)-2 receptor cultured human peripheral lymphocytes. In...
The Merci retrieval system is a useful modality for the recanalization of acute cerebral artery occlusion. However, it remains unclear whether tortuosity middle (MCA) plays role in successful recanalization. In this study, we investigated association between shape horizontal MCA segment (M1) and using with or without adjunctive treatments. Twenty-three patients M1 occlusion underwent thrombectomy treatments July 2010 2012. anteroposterior view final angiograms was used to measure curve...
Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal (PPT) with an prognosis between pineocytoma (PC) and pineoblastoma (PB). It considered intermediate-grade divided into grade II or III.The number available reports about presently limited, the appropriate management for this has not yet been determined.The authors report rare case PC 63-year-old woman who presented lower-extremity weakness gait disturbance. A mass...
Although considerable efforts have been made to develop diagnostic tools for predicting the outcome of oral food challenges, tests outgrowth allergies are lacking.The aim this study was assess value wheal size and skin index (SI) (the ratio an allergen-induced a histamine-induced diameter) skin-prick test based on controlled provocation cow's milk. Moreover, we assessed whether and/or SI were useful milk allergy (CMA).This included 135 children with suspected CMA. Eighty-one patients...
Abstract —Lysophosphatidylcholine (lyso-PC), a polar phospholipid that is increased in atherogenic lipoproteins and atherosclerotic lesions, has been shown to transcriptionally induce the expression of endothelial genes relevant atherogenesis. In cultured bovine aortic cells (BAECs), we show lyso-PC induces early growth response factor (Egr)-1 thereby activates proximal promoter platelet-derived (PDGF)-A chain located 55 71 bp upstream from transcription start site, which be crucial for...
A 62-year-old man with neurofibromatosis type 1 presented rapid growth of a scalp mass. Head computed tomography demonstrated large extracranial tumor soft tissue density massive intratumoral hematoma. Cerebral angiography remarkable hypervascularity the tumor. Preoperative embolization and total removal was performed. The contained amount hematoma (500 ml). histological diagnosis neurofibroma without malignant transformation. Benign showing hemorrhage is rare. Rapid or in may be an indicator
<b><i>Background and Purpose:</i></b> Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term are not well known. We hypothesized successful might be associated with improvement beyond therapy. To assess days, we analyzed association of a temporal change in modified Rankin Scale (mRS) score from to 1 year <b><i>Methods:</i></b>...
An increase in Lewis- and core-type fucosylation of haptoglobin has been reported patients with pancreatic cancer (PC), suggesting that fucosylated is a candidate PC biomarker. Previously, we developed Pholiota squarrosa lectin antibody enzyme-linked immunosorbent assay (PhoSL-ELISA) system for the detection core-fucosylated haptoglobin. However, this methodology, positive results were only obtained some PC, demonstrating need more sensitive system. In current study, an improved PhoSL-ELISA...
Lysophosphatidylcholine (lyso‐PC), a polar phospholipid increased in atherogenic lipoproteins and atherosclerotic lesions, has been shown to induce transcription of variety endothelial genes relevant atherogenesis. Lyso‐PC activate c‐jun N‐terminal kinase (JNK) activator protein 1 (AP‐1) thereby stimulate the gene. Here we provide evidence that lyso‐PC can phosphorylate cyclic AMP responsive element binding (CREB) jun2 12‐ O ‐tetradecanoylphorbol 13‐acetate response (jun2TRE) site promoter,...