A5005325316- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Mercury impact and mitigation studies
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Carcinogens and Genotoxicity Assessment
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- T-cell and Retrovirus Studies
- Cardiovascular Health and Disease Prevention
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Vascular Malformations Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Marine animal studies overview
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Heavy metals in environment
- Analytical Chemistry and Chromatography
- Peripheral Artery Disease Management
- Total Knee Arthroplasty Outcomes
- Spinal Fractures and Fixation Techniques
National Institute for Minamata Disease
1995-2024
Hakodate National Hospital
2005-2024
Kagoshima Medical Center
2015-2024
National Hospital Organization
2015-2023
International Rescue System
2022
Sapporo Medical University
1996-2021
Kurume University Hospital
2021
Kawasaki Medical School Hospital
2021
Toranomon Hospital
2021
Ise Red Cross Hospital
2021
Importance Cell therapy is a promising treatment approach for stroke and other diseases. However, it unknown whether MultiStem (HLCM051), bone marrow–derived, allogeneic, multipotent adult progenitor cell product, has the potential to treat ischemic stroke. Objective To assess efficacy safety of when administered within 18 36 hours onset. Design, Setting, Participants The Treatment Evaluation Acute Stroke Using Regenerative Cells (TREASURE) multicenter, double-blind, parallel-group,...
Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due large-vessel occlusion. However, the extent of ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit efficacy EVT.To compare and safety EVT according ASPECTS 3 or less vs 4 5.The Recovery by Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted...
Background Endovascular therapy has been shown to be effective in patients with acute cerebral large‐vessel occlusion, but real‐world efficacies are unknown. Methods and Results We conducted a prospective registry at 46 centers between October 2014 January 2017. Eligible were those who aged 20 years or older, hospitalized within 24 hours of the onset. enrolled both consecutive treated without endovascular therapy. included thrombectomy, balloon angioplasty, stenting, local fibrinolysis,...
Polychlorinated biphenyl (PCB) poisonings occurred in western Japan, where it is called yusho, 1968, and central Taiwan, yu-cheng, 1979. The average concentrations of PCBs the adipose tissue, liver blood yusho patients yu-cheng were 1.9 ppm, 0.08 6.7 ppb 99 ppb, respectively. Seven PCB congeners, such as 2,4,5,3',4'-pentachloro-, 2,3,4,3',4'-pentachloro-, 2,4,5,2',4',5'-hexachloro-, 2,3,4,2',4',5'-hexachloro-, 2,3,4,5,3',4'-hexachloro-, 2,3,4,5,2',4',5'-heptachloro-...
Endovascular therapy (EVT) is strongly recommended for acute cerebral large vessel occlusion with the Alberta Stroke Program Early CT Score (ASPECTS) ≥6 due to of internal carotid artery or M1 segment middle artery. However, effect EVT patients who have ischemic core ASPECTS ≤5 (0–5) was not established. The purpose this study elucidate outcomes core.Based on data Recovery by Salvage Cerebral Ultra-Acute Embolism Japan Registry 2, and pretreatment 0 5 noncontrast diffusion-weighted image...
We surveyed the total mercury (T-Hg) and methyl (M-Hg) levels in red meat products (n = 160) from small cetacean species sold for human consumption markets throughout Japan 2000 to 2003. Genetic identification showed that originated nine species: false killer whale, bottlenose dolphin, short-finned pilot striped rough-toothed Risso's pantropical spotted Baird's beaked Dall's porpoise. T-Hg M-Hg concentrations all exceeded provisional permitted of (0.4 μg/wet g) (0.3 fish shellfish set by...
Abstract Human T cell lymphotropic virus type 1 (HTLV-1)-specific CTL are thought to be immune effectors that reduce the risk of adult leukemia (ATL). However, in vivo conditions anti-HTLV-1 before and after ATL development have yet determined. To characterize asymptomatic HTLV-1 carriers (AC) patients, we analyzed frequency diversity HTLV-1-specific CD8+ cells PBMC 35 AC 32 patients using 16 distinct epitopes Tax or Env/HLA tetramers along with intracellular cytolytic effector molecules...
Polychlorinated biphenyl (PCB) poisonings occurred in western Japan, where it is called Yusho, 1968, and central Taiwan, Yu-Cheng, 1979.The average concentrations of PCBs the adipose tissue, liver blood Yusho patients Yu-Cheng were 1.9 ppm, 0.08 6.7 ppb 99 ppb, respectively.Seven PCB congeners, such as 2,4,5,3 ',4'-pentachloro-, 2,3,4,3',4'- pentachloro-, 2,4,5,2',4',5'-hexachloro-, 2,3,4,2',4',5'-hexachloro-, 2,3,4,5,3',4'-hexachloro-, 2,3,4,5,2',4',5'- heptachloro-and...
Background The safety and effectiveness of stent retriever use for patients with acute large vessel occlusion (LVO) due to intracranial atherosclerotic disease (ICAD) is not well established. We investigated the differences in clinical outcomes without ICAD. Methods analyzed Japan Trevo Registry, a nationwide registry which enrolled LVO who underwent endovascular therapy (EVT) using alone or combination an aspiration catheter. compared technical EVT between ICAD No-ICAD groups. primary...
Differences in pathology were found between acute and chronic exposure to methylmercury, mercury vapor, inorganic mercury. Characteristic pathologic changes produced by organic the brain have previously been described patients with Minamata disease. The brains of who presented onset symptoms died within 2-mo showed loss neurons reactive proliferation glial cells, microcavitation, vascular congestion, petechial hemorrhage, edema cerebral cortices, predominantly calcarine, pre- postcentral,...
Paroxetine discontinuation symptoms can at times be severe enough to reduce the quality of life. However, it is currently not possible predict occurrence syndrome before initiation or paroxetine treatment. In this study, we investigated effects genetic polymorphisms in serotonin 1A, 2A, 2C, 3A, and 3B receptor, transporter, cytochrome P450 2D6 (CYP2D6) genes on syndrome. A consecutive series 56 Japanese patients who had a diagnosis major depressive anxiety disorder according Diagnostic...
We determined methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) in human adipose, liver, brain, lung tissues obtained from 11 Belgian individuals (9-62 years age). The total concentration MeSO2-CBs (lipid weight basis) decreased the following order: liver (mean, 9.30 ng/g; range, 1.68-27.03 ng/g lipid) > [mean, 2.72 not detected (ND) to 11.54 lipid] adipose tissue 1.57 0.33-4.33 brain 0.24 ND-0.56 lipid). profiles...
Abstract Previous studies have suggested that higher anti‐human T‐lymphotropic virus 1 (HTLV‐1) antibody titer and lower anti‐HTLV‐1 Tax reactivity are risk factors for adult T‐cell leukemia/lymphoma. In the present study, we analyzed relationships between these clarified their significance. Forty‐five carriers were examined anti‐Tax by ELISA. addition, 43 of 45 with HLA‐A*0201 and/or A*2402 frequency Tax‐specific cytotoxic T lymphocytes (CTLs) using HTLV‐1/HLA tetramers, 44 proviral load...
Background and Purpose— The treatment prognosis of acute large vessel occlusion with mild symptoms have not been sufficiently studied. present study aimed to investigate the clinical or radiological predictors outcome in patients stroke due occlusion. Methods— Of 2420 RESCUE-Japan Registry 2 (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism-Japan 2), a multicenter prospective registry Japan, modified Rankin Scale scores 0 before onset initial National Institutes Health...
Background The optimal duration of dual antiplatelet therapy (DAPT) after stent-assisted coil embolization (SACE) for cerebral aneurysm remains uncertain. This randomized trial short- versus long-term Dual AntiPlatelet Therapy Stent-Assisted treatment CErebral (DAPTS ACE) aimed to clarify whether DAPT can reduce the occurrence ischemic stroke in patients with aneurysms treated by SACE compared short-term DAPT. Methods Patients were enrolled from 17 hospitals Japan. within 30 days and...
Cetacean products sold for human consumption in Japan originate from a wide range of whale, dolphin, and porpoise species caught off several areas the coast, Antarctic North Pacific Oceans. We surveyed total mercury (T-Hg) levels red meat, most popular cetacean Japan. also analyzed DNA these to obtain information regarding species. According genetic analysis, meats originating nine odontocete six mystecete were Japanese markets. T-Hg concentrations all (0.52−81.0 μg/wet g, n = 137) exceeded...