A5064691879- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Vestibular and auditory disorders
- Spinal Cord Injury Research
- Venous Thromboembolism Diagnosis and Management
- Spinal Fractures and Fixation Techniques
- Neurogenesis and neuroplasticity mechanisms
- Stroke Rehabilitation and Recovery
- Neuroblastoma Research and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nerve injury and regeneration
- Barrier Structure and Function Studies
- Mesenchymal stem cell research
- Trauma Management and Diagnosis
- Brain Metastases and Treatment
Hirosaki University
2015-2025
Hirosaki National Hospital
2023-2024
Hirosaki University Hospital
2017-2022
International Rescue System
2022
Loma Linda University
2006
Importance Cell therapy is a promising treatment approach for stroke and other diseases. However, it unknown whether MultiStem (HLCM051), bone marrow–derived, allogeneic, multipotent adult progenitor cell product, has the potential to treat ischemic stroke. Objective To assess efficacy safety of when administered within 18 36 hours onset. Design, Setting, Participants The Treatment Evaluation Acute Stroke Using Regenerative Cells (TREASURE) multicenter, double-blind, parallel-group,...
Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due large-vessel occlusion. However, the extent of ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit efficacy EVT.To compare and safety EVT according ASPECTS 3 or less vs 4 5.The Recovery by Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted...
<b><i>Background:</i></b> Several clinical studies have indicated the efficacy of cilostazol, a selective inhibitor phosphodiesterase 3, in preventing cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). They were not double-blinded trial resulting disunited results on assessment end points among studies. The randomized, double-blind, placebo-controlled study was performed to assess effectiveness cilostazol vasospasm....
OBJECTIVE It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) induced by free radicals released from a clot. This study therefore investigated the effect of new radical scavenger, edaravone, in treatment patients with SAH. METHODS Ninety-one SAH participated this and were randomized into control group (n = 42) an edaravone-treated 49). The difference between 2 groups terms incidence delayed ischemic neurological deficits (DINDs) infarction caused...
Background and Purpose— Recent studies have shown that selective inhibition of specific subsets intercellular adhesion molecules protects the brain during ischemia. We studied integrin αvβ3 with cyclo [Arg-Gly-Asp- d -Phe-Val] (cRGDfV) in rat middle cerebral artery occlusion model (MCAO). Methods— Rats were treated before after MCAO cRGDfV. Physiological parameters, expression αvβ3, infarction volume, water content, Evans Blue exudation, IgG histology, immunohistochemistry, western blotting...
Statins have pleiotropic effects that are considered beneficial in preventing cerebral vasospasm and delayed ischemia after aneurysmal subarachnoid hemorrhage (aSAH). Many studies using statins been performed but failed to show remarkable effects. We hypothesized a long-acting statin would be more effective, due longer half-life stronger Patients with aSAH were randomly assigned pitavastatin group (4 mg daily; n = 54) placebo ( repair of ruptured aneurysm. The primary efficacy end point was...
The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). aims this study were to investigate whether combination treatment, with pitavastatin as an inhibitor RhoA and fasudil Rho-kinase, prevents vasospasm. SAH was simulated using double-hemorrhage rabbit model, pitavastatin, or fasudil, both (combination treatment) administrated. basilar artery (BA)...
The relatively high rate of post-operative recurrence in the treatment chronic subdural hematoma (CSDH) is a significant problem. Goreisan an herbal medicine that exhibits hydragogue effect by inhibiting expression aquaporins, and its efficacy preventing CSDH has been suggested several case trials. This multi-center prospective randomized controlled trial was performed to investigate preventative goreisan on recurrence. Patients with symptomatic over 60 years old undergoing burr hole surgery...
OBJECTIVE Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality rates. In particular, functional outcomes of SAH caused by large or giant (≥ 10 mm) ruptured intracranial aneurysms are worsened procedure-related complication However, studies describing the risk factors for poor specific to large/giant sparse. addition, recurrence rebleeding rates following treatment such remain a concern. This study aimed clarify short-term long-term durability due using...
Calpains and cathepsins are two families of proteases that play an important role in ischemic cell death. In this study, we investigated the effect E64d, a mu-calpain cathepsin B inhibitor, prevention neuronal endothelial apoptotic death after focal cerebral ischemia rats. Rats underwent 2 hr transient from middle artery occlusion (MCAO) were sacrificed 24 later. E64d (5 mg/ kg intraperitoneally) was administered 30 min before MCAO. Assessment included neurological function, infarction...
Abstract Ischemic stroke is a major cause of morbidity and mortality in industrialized nations. We tested the effect postischemic treatment cyclo‐RGDfV (cRGDfV), selective inhibitor integrin αvβ3, middle cerebral artery occlusion (MCAO) model ischemic rats. Rats were randomly divided into three groups: sham operation (n = 13), MCAO with no 18), cRGDfV 28). Focal ischemia was induced suture method for 2 hr, given 1 hr after reperfusion (3 ischemia). All animals sacrificed 24 reperfusion....