A5011530088- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Hip disorders and treatments
- Pelvic and Acetabular Injuries
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopedic Surgery and Rehabilitation
- Nerve injury and regeneration
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Medical Imaging and Analysis
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Anesthesia and Pain Management
- Peripheral Nerve Disorders
- Sarcoma Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Nerve Injury and Rehabilitation
Chiba University Hospital
2008-2025
Chiba University
2016-2025
Research Organization of Information and Systems
2024-2025
Funabashi Orthopaedic Hospital
2025
The University of Tokyo
2024
Toho University
2021-2024
Toho University Medical Center Sakura Hospital
2021-2024
St. Marianna University School of Medicine
2019-2023
Kitasato University
2011-2023
Seirei Sakura Citizen Hospital
2023
Prospective study.To examine the efficacy of teriparatide or bisphosphonate treatment to reduce pedicle screw (PS) loosening after instrumented lumbar posterolateral fusion in postmenopausal women with osteoporosis.Failure fixation caused by PSs osteoporosis is a problem spinal surgery. Oral administration intermittent injection parathyroid hormone increases bone mass and reduces risk osteoporotic vertebral fractures. Although these treatments may be factor improving quality, clinical study...
A retrospective multicenter survey.To investigate the perioperative complications of oblique lateral interbody fusion (OLIF) surgery.OLIF has been widely performed to achieve minimally invasive, rigid lumbar fusion. The associated are not yet well described.The participants were patients who underwent OLIF surgery under diagnosis degenerative diseases between April 2013 and May 2015 at 11 affiliated medical institutions. collected data classified into intraoperative early-stage postoperative...
In Brief Objectives. The purpose of the current study was to evaluate changes in tumor necrosis factor-α (TNF-α) and TNF-α receptor 1 (p55 receptor) using double fluorescent immunohistochemistry glial neural cells dorsal root ganglion spinal cord after sciatic nerve injury mice. Summary Background Data. is a primary mediator inflammatory response primarily synthesized released nervous system by macrophages Schwann following peripheral injury. also from astrocytes microglia central system,...
Immunohistochemistry for tumor necrosis factor (TNF) and protein gene product (PGP) 9.5 in vertebral endplates of patients with discogenic low back pain Modic Type 1 or 2 endplate changes on MRI.To examine whether inflammatory cytokines nerve in-growth into the are associated pain.Degenerated discs abnormalities can be a cause pain. However, presence TNF-immunoreactive cells PGP 9.5-immunoreactive fibers has not been studied MRI.Eighteen showing either normal intensity signals MRI (endplate...
The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear, whereas mixed evidence inflammatory and neuropathic has been noted. We aimed to investigate pain-related sensory innervation in a monoiodoacetate (MIA)-induced model OA.Sixty seventy female Sprague Dawley rats six week-old underwent intra-articular MIA fluorogold (FG) retrograde neurotracer injection into their right (ipsilateral) knee, while left knees were treated with FG saline as control (contralateral knee)....
In Brief Study Design. Prospective trial. Objective. To examine the clinical efficacy of teriparatide for bone union after instrumented lumbar posterolateral fusion using local grafting in women with postmenopausal osteoporosis. Summary Background Data. Intermittent parathyroid hormone (PTH) treatment increases mass and reduces risk osteoporotic vertebral fractures. Recombinant human PTH (1–34) has already been approved as a severe Preclinical data support spinal fusion. However, results...
One of the sources knee pain in osteoarthritis (OA) is believed to be related local chronic inflammation joints, which involves production inflammatory cytokines such as tumor necrosis factor alpha (TNFα), interleukin (IL)-6, and nerve growth (NGF) synovial membrane, these are promote pathological OA. In present study, correlations between proinflammatory fluid radiographic changes functional scores among OA patients were examined. Synovial was harvested from knees 47 consecutive patients,...
Surgery for lumbar spinal degeneration disease is widely performed. While posterior decompression and fusion are popular, anterior interbody (ALIF) also used treatment. Extreme lateral (XLIF) commonly noninvasive ALIF; however, several complications, such as nerve psoas muscle injury, have been reported. In the current study, we examined clinical efficacy complications of oblique (OLIF) disease.Thirty-five patients with degenerated spondylolisthesis, discogenic pain, kyphoscoliosis were...
Pain from osteoarthritis (OA) is generally classified as nociceptive (inflammatory). Animal models of knee OA have shown that sensory nerve fibers innervating the are significantly damaged with destruction subchondral bone junction, and induce neuropathic pain (NP). Our objective was to examine NP in knees patients using painDETECT (an questionnaire) evaluate relationship between NP, intensity, stage OA.Ninety-two were evaluated this study. scores Visual Analogue Scales (VAS), Western...
The purpose of this study was to clarify the incidence (CS)-associated osteonecrosis among different underlying diseases and evaluate risk factors for steroid-associated in a prospective MRI study.We prospectively used 337 eligible disease patients requiring CS therapy succeeded examining 1199 joints (hips knees) 302 with at least 1 year starting immediately after onset (1-year follow-up rate 90%). included SLE 687 (173 patients) variety other rheumatological disorders 512 (129 patients).The...
The importance of pelvic incidence-lumbar lordosis (PI-LL: PI minus LL) mismatch is emphasized in long-segment fusion for adult spinal deformity; however, there are few studies evaluating the influence PI-LL on surgical outcomes after short-segment fusion. In this study, we have examined effects lumbar intervertebral degenerative diseases. Patients with disease treated by (1 or 2 levels) transforaminal interbody were divided into Group A (PI-LL ≤ 10°: n = 22) and B ≥ 11°: 30). Pre-and...
Prospective case series.To examine the clinical efficacy of mini-open anterior retroperitoneal lumbar interbody fusion: oblique lateral fusion (OLIF) for degenerated spinal kyphoscoliosis.The existing surgical procedures treatment kyphotic deformity, including Smith-Petersen osteotomy, pedicle subtraction and vertebral column resection procedures, are invasive in nature. Extreme to provide less deformity has been reported, but complications nerve psoas muscle injury have noted. In current...
In Brief Study Design. Immunohistochemical and behavioral study using the SPARC (secreted protein, acidic, rich in cysteine)-null mouse model of low back pain (LBP) associated with accelerated intervertebral disc (IVD) degeneration. Objective. To determine if signs LBP SPARC-null mice are accompanied by sensory nervous system plasticity. Summary Background Data. IVD pathology is a significant contributor to chronic LBP. humans rodents, decreased expression We previously reported that exhibit...
Study Design. The vertebral levels of dorsal root ganglia innervating the portion L5–L6 intervertebral disc were investigated in rats using a retrograde transport method. pathways and functions nerve fibers supplying determined by denervation immunohistochemistry. Objectives. lumbar has been reported to be innervated segmentally, but anesthetic block paravertebral sympathetic trunks L2 spinal can relieve discogenic low back pain. In current study, sensory innervation was investigated,...
Because the authors encountered 4 cases of hardware migration following transforaminal lumbar interbody fusion, a retrospective study was conducted to identify factors influencing posterior fusion cages.Patients with degenerative disc disease (125 individuals; 144 levels) were treated using and followed for 12-33 months. Medical records pre- postoperative radiographs reviewed, incidence cage analyzed.Postoperative found in patients at or before 3 all cages that migrated postoperatively...
Randomized, controlled study.To evaluate the diagnosis of discogenic low back pain (LBP) with discography and discoblock.Discogenic LBP is usually diagnosed by magnetic resonance imaging discography. However, reliability controversial. Previously, we reported usefulness discoblock bupivacaine for diagnosis, improved results anterior interbody fusion surgery. that study was not a randomized, study. Therefore, purpose current to compare surgery after discoblock.Patients (n = 42) severe showing...