A5091328672- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Lower Extremity Biomechanics and Pathologies
- Clostridium difficile and Clostridium perfringens research
- Welding Techniques and Residual Stresses
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Fusion materials and technologies
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
- Antimicrobial Resistance in Staphylococcus
- Advanced Welding Techniques Analysis
- Spine and Intervertebral Disc Pathology
- Parkinson's Disease Mechanisms and Treatments
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Musculoskeletal Disorders and Rehabilitation
- Medical and Biological Sciences
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
- Bone and Joint Diseases
Kyoto University
2016-2025
Kumamoto University
2024
Kyoto University Hospital
2016-2024
Toshiba (Japan)
2011-2022
Taisho Pharmaceutical (Japan)
2017
Chugai Pharma (United States)
2017
Astellas Pharma (Japan)
2017
AbbVie (Japan)
2017
Fukuyama City Hospital
2017
Kyoto City Hospital
2016
The norA gene cloned from chromosomal DNA of quinolone-resistant Staphylococcus aureus TK2566 conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin, but only low or no at all hydrophobic ones nalidixic acid, oxolinic sparfloxacin in S. Escherichia coli. 2.7-kb fragment containing the had a long open reading frame coding for 388 amino acid residues with molecular weight 42,265, which was consistent experimental value about...
Study Design The authors studied the origin of nerves supplying posterior portion lumbar intervertebral discs in rats by resection sympathetic trunks. Objective To understand discogenic low back pain from innervation discs. Summary Background Data afferent pathways have not been thoroughly. It has reported that stimulation an inflamed lower spinal nerve root elicits leg but and evokes only pain. These facts suggest sensation is transmitted via roots. Methods Forty-five Wistar were used....
The effect of recombinant human interleukin-1a on the survival rate Std-ddY male mice systemically infected with Pseudomonas aeruginosa 12 or Klebsiella pneumoniae P-5709 was evaluated. In P. infection, given intramuscularly twice, 3 days and 1 day before inoculation bacteria, most effectively protected animals from death due to infection. dose dependent, a maximum 92.5% at 10 micrograms per mouse, while only 8.3% control group survived until end observation period. 50% effective 0.261...
AT-4140, 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3,5- dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, showed broad and potent antibacterial activity. Its MICs for 90% of the strains tested were 0.1 to 0.78 micrograms/ml against gram-positive organisms, such as members genera Staphylococcus, Streptococcus, Enterococcus, 0.0125 1.56 gram-negative family Enterobacteriaceae Pseudomonas, Branhamella, Campylobacter, Haemophilus, Neisseria. 0.025 glucose nonfermenters,...
Randomized, controlled study.To evaluate the diagnosis of discogenic low back pain (LBP) with discography and discoblock.Discogenic LBP is usually diagnosed by magnetic resonance imaging discography. However, reliability controversial. Previously, we reported usefulness discoblock bupivacaine for diagnosis, improved results anterior interbody fusion surgery. that study was not a randomized, study. Therefore, purpose current to compare surgery after discoblock.Patients (n = 42) severe showing...
Objectives Little biomechanical information is available about kinematically aligned (KA) total knee arthroplasty (TKA). The purpose of this study was to simulate the kinematics and kinetics after KA TKA mechanically (MA) with four different limb alignments. Materials Methods Bone models were constructed from one volunteer (normal) three patients deformities (slight, moderate severe varus). A dynamic musculoskeletal modelling system used analyse tibiofemoral contact force. stress on tibial...
Unicompartmental knee arthroplasty (UKA) is one surgical option for treating symptomatic medial osteoarthritis. Clinical studies have shown the functional benefits of UKA; however, optimal alignment tibial component still debated. The purpose this study was to evaluate effects coronal and sagittal plane in UKA on kinematics cruciate ligament tension, using a musculoskeletal computer simulation.The first aligned perpendicular mechanical axis tibia, with 7° posterior slope (basic model)....
A 4.2-kb DNA fragment conferring quinolone resistance was cloned from a quinolone-resistant clinical isolate of Staphylococcus aureus and shown to possess part the grlB gene mutated grlA gene. S-80-->F E-84-->K mutations in product were responsible for resistance. The genes dominant over wild-type allele, irrespective dosage transformation experiment with alone. However, dominance by depended on when bacteria transformed combination. Quinolone-resistant gyrA mutants easily isolated...
This article aimed to comprehensively introduce clinical scoring of pathological conditions the knee. Review articles on scores knee joints were searched. The frequency used in said are presented as whole-knee or according specific diseases. Frequently systems separately explained terms validity and clinically important values. Of 132 review articles, 95 included this review. Among these 95, top five frequently Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury...
We recently reported the β‐lactamase production and antimicrobial susceptibility of anaerobic gram‐negative rods isolated from pus specimens 93 orofacial odontogenic infections. In this report, we determine bacteriology bacteria other than rods, mainly gram‐positive cocci, same specimens. Streptococcus constellatus Peptostreptococcus micros were frequent isolates all types infection examined. prevotii , Corynebacterium species, Eubacterium species recovered only dentoalveolar infections,...
Water-insoluble fragmin/protamine microparticles of about 0.5-1 mum in diameter were prepared by simple mixing low-molecular-weight heparin (fragmin) with protamine. We investigated the capability these to immobilize fibroblast growth factor (FGF)-2, protect FGF-2 against degradation, enhance activity, and facilitate controlled release FGF-2. bound high affinity (Kd = 2.08 x 10(-9) M) half-life FGF-2-activity was prolonged substantially through binding microparticles, protection from...
Neurotoxigenic Clostridium butyricum was isolated from the food implicated in an outbreak of clinically diagnosed type E botulism China. PCR assay showed that isolate (LCL 155) contained botulinum toxin gene. This appears to be first report neurotoxigenic C. causing food-borne botulism.