Tsutomu Akazawa

ORCID: 0000-0003-2348-0994
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About
Contact & Profiles
Research Areas
  • Scoliosis diagnosis and treatment
  • Spine and Intervertebral Disc Pathology
  • Spinal Fractures and Fixation Techniques
  • Musculoskeletal pain and rehabilitation
  • Pelvic and Acetabular Injuries
  • Medical Imaging and Analysis
  • Bone health and osteoporosis research
  • Aortic Disease and Treatment Approaches
  • Hip disorders and treatments
  • Cervical and Thoracic Myelopathy
  • Orthopaedic implants and arthroplasty
  • Nutrition and Health in Aging
  • Anesthesia and Pain Management
  • Bone and Joint Diseases
  • Connective tissue disorders research
  • Pain Mechanisms and Treatments
  • Abdominal vascular conditions and treatments
  • Cardiac, Anesthesia and Surgical Outcomes
  • Infectious Diseases and Tuberculosis
  • Total Knee Arthroplasty Outcomes
  • Orthopedic Infections and Treatments
  • Spinal Hematomas and Complications
  • Body Composition Measurement Techniques
  • Spinal Dysraphism and Malformations
  • Peripheral Nerve Disorders

St. Marianna University School of Medicine
2017-2025

Seirei Sakura Citizen Hospital
2015-2024

Japanese Red Cross Narita Hospital
2023

Kitasato University
2020-2023

Toho University Medical Center Sakura Hospital
2023

Toho University
2023

Asahi General Hospital
2023

Chiba University Hospital
2023

Chiba University
2004-2023

Yokohama City Seibu Hospital
2023

A retrospective multicenter survey.To investigate the perioperative complications of oblique lateral interbody fusion (OLIF) surgery.OLIF has been widely performed to achieve minimally invasive, rigid lumbar fusion. The associated are not yet well described.The participants were patients who underwent OLIF surgery under diagnosis degenerative diseases between April 2013 and May 2015 at 11 affiliated medical institutions. collected data classified into intraoperative early-stage postoperative...

10.1097/brs.0000000000001650 article EN Spine 2016-04-26

A retrospective, multicenter study.To investigate the occurrence of and factors related to postoperative adding-on in Lenke type 1A curve.Although several studies have investigated associated with curve, these not been elucidated a large study population.This included 112 patients who were followed more than 2 years after undergoing selective posterior thoracic fusion surgery for Type curve (8 males, 104 females; mean age at surgery, 16.1 yr; follow-up, 3.6 yr). The lower instrumented...

10.1097/brs.0b013e318279b666 article EN Spine 2012-10-26

Objective: In recent years, there has been an increase in research on the therapeutic effects of exergaming, but have few studies these types interventions for chronic low back pain. this study, we hypothesized that Nintendo Ring Fit Adventure (RFA) exergame would be effective patients with pain, and conducted a randomized prospective longitudinal study. Materials Methods: Patients pain were included Twenty randomly selected (9 males 11 females, mean age 49.3 years) RFA group, exergaming was...

10.1089/g4h.2020.0180 article EN Games for Health Journal 2021-04-23

The motions of chest wall and diaphragm were measured in patients with scoliosis healthy individuals using dynamic breathing magnetic resonance imaging.To investigate the during deep idiopathic scoliosis.Despite central role respiratory maintaining ventilation, it is difficult to measure describe because limited methods available. kinematics respiration have not yet been clarified.Dynamic fast spoiled gradient-recalled echo sequences used for 18 9 individuals. evaluated a cineloop view...

10.1097/01.brs.0000106490.82936.89 article EN Spine 2004-01-29

Retrospective study.We compared the accuracy of O-arm-based navigation with computed tomography (CT)-based in scoliotic surgery.No previous reports comparing results conventional CT-based surgery have been published.A total 222 pedicle screws were implanted 29 patients using (group C) and 416 32 O). Postoperative CT was performed to assess screw accuracy, established Neo classification (grade 0: no perforation, grade 1: perforation <2 mm, 2: ≥2 <4, 3: ≥4 mm).In group C, 188 (84.7%)...

10.4184/asj.2014.8.3.331 article EN cc-by-nc Asian Spine Journal 2014-01-01

A case control study.To determine the clinical outcome of middle-aged patients surgically treated for adolescent idiopathic scoliosis and to compare their outcomes with assessments age- sex-matched healthy controls.Several long-term follow-up studies have been published on surgical treatment in who reached 20s or 30s. However, middle age remain unknown.This study included 256 (AIS) between 1968 1988. The Scoliosis Research Society Patient Questionnaire (SRS-22) Roland-Morris Disability (RDQ)...

10.1097/brs.0b013e31823d2b06 article EN Spine 2011-10-28

In Brief Study Design. Using a retrograde tracing method and immunohistochemistry, we assessed the expression of activating transcription factor 3 (ATF3), marker nerve injury, growth-associated protein 43 (GAP-43), axonal growth, in dorsal root ganglion (DRG) neurons innervating lumbar intervertebral discs rats. Objectives. To investigate ATF3 GAP-43 DRGs after exposure nucleus pulposus to outside anulus fibrosus. Summary Background Data. Degeneration is considered as cause low back pain. We...

10.1097/01.brs.0000219946.25103.db article EN Spine 2006-06-01

The purpose of this study was to investigate the occurrence and factors associated with postoperative shoulder imbalance (PSI) in Lenke type 1A curve. This included 106 patients Type curve who were followed up more than two years after posterior correction surgery. Pedicle screw (PS) constructs used 84 patients, hybrid 22. upper instrumented vertebra rostral upper-end (UEV) 70 at UEV 26, below 10. clavicle angle T1 tilt measured as PSI indicators, correlations between radiographic parameters...

10.1186/1471-2474-15-366 article EN cc-by BMC Musculoskeletal Disorders 2014-11-05

Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them locus on chromosome 6q24.1 that we by GWAS in Japanese cohort. The represented rs6570507 located within GPR126. To ensure AIS, conducted meta-analysis using eight cohorts from East Asia, Northern Europe USA. analysis included total 6,873 cases 38,916 controls...

10.1038/s41598-018-29011-7 article EN cc-by Scientific Reports 2018-07-26

Study Design: Retrospective cohort study. Objective: To develop a machine learning (ML) model that predicts the progression of AIS using minimal radiographs and simple questionnaires during first visit. Summary Background Data: Several factors are associated with angle in patients AIS. However, it is challenging to predict angular at Methods: Among female treated single institution from July 2011 February 2023, 1119 cases were studied. Patient data, including demographic radiographic data...

10.1097/brs.0000000000004986 article EN Spine 2024-03-13

Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis AIS depend on curve progression, identifying factors related to progression important in its management. Although several genetic loci for occurrence are reported, no locus has been identified. To identify genes associated with we conducted genome-wide association study followed by replication using total 2,543 subjects who were evaluated the progression. We...

10.1093/hmg/ddx291 article EN Human Molecular Genetics 2017-07-20

Study Design Cross-sectional observational study. Purpose To compare measurements of appendicular skeletal muscle mass (ASMM) and whole fat (WFM) obtained using dualenergy X-ray absorptiometry (DXA) bioelectrical impedance analysis (BIA) among patients with low back pain (LBP). Moreover, the study investigated correlation between BIA-based ASMM DXA-based bone mineral density (BMD). Overview Literature If reliable, BIA may be a useful alternative to DXA as screening tool for sarcopenia...

10.31616/asj.2018.12.5.839 article EN cc-by-nc Asian Spine Journal 2018-09-11

The aim of this study was to determine whether advanced glycation end products (AGEs) revealed by skin autofluorescence (SAF), serum and urine pentosidine level, homocysteine level can serve as a biomarker for sarcopenia in older women. participants were 70 elderly AGEs pentosidine, homocysteine, SAF measured aging markers. This shows that among the biomarkers aging, correlates with loss appendicular lean mass sarcopenia. Moreover, values exhibited positive correlation age correlated each...

10.1080/08952841.2019.1697161 article EN Journal of Women & Aging 2019-11-26

Study Design; A retrospective observational study was performed. Purpose: We investigated the relationships between skeletal muscle mass, bone mineral density (BMD), and trabecular score (TBS) in patients with osteoporotic vertebral compression fractures (VCFs). Overview of Literature: The TBS has attracted attention as a measurement microarchitecture. It is derived from data obtained using dual-energy X-ray absorptiometry (DXA) reported indicator VCFs, its addition to Fracture Risk...

10.31616/asj.2020.0045 article EN cc-by-nc Asian Spine Journal 2020-09-02

Abstract Background Several authors have reported favorable results in low back pain (LBP) for patients with lumbar disc herniation (LDH) treated discectomy. However, detailed changes over time the characteristics and location of LBP before after discectomy LDH remain unclear. To clarify these points, we conducted an observational study to determine LDH, using a visual analog scale (VAS) bilaterally. Methods We included 65 by this study. A VAS was administered patient under 3 different...

10.1186/s12891-021-04015-z article EN cc-by BMC Musculoskeletal Disorders 2021-02-11

This study investigated the effect of romosozumab on bone union in a rat posterolateral lumbar fixation model. Posterolateral was performed 8-week-old male Sprague Dawley rats (n = 20). For grafting, autogenous (40 mg) harvested from spinous processes 10th thoracic vertebra until 2nd and implanted between intervertebral joints transverse 4th 5th vertebrae both sides. Rats were matched by body weight equally divided into two groups: R group (Evenity®, 25 mg/kg) control (C) (saline)....

10.1002/jor.25287 article EN Journal of Orthopaedic Research® 2022-01-28

Immunohistochemistry for tumor necrosis factor (TNF)-α in nucleus pulposus of adolescent patients with lumbar disc herniation.To examine whether an inflammatory cytokine is expressed the herniation.TNFα thought to play a crucial role radicular pain caused by herniation adult patients. However, expression TNFα has not been explored.Five samples from (age, 12-16 yr; n = 5) or controls requiring surgery other back problems 4; nonpainful scoliosis) were harvested during surgery. Nucleus...

10.1097/brs.0b013e3182739cb4 article EN Spine 2012-09-18

The purpose of this study was to investigate the long-term incidence lumbar disc degeneration and Modic changes in non-fused segments patients with adolescent idiopathic scoliosis (AIS) who previously underwent spinal fusion.Study subjects consisted 252 AIS fusion between 1968 1988. Of patients, 35 spine MRI whole X-ray examination. mean patient age at time follow-up 49.8 years, an average period 35.1 years. We classified into two groups based on lowest fused vertebra: H group whose vertebra...

10.22603/ssrr.1.2016-0017 article EN cc-by-nc-nd Spine Surgery and Related Research 2017-01-01

ABSTRACT The aim of this study was to investigate the local production proinflammatory cytokines, pain‐related sensory innervation dorsal‐root ganglia (DRG), and spinal changes in a rat model induced hip osteoarthritis (OA). Seventy‐five Sprague–Dawley rats were used, including 25 controls 50 injected into right joints (sham group, with µl sterile saline: N = 25; monosodium iodoacetate (MIA) saline 2 mg MIA: 25). We measured TNF‐α, immunoreactive (‐ir) neurons for calcitonin gene‐related...

10.1002/jor.24065 article EN Journal of Orthopaedic Research® 2018-06-11
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