A5023317506- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Connective tissue disorders research
- Marine Sponges and Natural Products
- Musculoskeletal pain and rehabilitation
- Synthetic Organic Chemistry Methods
- Marine Toxins and Detection Methods
- Aluminum Alloy Microstructure Properties
- Genetic factors in colorectal cancer
- Microstructure and Mechanical Properties of Steels
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Management of metastatic bone disease
- Shape Memory Alloy Transformations
- Synthesis and Biological Activity
- Pelvic and Acetabular Injuries
- Microstructure and mechanical properties
- Polymer Nanocomposites and Properties
- Congenital heart defects research
- Polymer crystallization and properties
- Aluminum Alloys Composites Properties
- Intermetallics and Advanced Alloy Properties
- Hip disorders and treatments
- Spinal Dysraphism and Malformations
Keio University Hospital
2022-2025
Keio University
2015-2025
Tokyo Women's Medical University
2018-2025
Institute for Conflict Research
2024
Hiroshima University
2024
Reaction Engineering International (United States)
2024
Shizuoka Red Cross Hospital
2014-2024
Saiseikai Shimonoseki General Hospital
2024
Aomori Public University
2024
National Institute of Infectious Diseases
2024
Abstract Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays strong female bias. By performing genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females ( P =6.89 × 10 −9 ) but not males =0.71). This IS also found in independent cohorts from the United States America and Japan (overall =2.15 −10 , OR=1.30 (rs6137473)). Unexpectedly, risk alleles were previously associated protection...
Patients with lumbar spinal stenosis (LSS) tend to bend forward relieve neurological symptoms. They therefore have a positive sagittal vertical axis (SVA). The importance of the SVA value is well known in field adult deformity; however, little about its impact on LSS. authors sought investigate spinopelvic alignment clinical outcome and health-related quality life (HRQOL) after decompression surgery for
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, affecting around 2% of adolescents worldwide. Genetic factors play an important role in its etiology. Using a genome-wide association study (GWAS), we recently identified novel AIS susceptibility loci on chromosomes 10q24.31 and 6q24.1. To identify more relating to severity progression, performed GWAS by limiting case subjects those with severe AIS. Through two-stage using total ∼12,000 Japanese subjects, variant,...
Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has strong genetic predisposition. Several associations between and single nucleotide polymorphisms (SNPs) have been reported; common SNPs the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase (TPH1), insulin-like growth factor (IGF1) are reported to be associated with Chinese. However, these not replicated so far. To confirm...
Abstract Adolescent idiopathic scoliosis (AIS) is a common disorder with strong genetic predisposition. Associations between AIS and single nucleotide polymorphisms (SNPs) in estrogen receptor genes have been reported. rs9340799 the gene for α ( ESR1 ) reported to be associated curve severity Japanese predisposition Chinese. In addition, rs1256120 β ESR2 However, sample sizes of these previous studies were small, associations SNPs not replicated. To examine association genes, we investigated...
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them locus on chromosome 6q24.1 that we by GWAS in Japanese cohort. The represented rs6570507 located within GPR126. To ensure AIS, conducted meta-analysis using eight cohorts from East Asia, Northern Europe USA. analysis included total 6,873 cases 38,916 controls...
In Brief Study Design. A retrospective case series. Objective. To assess whether a short fusion strategy is applicable when treating adolescent idiopathic scoliosis with Lenke type 5C curve by posterior correction and surgery using pedicle-screw constructs. Summary of Background Data. Previous studies have discussed the selection lower instrumented vertebra to best preserve motion segments obtain coronal balance. However, reports evaluating upper curves are not available. Methods. We...
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis AIS depend on curve progression, identifying factors related to progression important in its management. Although several genetic loci for occurrence are reported, no locus has been identified. To identify genes associated with we conducted genome-wide association study followed by replication using total 2,543 subjects who were evaluated the progression. We...
Study Design. Retrospective analysis of data collected across multiple centers. Objective. To develop machine learning models for predicting neurological outcomes one month postoperatively in patients with metastatic spinal tumors undergoing surgery, and to identify key factors influencing recovery. Summary Background Data. The increasing prevalence metastases has led a growing need surgical intervention address mechanical instability deficits. Predicting postoperative status, as assessed by...
A unique C2-symmetrical 4,4'-bis(7-hydroxy)indole alkaloid, dendridine (1), was isolated from an Okinawan marine sponge Dictyodendrilla sp., and the structure elucidated by spectroscopic data. Dendridine (1) exhibited antibacterial antifungal activities.
In Brief Study Design. A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression adolescent idiopathic scoliosis (AIS). Objective. To determine whether the 53 SNPs in white patients AIS are replicated Japanese AIS. Summary Background Data. Predicting is important clinical practice The a number genes. Associations have been reported, and used for test AIS; however, there has no replication their association. Methods. We...
The importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward relieve their neurological symptoms, i.e., they have a positive vertical axis (SVA). We hypothesized that the SVA associated LSS symptom related and should improve after surgery. However, little known about changes in patients decompression In this study authors aimed evaluate midterm radiographical spinopelvic surgery for determine factors influencing...
The purpose of the present study was to evaluate associations between changes in segmental vertebral coronal angulation (screw angulation) and overall height after anterior spinal growth tethering for treatment idiopathic scoliosis compare rates change using preoperative Sanders stage.Patients with who underwent 2012 2016 had ≥2 years follow-up were retrospectively studied. We calculated each segment's screw rate (degrees/month) patient's velocity (cm/month) visits (3 12 visits/patient)...
Abstract Background In Japan, carbapenem-resistant Enterobacterales (CRE) infections were incorporated into the National Epidemiological Surveillance of Infectious Diseases (NESID) in 2014, necessitating mandatory reporting all CRE cases. Subsequently, pathogen surveillance was initiated 2017, which involved collection and analysis isolates from reported cases to assess carbapenemase gene possession. this surveillance, is defined as (i) minimum inhibitory concentration (MIC) meropenem ≥2...
Papilledema is optic disc swelling due to intracranial hypertension, which leads progressive visual impairment. We report a rare case of papilledema with ectopic orbital calcification during hemodialysis. A 34-year-old woman low body weight who was undergoing long-term hemodialysis presented in both eyes, and her vision gradually deteriorated over the course six months. The best corrected acuity 20/16 right eye 20/500 left eye, fundus examination revealed significant field testing nasal...
We describe a method for quickly and easily measuring the size of small particles in suspensions. This uses self-mixing laser Doppler measurement with laser-diode-pumped, thin-slice LiNdP(4)O(12) extremely high optical sensitivity. The average Brownian motion is determined by Lorentz fitting measured power spectrum modulated light resulting from motion. dependence spectra on particle concentration was quantitatively identified results systematic investigation polystyrene latex different...