A5044443953- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Spinal Dysraphism and Malformations
- Spinal Hematomas and Complications
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Pain Mechanisms and Treatments
- Parkinson's Disease and Spinal Disorders
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tumor Diagnosis and Treatments
- Otolaryngology and Infectious Diseases
- Musculoskeletal pain and rehabilitation
- Neurogenetic and Muscular Disorders Research
- Orthopedic Surgery and Rehabilitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Bone health and treatments
- Connective tissue disorders research
- Gout, Hyperuricemia, Uric Acid
- Neurosurgical Procedures and Complications
Japanese Red Cross Narita Hospital
2018-2021
Chiba Aoba Municipal Hospital
2012-2021
Chiba University
2007-2019
Teikyo University Chiba Medical Center
2016-2017
A retrospective multicenter survey.To investigate the perioperative complications of oblique lateral interbody fusion (OLIF) surgery.OLIF has been widely performed to achieve minimally invasive, rigid lumbar fusion. The associated are not yet well described.The participants were patients who underwent OLIF surgery under diagnosis degenerative diseases between April 2013 and May 2015 at 11 affiliated medical institutions. collected data classified into intraoperative early-stage postoperative...
Prospective case series.To examine the clinical efficacy of mini-open anterior retroperitoneal lumbar interbody fusion: oblique lateral fusion (OLIF) for degenerated spinal kyphoscoliosis.The existing surgical procedures treatment kyphotic deformity, including Smith-Petersen osteotomy, pedicle subtraction and vertebral column resection procedures, are invasive in nature. Extreme to provide less deformity has been reported, but complications nerve psoas muscle injury have noted. In current...
<h3>Importance</h3> The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. <h3>Objective</h3> To determine whether early surgical decompression results in better motor recovery than delayed treatment patients with incomplete SCI associated preexisting canal stenosis but without bone injury. <h3>Design, Setting, and Participants</h3> This multicenter randomized clinical trial was conducted 43 tertiary referral centers Japan from December 2011 through November...
Granulocyte colony-stimulating factor (G-CSF) is a protein that stimulates differentiation, proliferation, and survival of granulocytic lineage cells. Recently, neuroprotective effect G-CSF was reported in model cerebral infarction. The aim the present study to elucidate potential therapeutic for spinal cord injury (SCI) mice. We found against glutamate-induced cell death cerebellar granule neurons vitro. Moreover, we used mouse compressive SCI examine vivo. Histologic assessment with cresyl...
Background Granulocyte colony-stimulating factor (G-CSF) is a protein that stimulates differentiation, proliferation, and survival of cells in the granulocytic lineage. Recently, neuroprotective effect G-CSF was reported model cerebral infarction we previously same studies murine spinal cord injury (SCI). The aim present study to elucidate potential therapeutic for SCI rats. Methods Adult female Sprague-Dawley rats were used study. Contusive introduced using Infinite Horizon Impactor...
The aim of this study was to evaluate whether transplantation human bone marrow stromal cell-derived Schwann cells (hBMSC-SC) promotes functional recovery after contusive spinal cord injury adult rats. Human (hBMSC) were cultured from patients and induced into in vitro. cell phenotype confirmed by immunocytochemistry. Growth factors secreted hBMSC-SC detected using cytokine antibody array. Immunosppressed rats laminectomized their cords contused NYU impactor (10 g, 25 mm). Nine days injury,...
An open-labeled multicenter prospective nonrandomized controlled clinical trial.To confirm the feasibility of using granulocyte colony-stimulating factor (G-CSF) for treatment acute spinal cord injury (SCI).We previously reported that G-CSF promotes functional recovery after compression-induced SCI in mice. On basis these findings, we conducted a trial to assess therapy patients with SCI.The ran from August 2009 March 2011, and included 41 treated within 48 hours onset. Informed consent was...
Abstract The transplantation of rodent Schwann cells (SCs) provides anatomical and functional restitution in a variety spinal cord injury (SCI) models, supporting the recent translation SCs to phase 1 clinical trials for human SCI. Whereas (Hu)SCs have been examined experimentally complete SCI transection paradigm, date reported behavior when transplanted after clinically relevant contusive has restricted use SCs. Here, xenotransplant, survival, biodistribution, proliferation tumorgenicity...
The authors previously reported that Schwann cells (SCs) could be derived from bone marrow stromal (BMSCs) in vitro and they promoted axonal regeneration of completely transected rat spinal cords vivo. aim the present study is to evaluate efficacy transplanted BMSC-derived SCs (BMSC-SCs) a model cord contusion, which relevant clinical injury.Bone were cultured as plastic-adherent GFPtransgenic rats. BMSC-SCs BMSCs with sequential treatment using beta-mercaptoethanol, all-trans-retinoic acid,...
Condoliase is a newly approved drug that improves symptoms associated with lumbar disk herniation (LDH) by intradiscal administration. This study aimed to evaluate the mid-term outcomes of condoliase injection, examine adverse events, including cases required surgery after administration, and verify in which could be effective.We enrolled patients LDH who were treated conservatively for at least six weeks received condoliase. We assessed visual analog scale (VAS) score, Japanese Orthopaedic...
Study Design Retrospective case series. Purpose To elucidate the impact of postoperative occiput–C2 (O–C2) angle change on subaxial cervical alignment. Overview Literature In occipito–upper fixation surgery, it is recommended that O–C2 should be set larger than preoperative value postoperatively. Methods The present study included 17 patients who underwent spine (above C4) posterior surgery for atlantoaxial subluxation various etiologies. Plain lateral radiographs in a neutral position at...
Hemorrhage caused by spinal cord hemangioblastoma is rare, usually presenting as a subarachnoid hemorrhage. Intramedullary hemorrhage an extremely rare manifestation of hemangioblastoma. Forty-year-old Japanese male patient presented with acute paraplegia. Magnetic resonance (MR) imaging the revealed intramedullary An mass lesion was detected at 8th thoracic vertebral level (T8) in gadolinium enhanced-MR image. Spinal angiography tumor stain T8. Therefore we diagnosed problem One month after...