A5061020530- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Spinal Cord Injury Research
- Musculoskeletal pain and rehabilitation
- Mesenchymal stem cell research
- Scoliosis diagnosis and treatment
- Nerve injury and regeneration
- Osteoarthritis Treatment and Mechanisms
- Pelvic and Acetabular Injuries
- Neurogenesis and neuroplasticity mechanisms
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Nerve Injury and Rehabilitation
- Bone Tumor Diagnosis and Treatments
- Pluripotent Stem Cells Research
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Analysis
- Knee injuries and reconstruction techniques
- Venous Thromboembolism Diagnosis and Management
- Spinal Dysraphism and Malformations
- Bone health and osteoporosis research
- Heterotopic Ossification and Related Conditions
- Musculoskeletal synovial abnormalities and treatments
- Pregnancy-related medical research
Hirosaki University
2016-2025
Hirosaki University Hospital
2021
Open Evidence
2021
Level (Czechia)
2021
Weatherford College
2021
Aomori Rosai Hospital
2011-2017
Hirosaki National Hospital
2016
University of Miami
2013
Keio University
2009-2010
Various types of induced pluripotent stem (iPS) cells have been established by different methods, and each type exhibits biological properties. Before iPS cell-based clinical applications can be initiated, detailed evaluations the cells, including their differentiation potentials tumorigenic activities in contexts, should investigated to establish safety effectiveness for cell transplantation therapies. Here we show directed neural murine examine therapeutic potential a mouse spinal cord...
<h3>Importance</h3> The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. <h3>Objective</h3> To determine whether early surgical decompression results in better motor recovery than delayed treatment patients with incomplete SCI associated preexisting canal stenosis but without bone injury. <h3>Design, Setting, and Participants</h3> This multicenter randomized clinical trial was conducted 43 tertiary referral centers Japan from December 2011 through November...
Transplantation of neural stem/progenitor cells (NS/PCs) following the sub-acute phase spinal cord injury (SCI) has been shown to promote functional recovery in rodent models. However, types most effective for treating SCI have not clarified. Taking advantage our recently established neurosphere-based culture system ES cell-derived NS/PCs, which primary neurospheres (PNS) and passaged secondary (SNS) exhibit neurogenic gliogenic potentials, respectively, here we examined distinct effects...
To investigate potential cures for spinal cord injury (SCI), several researchers have transplanted neural stem/progenitor cells (NS/PCs) into the injured by different procedures, including intralesional (IL), intrathecal (IT), and intravenous (IV) injection. However, there are no reports quantifying or comparing number of successfully to lesion site each procedure in vivo. The purpose present study was determine optimal method cell transplantation SCI terms grafted survival safety. For this...
Radiographic findings may provide clues to the underlying cause of neck symptoms. However, these associations remain controversial. This study investigates association between roentgenographic cervical spine and symptoms in a Japanese community population.A total 762 volunteers participated this study. Sagittal radiographs were taken questionnaire about presence visual analog scale (VAS) for pain or stiff shoulder was completed. The sagittal alignment (C2-C7) degenerative index measured from...
Abstract Introduction Spinal cord injury (SCI) is a devastating and remains one of the largest medical social burdens because its intractable nature. According to recent advances in stem cell biology, possibility spinal regeneration functional restoration has been suggested by introducing appropriate cells. Multilineage-differentiating stress enduring (Muse) cells are type nontumorigenic endogenous reparative cell. The positive results Muse transplantation for SCI was shown previously. As...
Study Design A radiographic study in 111 patients using radiographs was conducted. Objective To clarify whether the modified laminoplasty with C3 laminectomy preserving semispinalis cervicis (SSC) inserted into C2 could maintain postopertive range of motion (ROM) and sagittal alignment compared conventional C3-C7 reattaching muscle to C2. Summary Background Data Intraoperative injury SSC is relevant significant loss ROM malalignment after laminoplasty. expose lamina, however, not be...
A clinical and cohort study.The first purpose of this study was to investigate the standard value a simple foot tapping test (FTT) in large healthy population. The second elucidate validity FTT as quantitative assessment lower extremity motor function for cervical compressive myelopathy.Several performance tests have been reported objective assessments severity myelopathy. is simplest easiest method analysis limb dysfunction upper neuron diseases. However, there were few studies about...
It has been reported that female rats have a sex-related advantage in functional recovery and neuroprotection after spinal cord injury (SCI). However, the association between anxiety neurological function SCI male remains unclear. The aim of this study was to examine differences dysfunction adult C57/BL6 mice. After laminectomy at 10th thoracic level, contusive induced. sham group received only T10 laminectomy. Behavior testing (anxiety, motor/sensory function) performed for 6 weeks SCI....
Objective: We compared screening methods for asymptomatic venous thromboembolism (VTE) in patients with acute spine and spinal cord injuries (SCI). Patients were screened by D-dimer monitoring alone (DS group) or combined ultrasonography (DUS group).Design: Prospective cohort study.Setting: One department of a university hospital Japan.Participants: 114 treated SCI between 2011 2017.Interventions: N/A.Outcome Measures: D-dimers measured upon admission 1, 3, 5, 7, 14 days thereafter....
The surface of pure titanium (Ti) shows decreased histocompatibility over time; this phenomenon is known as biological ageing. UV irradiation enables the reversal ageing through photofunctionalisation, a physicochemical alteration surface. Ti implants are sterilised by in dental surgery. However, orthopaedic biomaterials usually composed alloy Ti6Al4V, for which antibacterial effects unconfirmed. Here we evaluated bactericidal and antimicrobial treating Ti6Al4V with lower briefer dose than...
Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage. To explore epigenetic control of features MSCs, we treated MSCs obtained yellow ligament (OYL) patients and non-OYL DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine (5AdC). We compared groups (untreated 5AdC) OYL by genome-wide microarray analysis. Next, used methylated immunoprecipitation combined quantitative real-time PCR to assess gene...
The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with fragility are unclear. We aimed to investigate the between BMLs, mineral density (BMD), markers in women radiographic evidence KOA. This single-center cross-sectional study a Japanese population included 266 KOA, which was defined as Kellgren-Lawrence grade < 2. All participants underwent coronal sagittal T2-weighted fat-suppressed magnetic resonance imaging right knee. BML severity scored...
Ultraviolet (UV) light-mediated photofunctionalisation is known to improve osseointegration of pure titanium (Ti). However, histological examination alloy (Ti6Al4V), which frequently applied in orthopaedic and dental surgery, has not yet been performed. This study examined the photofunctionalised Ti6Al4V implants.Ti implants were treated with UV light, chemical composition contact angle on surfaces evaluated confirm photofunctionalisation. The inserted into femurs rats, rats killed two or...
Basic experiments in a mouse model of ossification the posterior longitudinal ligament (OPLL).To assess osteogenic potential mesenchymal stem cells (MSCs) obtained from muscle and adipose tissue Tiptoe-walking (ttw) mice, which cervical OPLL compresses spinal cord causes motor sensory dysfunction.In humans, MSCs have been implicated pathogenesis OPLL. Cervical ttw mice chronic compression cord. Few studies compared MSC with behavioral changes an animal model.We characteristics (4 to 20 weeks...
Multilineage-differentiating stress-enduring (Muse) cells are endogenous pluripotent stem that can be isolated based on stage-specific embryonic antigen-3 (SSEA-3), a cell-surface marker. However, their capacities for survival, neurotrophic factor secretion, and neuronal glial differentiation unclear in rodents. Here we analyzed mouse adipose tissue-derived Muse vitro. We collected mesenchymal (MSCs) from C57BL/6 J tissue separated SSEA-3 + , namely cells, – non-Muse to assess...
Abstract Background This cross-sectional study sought to determine the neck-shoulder stiffness/low back pain (NSS/LBP) comorbidity rate in a Japanese community population and compare quality of life (QOL) individuals with comorbid NSS/LBP, asymptomatic individuals, those symptoms NSS or LBP alone. Methods The sample included 1122 subjects (426 men; 696 women) previous 3 months, were grouped according NSS, LBP, (Comorbid), no (NP). They completed MOS 36-Item Short-Form Health Survey (SF-36)....