A5080530425- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Spinal Dysraphism and Malformations
- Trauma Management and Diagnosis
- Neurogenesis and neuroplasticity mechanisms
- Cerebral Palsy and Movement Disorders
- Mesenchymal stem cell research
- Scoliosis diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve Injury and Rehabilitation
- Galectins and Cancer Biology
- Facial Trauma and Fracture Management
- Trauma and Emergency Care Studies
- Stroke Rehabilitation and Recovery
- Signaling Pathways in Disease
- Pelvic and Acetabular Injuries
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Craniofacial Disorders and Treatments
- Head and Neck Surgical Oncology
- Shoulder and Clavicle Injuries
Keio University
2007-2025
Keio University Hospital
2005-2025
Keiyu Orthopedic Hospital
2025
Murayama Medical Center
2017-2024
National Hospital Organization
2017-2024
Kanagawa Prefectural Police Department
2024
keiyu Hospital
2024
Spinal Injuries Center
2022
Renault (France)
2021
Shizuoka Red Cross Hospital
2018
Neural stem/progenitor cells (NSPCs) hold promise in neural tissue replacement therapy after spinal cord injury. However, understanding the survival time of grafted NSPCs and determining extent migration away from transplantation sites are essential for optimizing treatment regimens. Here, we used vivo bioluminescence imaging to noninvasively assess residence transplanted at injury living animals, histologic analyses cell integration morphology. Third-generation lentiviral vectors enabled...
Many therapeutic interventions using neurotrophic factors or pharmacological agents have focused on secondary degeneration after spinal cord injury (SCI) to reduce damaged areas and promote axonal regeneration functional recovery. Hepatocyte growth factor (HGF), which was identified as a potent mitogen for mature hepatocytes mediator of inflammatory responses tissue injury, has recently been highlighted angiogenic in the central nervous system (CNS). In present study, we revealed that extent...
Abstract We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can contribute to repair injured spinal cord in adult rats and monkeys. In some cases, however, most transplanted adhered cavity wall failed migrate integrate into host cord. this study we focused on chondroitin sulfate proteoglycan (CSPG), a known constituent glial scars is strongly expressed after injury (SCI), as putative inhibitor NSPC migration vivo . hypothesized digestion CSPG by...
Human uterine endometrium exhibits unique properties of cyclical regeneration and remodeling throughout reproductive life also is subject to endometriosis through ectopic implantation retrogradely shed endometrial fragments during menstruation. Here we show that functional can be regenerated from singly dispersed human cells transplanted beneath the kidney capsule NOD/SCID/gamma(c)(null) immunodeficient mice. In addition endometrium-like structure, hormone-dependent changes, including...
Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because neurofunctional and anatomic differences between primates. In present study, development histopathologic changes functional deficits were assessed quantitatively after mild, moderate, severe contusive injuries common marmosets. Contusive SCI was induced by dropping one three different weights (15, 17, or 20 g) at...
Transplantation of neural stem/progenitor cells (NS/PCs) following the sub-acute phase spinal cord injury (SCI) has been shown to promote functional recovery in rodent models. However, types most effective for treating SCI have not clarified. Taking advantage our recently established neurosphere-based culture system ES cell-derived NS/PCs, which primary neurospheres (PNS) and passaged secondary (SNS) exhibit neurogenic gliogenic potentials, respectively, here we examined distinct effects...
Retrospective study of new muscle-preserving exposure techniques and their application to posterior cervical spine surgery.To describe for the spine, demonstrate how a variety surgeries varying pathologies allows preservation mobility stability.Although surgical approaches through intermuscular planes have been applied extremities anterior spinal column, our knowledge, they yet be spine.We used since 2000, applying them selective mono laminoplasty (73 patients) myelopathy, intervertebral...
In spinal cord injury, axonal disruption results in motor and sensory function impairment. The evaluation of fibers is essential to assess the severity injury efficacy any treatment protocol, but conventional methods such as tracer injection brain parenchyma are highly invasive require histological evaluation, precluding clinical applications. Previous advances magnetic resonance imaging technology have led development diffusion tensor tractography (DTT) a potential modality perform vivo...
Delayed transplantation of neural stem/progenitor cells (NS/PCs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. To enhance after NS/PC transplantation, we focused on galectin-1, a carbohydrate-binding protein with pleiotropic roles cell growth, differentiation, apoptosis, neurite outgrowth. Here, to determine combined therapeutic effect galectin-1 injury (SCI), human NS/PCs were transfected by lentivirus green fluorescent (GFP), (Gal-NS/PCs) or GFP...
In the current aging society, there has been a marked increase in incidence of cervical spinal cord injury (CSCI) without major bone injury. This multi-center study aimed to identify predictors neurological improvement elderly patients with CSCI The participants were 591 aged ≥65 years and minimum follow-up period three months. Neurologic status was defined using American Spinal Injury Association (ASIA) impairment scale (AIS). Univariate multi-variate analyses performed prognostic factors...
Study Design. A retrospective single-center study. Objective. The aim of this study was to evaluate the compensatory mechanism cervical lordosis (CL), changes in sagittal alignment, and range motion (ROM) after muscle-preserving selective laminectomy (SL). Summary Background Data. CL increases as a for adjustment balance or horizontal gaze. However, laminoplasty invades causes kyphosis higher T1 (C7) slope patients. Methods. SL is posterior surgery selecting decompression laminae without...
Although traumatic cervical spine injuries in older adults are commonly caused by minor traumas, such as ground-level falls, their prognosis is often unfavorable. Studies examining the clinical characteristics of according to external cause injury lacking. This study included 1512 patients ≥ 65 years age with registered a Japanese nationwide multicenter database. The relationship between causes and characteristics, well factors causing unfavorable outcomes at were retrospectively reviewed...
Study Design Retrospective multi-institutional study. Objectives Although previous studies have evaluated the surgical outcomes of laminoplasty in patients with cervical ossification posterior longitudinal ligament (OPLL), long-term results remain unclear. The purpose this study is to assess more than 10 years post-surgery and identify factors that affect prognosis. Methods Eighty-four OPLL a minimum 10-year follow-up after surgery were divided into good group 50% improvement recovery rate...
Abstract This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included aged ≥ 65 years traumatic SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 (mean follow-up: 20.1 months) were examined 47 had major risks admission. One-year rate, median survival time, recovery, activities daily...
A retrospective study at a single academic institution.
Study Design. Retrospective multicenter study. Objective. We aimed to assess the outcomes following posterior cervical decompression for spondylotic myelopathy (CSM) in a large sample of patients older than 80 years. Summary Background Data. Although age is predictor surgical CSM, most previous studies have only investigated effect aged 65 75 years, and remain unclear patients. Methods. Patients 50 years who underwent CSM were enrolled from 17 institutions. The grouped into young–old group...
Retrospective Cohort Study.The purpose of this study was to investigate the prognosis respiratory function in elderly patients with cervical spinal cord injury (SCI) and identify predictive factors.We included 1353 cases SCI collected from 78 institutions Japan. Patients who required early tracheostomy ventilator management those developed complications were defined as disability group. Patients' background characteristics, mechanism, form, neurological disability, complications, treatment...
For older patients with decreased reserve function, traumatic cervical spine injuries frequently lead to early mortality. However, the prognostic factors for mortality remain unclear. This study included aged ≥65 years and hospitalized treatment of in 78 hospitals between 2010 2020. Early was defined as death within 90 days after injury. We evaluated relationship following factors: age, sex, body mass index, history drinking smoking, injury mechanisms, presence a fracture dislocation,...
Transplantation of human neural stem/progenitor cells (hNSPCs) is a promising method to regenerate tissue from damage and recover function in various neurological diseases including brain ischemia. Galectin-1(Gal1) lectin that expressed damaged areas after Here, we characterized the detailed Gal1 expression pattern an animal model After ischemia, was reactive astrocytes within around infarcted region, its diminished over time. Previously, showed infusion protein (hGal1) resulted functional...