A5040927651- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- T-cell and Retrovirus Studies
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- HIV/AIDS drug development and treatment
- Lipid metabolism and disorders
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Cancer Research and Treatments
- RNA modifications and cancer
- Cell death mechanisms and regulation
Osaka University
1992-2025
Kumamoto University
2016-2025
Khon Kaen University
2010-2023
Johns Hopkins University Center for AIDS Research
2007-2022
Open Evidence
2022
Level (Czechia)
2022
Kyushu University
2011-2022
Mae Fah Luang University
2022
Joint Research Center
2022
Wakunaga (Japan)
2021
Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2WT/WT has yet been established. We explore epigenome and transcriptome in EZH2WT/Mu aggressive lymphomas show that mutual interference compensatory function co-expressed EZH1 EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin gene expression signatures. Direct comparison leading compounds introduces potency...
In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated phenotype (SASP) leads to cancer progression and chemoresistance. However, role of CAFs in metastatic lesions molecular mechanism inflammation-related SASP induction are not well understood. We show that pro-inflammatory cytokine-driven EZH2 downregulation maintains by demethylating H3K27me3 marks...
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly germinal center (GC) cells. To investigate function of lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells Bcl6-deficient (Bcl6−/−RM). Lymphogenesis primary lymphoid tissues Bcl6−/−RM is normal, produced control levels IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found these mice. This...
Strategies to inhibit metastasis have been mainly unsuccessful in part due insufficient mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like protein 2 (ANGPTL2) metastatic progression. In mice, Angptl2 has implicated inflammatory carcinogenesis but it not studied human tumors. patients with lung cancer, elevated levels ANGPTL2 expression tumor cells within primary were associated a reduction period disease-free survival after surgical resection....
Abstract Deep learning-based image segmentation has allowed for the fully automated, accurate, and rapid analysis of musculoskeletal (MSK) structures from medical images. However, current approaches were either applied only to 2D cross-sectional images, addressed few structures, or validated on small datasets, which limit application in large-scale databases. This study aimed validate an improved deep learning model volumetric MSK hip thigh with uncertainty estimation clinical computed...
Recovery in central nervous system disorders is hindered by the limited ability of vertebrate to regenerate lost cells, replace damaged myelin, and re-establish functional neural connections. Cell transplantation repair an active area research, with goal reducing deficits. Recent animal studies showed that cells hematopoietic stem cell (HSC) fraction bone marrow transdifferentiated into various nonhematopoietic lineages. We employed a mouse model spinal cord injury directly transplanted HSCs...
Transplantation of neural stem/progenitor cells (NS/PCs) following the sub-acute phase spinal cord injury (SCI) has been shown to promote functional recovery in rodent models. However, types most effective for treating SCI have not clarified. Taking advantage our recently established neurosphere-based culture system ES cell-derived NS/PCs, which primary neurospheres (PNS) and passaged secondary (SNS) exhibit neurogenic gliogenic potentials, respectively, here we examined distinct effects...
Granulocyte colony-stimulating factor (G-CSF) is a protein that stimulates differentiation, proliferation, and survival of granulocytic lineage cells. Recently, neuroprotective effect G-CSF was reported in model cerebral infarction. The aim the present study to elucidate potential therapeutic for spinal cord injury (SCI) mice. We found against glutamate-induced cell death cerebellar granule neurons vitro. Moreover, we used mouse compressive SCI examine vivo. Histologic assessment with cresyl...
Summary Chronic inflammation as a risk factor for cancer development is driven in part by monocyte/macrophages, which many cancers exhibit pro-tumorigenic activity. In this study we identified elevation CD14+CD16+, minor blood monocyte subpopulation cholangiocarcinoma (CCA) patients, compared to normal and biliary disease patient specimens. Tumour association was suggested the observation that elevated level decreased after tumour resection. Moreover, of CD14+CD16+ monocytes CCA correlated...
Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research. In this study, we generated Rag‐2/Jak3 double‐deficient (Rag‐2 −/− Jak3 ) with a C57/BL6 Balb/c genetic background compared the lymphohematopoietic engraftment rate. Human cord blood‐derived CD34 + hematopoietic cells were successfully engrafted into Rag‐2 mice; however, rate was far lower mice. Transplantation of peripheral blood mononuclear resulted same tendency. Thus, offers superior capacity than...