A5064857503- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- Occupational Health and Safety Research
- Neurofibromatosis and Schwannoma Cases
- Radiation Dose and Imaging
- Pluripotent Stem Cells Research
- Radiation Therapy and Dosimetry
- Nerve injury and regeneration
- Radioactivity and Radon Measurements
- Spinal Hematomas and Complications
- Neurogenesis and neuroplasticity mechanisms
- Head and Neck Surgical Oncology
- Stroke Rehabilitation and Recovery
- Cancer Mechanisms and Therapy
- Health Promotion and Cardiovascular Prevention
- Multiple and Secondary Primary Cancers
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Spinal Dysraphism and Malformations
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
Keio University
1975-2025
Murayama Medical Center
2021-2025
National Hospital Organization
2021-2025
Keio University Hospital
2016-2022
Renault (France)
2021
Radiation Effects Research Foundation
2012
Duke University Hospital
2008
Duke Medical Center
2008
Ogikubo Hospital
2003
Institute of Industrial Ecology
1998
Our group has conducted extensive basic and preclinical studies of the use human induced pluripotent cell (iPSC)-derived neural stem/progenitor (hiPSC-NS/PC) grafts in models spinal cord injury (SCI). Evidence from animal experiments suggests this approach is safe effective. We are preparing to initiate a first-in-human clinical study hiPSC-NS/PC transplantation subacute SCI.NS/PCs were prepared at Good Manufacturing Practice-grade processing facility Osaka National Hospital using...
Neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem (hiPSCs) are considered to be a promising cell source for cell-based interventions that target CNS disorders. We previously reported transplanting certain hiPSC-NS/PCs in the spinal cord results tumor-like overgrowth of and subsequent deterioration motor function. Remnant immature should removed or into more mature types avoid adverse effects hiPSC-NS/PC transplantation. Because Notch signaling plays role...
Treatment involving regenerative medicine for chronic spinal cord injury (SCI) is difficult due to phase-dependent changes in the intraspinal environment. We previously reported that treatment with a gamma-secretase inhibitor (GSI), which inhibits Notch signaling, promotes differentiation into mature neurons human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation subacute SCI. Here, we evaluated efficacy of GSI-treated hiPSC-NS/PC treating SCI,...
Section:ChooseTop of pageAbstract <<EPITHELIAL PROGENITOR CEL...miRNAs AND LUNG DEVELOPME...miRNAs AS POTENTIAL THERA...ReferencesCITING ARTICLES
Cell-based therapy targeting spinal cord injury (SCI) is an attractive approach to promote functional recovery by replacing damaged tissue. We and other groups have reported the effectiveness of transplanting neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem (hiPSCs) in SCI animal models for neuronal replacement. Glial replacement additional tissue repair; however, lack robust procedures drive iPSCs into NS/PCs which can produce glial has hindered development...
Few studies have identified factors that predict return to work after stroke in Japan. Our aim this study was determine the predictors of Japan.We performed a retrospective cohort on association between patients' characteristics at admission and 230 first-stroke patients, adjusting for potential confounding factors. The patients were all aged younger than 65 years working, students, or housewives time their stroke. Return evaluated by follow-up questionnaire. Data analyzed using forward...
Dried citrus peels (Chimpi) is one of the most common natural medicines with qi (energy flow) rectifying and shi (dampness) drying actions, which originates from Citrus unshiu, and/or C. reticulata according to definition pharmacopoeiae Japan China. In this study, pharmacological effects their extracts major chemical constituents hesperidin its aglycone hesperetin on anxiety were examined an model elevated open-platform test using ICR male mice (6-week-old) total duration freezing was...
<title>Abstract</title> <bold>Study Design</bold>: Retrospective cohort study <bold>Objectives</bold>: Ventrally located cervical spinal meningiomas present significant surgical challenges due to their proximity the cord and nerve roots. This aimed evaluate outcomes of these tumors resected via posterior approach compare them with dorsolaterally meningiomas. <bold>Setting</bold>: The single institution in Japan. <bold>Methods</bold>: A retrospective review was conducted on 39 patients who...
Retrospective cohort study. To evaluate the effect of discrepancies between sacral and pelvic obliquity on postoperative disk wedging below lower instrumented vertebra in Lenke type 5 adolescent idiopathic scoliosis (AIS). Previous studies have not fully explored outcomes patients with AIS. Data from 35 AIS (mean age, 14.7±1.8 years) followed for a minimum years were retrospectively analyzed. We investigated coronal (S angle) (P radiographic parameters. The angle S P angles was defined as...
Study Design Retrospective multi-institutional study. Objectives Although previous studies have evaluated the surgical outcomes of laminoplasty in patients with cervical ossification posterior longitudinal ligament (OPLL), long-term results remain unclear. The purpose this study is to assess more than 10 years post-surgery and identify factors that affect prognosis. Methods Eighty-four OPLL a minimum 10-year follow-up after surgery were divided into good group 50% improvement recovery rate...
With the aim of accurately assessing effects radiation exposure in Japanese atomic-bomb survivors, Radiation Effects Research Foundation has, over several decades, conducted studies Life Span Study (LSS) cohort, comprising 93 000 survivors and 27 controls.
This report studies 100 cases of occupational bladder cancer which were reported between 1949 and 1970 by large companies producing dye. It is estimated that in fact a great many more than may have developed during the 56 years from 1914 to 1970, as this period corresponds with beginning dye production termination benzidine beta-naphthylamine manufacture Japan. New tumour should diminish significantly future Japan on account prohibition benzidine. However, it important follow-up continuously...
To study the magnetic resonance (MR) imaging features of intradural nerve roots in avulsion injury cervical roots.Presurgical gadolinium-enhanced MR was performed 27 consecutive patients. The images were evaluated for enhancement and spinal cord surface at root entry zone ("root stump" enhancement) by two radiologists, who blinded to clinical information. Intradural classified as enhanced, normal, or not visible. Root stumps enhanced normal. results compared with continuity studies...
A retrospective comparative study.This study aimed to evaluate the radiographical changes in cervical sagittal alignment (CSA) and clinical outcomes after tumor resection using a posterior unilateral approach without spinal fixation for patients with dumbbell-shaped schwannoma (DS).Seventy-three DS who were followed up at least 2 years included. The Eden classification was used designate types of DS. CSA range motion (ROM) analyzed radiographs. assessed Japanese Orthopaedic Association (JOA)...
To study the role assumed by epidemiology in occupational health literature and characterise its change over years.A bibliometric was conducted with a MEDLINE search to evaluate 9024 articles published eight representative journals for period 1980-93. Articles related were found descriptors indexed their numbers proportions among all tabulated period.The proportion of source items as descriptor increased threefold from 7.9% (42/534) 1980 25% after 1990. Epidemiology most frequently...
Pregnant women are exempted from the current seatbelt legislation in Japan despite fact that use is essential to reduce risk of fatalities for these and their fetuses car crashes.To examine factors might influence during pregnancy.A cross sectional study, with data collected via an anonymous, self administered questionnaire at obstetric clinics suburban areas Japan. Altogether 880 pregnant receiving prenatal care July 2001 were recruited. The relative effects pregnancy estimated using...
Study Design Retrospective multicenter study. Objectives To investigate surgical outcomes following posterior decompression for cervical ossification of the longitudinal ligament (OPLL) when performed by board-certified spine (BCS) or non-BCS (NBCS) surgeons. Methods We included 203 patients with OPLL who were followed a minimum 1 year after surgery. Demographic information, medical history, and imaging findings collected. Clinical assessed preoperatively at final follow-up using Japanese...
The term "late-onset hypogonadism (LOH)" is recommended to express the symptoms in middle-aged males with decreased testosterone. Although androgen replacement therapy (ART) might be an effective way manage LOH, risk of testosterone supplementation elderly men still concerned. On other hand, avoid adverse effects ART, Kampo medicine (traditional Chinese-Japanese medicine) often a first choice treat LOH Japan. However, their pharmacological studies are few. In this study, castrated mice was...
Journal Article Radiation effects on cancer risks in the life span study cohort Get access Kazunori Kodama, Kodama * Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minamiku, Hiroshima 732-0815, Japan *Corresponding author: kodama@rerf.or.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Kotaro Ozasa, Ozasa Hiroaki Katayama, Katayama Roy E. Shore, Shore Toshiteru Okubo Protection Dosimetry, Volume 151, Issue 4, October 2012, Pages 674–676,...
Retrospective cohort study.Intraspinal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is often misdiagnosed preoperatively as schwannoma or meningioma because its imaging characteristics are not well understood. As postoperative prognosis differs among the 3 lesions, predicting probability of SFT/HPC essential. Thus, this study investigates compared with those and evaluates surgical outcomes.The preoperative findings, resection extent, recurrence regrowth rates, neurological...