A5009341567- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Spinal Dysraphism and Malformations
- Water Quality Monitoring Technologies
- Parkinson's Disease and Spinal Disorders
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Bone Tissue Engineering Materials
- Orthopedic Infections and Treatments
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- Anesthesia and Pain Management
- Spinal Cord Injury Research
- Meningioma and schwannoma management
- Underwater Vehicles and Communication Systems
- Surgical site infection prevention
- Bone Tumor Diagnosis and Treatments
- Nerve injury and regeneration
- Tendon Structure and Treatment
- Neurogenesis and neuroplasticity mechanisms
International University of Health and Welfare
2017-2025
Keio University
2015-2025
Mita Hospital
2017-2023
Edogawa Hospital
2021-2023
Hull York Medical School
2023
Kansai Medical University
2022
Teikyo University Chiba Medical Center
2022
Osaka University
2022
Kyushu University Beppu Hospital
2022
Nagoya City University
2017-2022
Retrospective case series on long-term follow-up results of original expansive open-door laminoplasty for cervical myelopathy due to spondylosis (CSM) and ossification posterior longitudinal ligament (OPLL).To elucidate efficacy problems improve future surgical outcomes.Little information is available outcomes without grafts, implants, or instruments.The study group included 80 patients who underwent were followed minimum 10 years. Clinical results, including Japanese Orthopedic Association...
Oxidative stress has been reported to be involved in numerous human diseases, including musculoskeletal disorders such as osteoarthritis. However, the interaction between intervertebral disc (IVD) degeneration and oxidative is not well understood. The purpose of present study was elucidate contribution IVD efficacy antioxidant treatment for degenerative discs.The expression level an marker, nitrotyrosine, assessed by immunohistochemistry Western blotting. For evaluating intracellular...
Neural stem/progenitor cells (NSPCs) hold promise in neural tissue replacement therapy after spinal cord injury. However, understanding the survival time of grafted NSPCs and determining extent migration away from transplantation sites are essential for optimizing treatment regimens. Here, we used vivo bioluminescence imaging to noninvasively assess residence transplanted at injury living animals, histologic analyses cell integration morphology. Third-generation lentiviral vectors enabled...
The object of this study was to investigate correlations between sagittal spinopelvic alignment and improvements in clinical quality-of-life (QOL) outcomes after lumbar decompression surgery for spinal canal stenosis (LCS) without coronal imbalance.The authors retrospectively reviewed data from consecutive patients treated LCS with the period 2009 through 2011. They examined preoperative or postoperative vertical axis (SVA) radiological parameters, outcomes, health-related (HR)QOL scores...
Study Design. A propensity-matched comparison of risk factors for proximal junctional failure (PJF), which is a symptomatic kyphosis developing after corrective surgery adult spinal deformity (ASD). Objective. To elucidate the role bone strength PJF. Summary Background Data. PJF, devastating complication ASD, often recurs even revision surgery. Most studies PJF are retrospective and have selection bias in surgical strategy, making it difficult to identify modifiable factors. Methods. We...
Abstract To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed. However, these do not always provide consistent antibacterial effects in vivo despite having dramatic vitro, probably because the involve silver-ion-mediated reactive oxygen species generation. Additionally, silver application process often requires extremely high temperatures, which damage non-metal materials. We recently developed a bacteria-resistant...
Abstract We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can contribute to repair injured spinal cord in adult rats and monkeys. In some cases, however, most transplanted adhered cavity wall failed migrate integrate into host cord. this study we focused on chondroitin sulfate proteoglycan (CSPG), a known constituent glial scars is strongly expressed after injury (SCI), as putative inhibitor NSPC migration vivo . hypothesized digestion CSPG by...
Neural progenitor cells (NPC) have been reported to aid in the functional recovery from stroke and hold promise as a novel treatment for variety of neurological diseases. There is need imaging tools study vivo migratory behavior these cells.C17.2 NPC, stably transfected with firefly luciferase, were serially imaged through intact skull skin by bioluminescence over 2 3 weeks nu/nu mice closed-vessel middle cerebral artery infarcts, followed contralateral intraparenchymal or intraventricular...
to reduce intraoperative damage the posterior supporting structures of lumbar spine during decompressive surgery for canal stenosis (LCS), spinous process-splitting laminectomy (LSPSL or split laminectomy) was developed. This prospective, randomized, controlled study conducted clarify whether decreases acute postoperative wound pain compared with conventional laminectomy.forty-one patients LCS were enrolled in this study. The randomly assigned either LSPSL group (22 patients) (19 patients)....
The object of this study was to investigate failures after spinal reconstruction following total en bloc spondylectomy (TES), related factors, and sequelae arising from such in patients with malignant tumors.Fifteen (12 males 3 females, a mean age 46.5 years) tumors who underwent TES survived for more than 1 year were included analysis (mean follow-up 41.5 months). Seven had primary tumors, including giant cell 4 patients, chordoma 2, Ewing sarcoma 1. Eight metastatic thyroid cancer 6 renal...
Retrospective study of registry data.Aging society and recent advances in surgical techniques general anesthesia have increased the demand for spinal surgery elderly patients. Many complications been described patients, but a multicenter perioperative patients aged 80 years or older has not reported. Therefore, goal was to analyze associated with spine cervical, thoracic, lumbar lesions.A performed who underwent 262 surgeries at 35 facilities. The frequency severity were examined...
We studied the frequency, cause, and diagnostic significance of MR findings indicative large amounts hemosiderin in giant-cell tumor bone.The clinical, MR, histologic 16 patients with tumors bone were reviewed. Eight occurred uncommon locations or who not usual age range; other eight more typical. Areas decreased signal intensity considered to be caused by identified. The number distribution RBCs within histologically, presence was determined on sections made iron stains.In 10 cases which...
Delayed transplantation of neural stem/progenitor cells (NS/PCs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. To enhance after NS/PC transplantation, we focused on galectin-1, a carbohydrate-binding protein with pleiotropic roles cell growth, differentiation, apoptosis, neurite outgrowth. Here, to determine combined therapeutic effect galectin-1 injury (SCI), human NS/PCs were transfected by lentivirus green fluorescent (GFP), (Gal-NS/PCs) or GFP...
Retrospective case series.To evaluate our treatment strategy for myxopapillary ependymomas of the cauda equina.Some patients with ependymoma develop cerebrospinal fluid (CSF) dissemination leading to poor prognosis. Because rarity this tumor, there is no consensus on its optimal options and prognosis.We reviewed 25 cases ependymomas, treated surgically between 1972 2005. The mean postoperative follow-up period was 10.4 years. effects surgical margins at surgery radiotherapy tumor recurrence...
This retrospective study was conducted to evaluate the prevalence and clinical consequences of postoperative lamina closure after open-door laminoplasty identify risk factors.Eighty-two consecutive patients with cervical myelopathy who underwent without plates or spacers in open side (Hirabayashi's original method) were included (62 men 20 women a mean age 62 years follow-up 1.8 years). In 67 cause spondylotic myelopathy, 15 it caused by ossification posterior longitudinal ligament....
BACKGROUND: Because an idiopathic spinal extradural arachnoid cyst (SEAC) is rare, its optimal surgical treatment remains controversial. OBJECTIVE: To evaluate the results of treatments for SEACs and to clarify features disease associated with poor outcomes. METHODS: Twelve patients who underwent surgery at our hospital between 1988 2008 were examined retrospectively. The mean follow-up period was 4.7 years. Total resection performed in 7 closure dural defect without 5 patients. Surgical...
Although microendoscopic discectomy (MED) is a minimally invasive surgical method for lumbar disc herniation (LDH), early postoperative recurrence may outweigh that advantage. The purpose of the present study was to retrospectively investigate rate after MED LDH and determine risk factors in patients treated by single surgeon.The included 344 who underwent (213 males 131 females; mean age, 39.3 years; age range, 11-82 follow-up, 3.6 follow-up 2.0-6.5 years). clinical outcomes were evaluated...
Although minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has widely been developed in patients with diseases, surgeons risk exposure to fluoroscopic radiation. However, date, there is no studies quantifying the effective dose during MIS-TLIF procedure, and radiation distribution still unclear. In this study, surgeons' doses at 5 places on bodies were measured assessed 31 consecutive 1- 3-level surgeries. The operating surgeon, assisting radiological technologist wore...