A5063374697- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- Animal health and immunology
- Animal Nutrition and Physiology
- Animal Virus Infections Studies
- Nutritional Studies and Diet
- Immune Cell Function and Interaction
- Osteoarthritis Treatment and Mechanisms
- Tryptophan and brain disorders
- Orthopaedic implants and arthroplasty
- Digestive system and related health
- Virus-based gene therapy research
- Muscle metabolism and nutrition
- Animal Behavior and Welfare Studies
- Microbial Metabolites in Food Biotechnology
- Genetic and phenotypic traits in livestock
Setsunan University
2020-2025
Oita University
2001-2024
Kyoto Prefectural University
2015-2024
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2024
Hirosaki University
2011-2023
Tokyo Metropolitan Agriculture and Forestry Research Center
2019-2023
Kanazawa Hospital
2019-2022
Obayashi (Japan)
2022
The University of Kitakyushu
2022
Saiseikai Kanagawa Hospital
2022
The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. A total of 174 mucus samples from 43 ulcerative colitis (UC), 26 Crohn’s (CD) 14 non-IBD controls were obtained by gentle brushing surfaces cytology brushes. microbiome was analyzed 16S rRNA gene sequencing. There no significant differences structure among different...
The effects of voluntary wheel-running exercise on cecal microbiota and short-chain fatty acid production were investigated in rats. composition was notably different between the exercised sedentary Furthermore, rats showed a significantly higher n-butyrate concentration than This alteration microbial environment may contribute to beneficial effect gastrointestinal disorders.
Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within Firmicutes phylum. A significant decrease of R. colonization in ulcerative colitis patients has recently been demonstrated. In this work, we have investigated mechanisms hominis-host cross talk using both murine and vitro models.The complete genome sequence A2-183 was determined. C3H/HeN germ-free mice were mono-colonized with hominis, host-microbe interaction studied histology,...
Gut microbiota have profound effects on bile acid metabolism by promoting deconjugation, dehydrogenation, and dehydroxylation of primary acids in the distal small intestine colon. High-fat diet-induced dysbiosis gut dysregulation may be involved pathology steatosis patients with non-alcoholic fatty liver disease. Epigallocatechin-3-gallate (EGCG), most abundant polyphenolic catechin green tea, has been widely investigated for its inhibitory or preventive against liver. The aim present study...
Fecal and blood samples of infants with autism spectrum disorders (ASD) healthy were analyzed to investigate the association altered gut microbiota ASD development. 16S rRNA gene-based sequencing found that, unlike those infants, feces had significantly higher lower abundance genera Faecalibacterium Blautia, respectively. Moreover, DNA microarray analysis peripheral mononuclear cells (PBMC) detected more highly than low expressed genes in infants. Gene Ontology revealed that differentially...
We assessed whether gut microbial functional profiles predicted from 16S rRNA metagenomics differed in Japanese type 2 diabetic patients. A total of 22 subjects were recruited our outpatient clinic an observational study. Fecal samples obtained 12 control and 10 subjects. metagenomic data generated using "Phylogenetic Investigation Communities by Reconstruction Unobserved States" software. measured the parameters glucose metabolism, bacterial taxonomy profile, examined associations a...
Proton pump inhibitors (PPIs) are widely used to treat gastro-esophageal reflux and prevent gastric ulcers, have been considered as low risk. However, recent studies identified possible associations between PPI use gut microbiota, suggesting that PPIs increases the risk of enteric infections, including Clostridium difficile infection. To investigate microbiota in Japanese users, we conducted 16S metagenomics analysis fecal samples collected from users healthy adults. In total, 36 non-users...
Abstract Background and Aims Free D-amino acids, which have different functions from L-amino recently been discovered in various tissues. However, studies on the potential interactions between intestinal inflammation acids are limited. We examined inhibitory effects of D-alanine pathogenesis inflammation. Methods investigated serum acid levels 40 patients with ulcerative colitis 34 healthy volunteers. For 7 days [d], acute was induced using dextran sulphate sodium C57BL/6J mice. Plasma were...
Non‐technical summary ACh is the best characterized neurotransmitter that synthesized in cholinergic neurons brain and gut wall. In gut, acetylcholine released from nerve endings response to luminal stimuli regulates movement of contents via stimulating muscle contraction epithelial ion secretion. We show colonic cells on serosal side by chemical stimulation short chain fatty acid propionate causes chloride These results suggest non‐neuronal release plays a role
Sleep disturbances frequently accompany chronic pain from osteoarthritis (OA). Effective management of sleep may require successful treatment pain, a key factor in the clinical evaluation knee OA. However, relationship between severity OA and quality is unclear. Our purpose was to correlate prevalence nocturnal with different levels determine its influence on quality.Subjects included 1,214 local volunteers mean ± SD age 58.1 13.0 years. The existence were determined by Kellgren/Lawrence...
Prebiotic dietary water-soluble fiber obtained from partially hydrolyzed guar gum was added to diets of children with autism spectrum disorders who presented constipation symptoms. Supplementation altered gut microbiota and significantly increased the frequency defecation per week microbiota. In addition, supplementation (p<0.05) decreased tended decrease (p = 0.07) concentrations serum interleukin-1β tumor necrosis factor-α, respectively. More importantly, ameliorated behavioral...
The human gut microbiota is involved in host health and disease development. Therefore, lifestyle-related diseases such as hypertension (HT), hyperlipidemia (HL), type 2 diabetes mellitus (T2D) may alter the composition of microbiota. Here, we investigated changes related to these their coexistence. This study 239 Japanese subjects, including healthy controls (HC). fecal was analyzed through isolation bacterial genomic DNA obtained from samples. Although there were no significant differences...
Functional dyspepsia (FD) is associated with poor health-related quality of life. Recent evidence suggests that the main pathogenesis suspect gut mucosa-associated microbiota (MAM). However, little known about MAM in FD subjects. The aim this study was to clarify relationship between upper gastrointestinal symptoms and characteristics MAM.Five mucosa samples from (intraoral, mid-esophagus, gastric body, antrum, descending portion duodenum) were collected a brush under endoscopic examination...
Partially hydrolyzed guar gum (PHGG) is a water-soluble dietary fiber and used in solid liquid food to regulate gut function. The aim of this study was investigate effects PHGG on bowel movements (stool form frequency), plasma bile acids, quality life, microbiota healthy volunteers with tendency toward diarrhea, i.e., irritable syndrome diarrhea (IBS-D)-like symptoms. A randomized, double-blind, placebo-controlled, parallel trial performed 44 (22 males, 22 females, 41.9 ± 6.3 years old...
Gut dysbiosis is generally associated with type 2 diabetes mellitus. However, the effect of habitual dietary intake on gut in Japanese patients mellitus has not yet been explicated. This study investigated whether alteration microbiota was influenced by sucrose mellitus.In this cross-sectional study, 97 and healthy individuals were matched age sex, then, fecal samples obtained. Next-generation sequencing 16S ribosomal ribonucleic acid gene carried out, functional profiles for analyzed. We...
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that pathogenesis of loss may involve dysbiosis gut microbiota accompanying chronic inflammation or altered metabolism. In this study, we evaluated possible effects modifying microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related its mechanism using colon-26...
The intestinal commensal microbiota of monogastricanimals such as humans and pigs comprise hundredsof different types microorganisms (Conway, 1995;Savage, 1977). In the last several decades, role ofthe in a wide range ofhost’s physiological functions has been increasinglyrecognized (Cummings Macfarlane, 1997). Colo-nization by develops thefunctions intestine, evidenced mal-devel-opment germ-free animals(Hooper et al., 2001; Wostmann 1983) whichwere made artificially so that they were free...