A5061869584- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory mediators and NSAID effects
- Gastrointestinal Tumor Research and Treatment
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Congenital Heart Disease Studies
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Vitamin C and Antioxidants Research
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
Kyoto Prefectural University of Medicine
2016-2025
Shizuoka Medical Center
2014-2025
National Hospital Organization
2014-2025
Shimizu (Japan)
2014-2023
The Japanese Society of Gastroenterological Surgery
2021-2023
Institute of Nutrition and Pathology (Japan)
2023
Nagoya Medical Center
2021-2023
National Institute of Diabetes and Digestive and Kidney Diseases
2018-2023
ProQuest (United States)
2018-2023
Gifu University of Medical Science
2023
The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. A total of 174 mucus samples from 43 ulcerative colitis (UC), 26 Crohn’s (CD) 14 non-IBD controls were obtained by gentle brushing surfaces cytology brushes. microbiome was analyzed 16S rRNA gene sequencing. There no significant differences structure among different...
Several epidemiological studies have shown that regular exercise can prevent the onset of colon cancer, although underlying mechanism is unclear. Myokines are secreted skeletal muscle proteins responsible for some exercise-induced health benefits including metabolic improvement and anti-inflammatory effects in organs. The purpose this study was to identify new myokines contribute prevention tumorigenesis.To novel muscle-derived proteins, DNA microarrays were used compare transcriptome tissue...
NK cells can destroy tumor without prior sensitization or immunization. Tumors often lose expression of MHC molecules and/or antigens. However, lyse in a non-MHC-restricted manner and independent the tumor-associated are therefore considered ideal for adoptive cancer immunotherapy; however difficulty obtaining large numbers fully functional that safe to administer deters its clinical use. This phase I trial seeks address this obstacle by first developing novel system expands highly activated...
Abstract Background Species-level genetic characterization of complex bacterial communities has important clinical applications in both diagnosis and treatment. Amplicon sequencing the 16S ribosomal RNA (rRNA) gene proven to be a powerful strategy for taxonomic classification bacteria. This study aims improve method full-length rRNA analysis using nanopore long-read sequencer MinION™. We compared it conventional short-read mock community human fecal samples. Results modified our existing...
The efficacy of azathioprine for Crohn's disease under adalimumab treatment remains obscure.In an open-labelled prospective study, we evaluated the with and without in patients active disease, who were naïve to biologics thiopurines. randomly assigned subcutaneous administration [monotherapy group] or exactly same schedule [25-100mg daily] [combination 52 Weeks. primary endpoint was clinical remission at WWeek 26. We also score simple endoscopic severity before therapy WWeeks 26 52.A total...
Abstract Background The stability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on human skin remains unknown, considering hazards viral exposure to humans. We generated a model that allows safe reproduction clinical studies application pathogens and elucidated SARS-CoV-2 skin. Methods evaluated influenza A virus (IAV), mixed with culture medium or upper mucus, surfaces dermal disinfection effectiveness 80% (weight/weight) ethanol against IAV. Results IAV were...
Managing irritable bowel syndrome (IBS) has attracted international attention because single-agent therapy rarely relieves bothersome symptoms for all patients. The Japanese Society of Gastroenterology (JSGE) published the first edition evidence-based clinical practice guidelines IBS in 2015. Much more evidence accumulated since then, and new pharmacological agents non-pharmacological methods have been developed. Here, we report second JSGE-IBS comprising 41 questions including 12 background...
The roles of active oxygen, lipid peroxidation, and the antioxidative defence mechanism in gastric mucosal injury induced by treatment with indomethacin rats were investigated. total area erosions concentration peroxides mucosa increased time after administration (20 mg/kg, orally). alpha-tocopherol:total cholesterol ratio serum was significantly decreased activity glutathione peroxidase, an important enzyme to scavenger peroxides, inhibited indomethacin. Treatments superoxide dismutase...
The primary graft-related complication during the first clinical trial evaluating use of tissue-engineered vascular grafts (TEVGs) was stenosis. We investigated role macrophages in formation TEVG stenosis a murine model. analyzed natural history macrophage infiltration at critical time points and evaluated cell seeding on neovessel formation. To assess function infiltrating macrophages, we implanted TEVGs into mice that had been depleted using clodronate liposomes. confirm this, used...
Oxidative stress is implicated as an important mechanism by which diabetes causes nephropathy. Astaxanthin, found a common pigment in algae, fish, and birds, carotenoid with significant potential for antioxidative activity. In this study, we examined whether chronic administration of astaxanthin could prevent the progression diabetic nephropathy induced oxidative mice. We used female db/db mice, rodent model type 2 diabetes, their non-diabetic db/m littermates. The mice were divided into...
Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic beta-cells and various forms tissue damage in patients with diabetes mellitus. Astaxanthin, a carotenoid marine microalgae, is reported as strong anti-oxidant inhibiting lipid peroxidation scavenging reactive oxygen species. The aim present study was to examine whether astaxanthin can elicit beneficial effects on progressive destruction db/db mice--a well-known obese model type 2 diabetes. We used...
MicroRNAs (miRNAs) are small noncoding RNAs involved in posttranscriptional gene regulation that have been shown to be growth, development, function, and stress responses of various organs. The purpose this study was identify the miRNA response physical activity, which related functions such as nutrient metabolism, although miRNAs currently unknown. C57BL/6 mice were divided into exercise control groups. group performed running exercise, with a gradual increase load over 4 wk. On other hand,...