A5113427115- Esophageal Cancer Research and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Metal complexes synthesis and properties
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Cancer Cells and Metastasis
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Nosocomial Infections in ICU
- Vascular Malformations and Hemangiomas
- Central Venous Catheters and Hemodialysis
- Muscle Physiology and Disorders
- Cancer-related Molecular Pathways
- Acupuncture Treatment Research Studies
- Clostridium difficile and Clostridium perfringens research
- Pancreatic and Hepatic Oncology Research
- Exercise and Physiological Responses
- Cancer Diagnosis and Treatment
- Enzyme function and inhibition
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
Japanese Red Cross Society Kyoto Daini Hospital
2024-2025
Kyoto City Hospital
2023
Kyoto Prefectural University of Medicine
2018-2022
Japanese Red Cross Nagoya Daiichi Hospital
2015
Kyoto first Red Cross hospital
2015
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that pathogenesis of loss may involve dysbiosis gut microbiota accompanying chronic inflammation or altered metabolism. In this study, we evaluated possible effects modifying microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related its mechanism using colon-26...
Background: Vacuolar ATPase (V-ATPase) is involved in cancer development. The use of proton pump inhibitors (PPIs) as V-ATPase has been reported to enhance the effectiveness chemotherapy certain cancers. This study aimed evaluate effect PPIs on for esophageal cancer. Methods: To investigate effects cells, human KYSE50 and 70 cells were plated 3 (lansoprazole, esomeprazole, vonoprazan) added at various concentrations with 5-Fluorouracil (5-FU) corresponding a cell viability assay. PPI...
A 66-year-old man was admitted to our hospital with high fever. We diagnosed a gas-containing liver abscess and performed percutaneous drainage. However, 15 hours after admission, he developed massive intravascular hemolysis acidosis. Sepsis due Clostridium perfringens suspected we treated the patient intensively multidisciplinary approaches, including antibiotics, mechanical ventilation, renal replacement therapy. Furthermore, administered freeze-dried gas gangrene antitoxin. Despite...
Primary neuroendocrine carcinoma (NEC) of the anal canal is a rare, highly malignant tumor with poor prognosis. Despite standard first-line treatment etoposide or irinotecan combined cisplatin, effective second-line therapies are lacking. In 2019, Japan approved cancer genome profiling (CGP) tests for solid tumors to enhance genomic understanding. We present case 79-year-old woman NEC canal, treated etoposide, carboplatin, and amrubicin. Post-standard therapy, CGP suggested pemigatinib,...
Abstract Introduction: V-ATPase is highly expressed in cancer cells and has been shown to be involved the transformation of normal into cells, invasion tissues, survival formation drug resistance. The use proton pump inhibitors (PPIs) as enhance efficacy chemotherapy some cancers. Material Method: We investigated effect on esophageal squamous cell carcinoma, one major causes mortality Japan. First, three PPIs at various concentrations (lansoprazole, esomeprazole, bonoprazan) pyrimidine...
Abstract Background: Immune checkpoint molecules such as PDL1 and CD155 are expressed on cancer cells regulate tumor immunity by binding to ligands immune cells. Although soluble forms of have been detected in the blood, roles these not fully elucidated. In this study, clinical significance advanced esophageal was examined. Methods: Soluble (sPDL1), PD1(sPD1), CD155(sCD155), LAG3 (sLAG3) were measured ELISA 47 patients who diagnosed with planned receive multidisciplinary treatment our...
Abstract Background: Epithelial-mesenchymal transition (EMT) is considered to be a crucial event in the development of cancer metastasis. Metformin an antidiabetic drug used treatment type 2 diabetes. Recently, increasing evidence has indicated that metformin can inhibit tumor growth, however, effect on EMT remains still well unknown. Methods: We investigated whether inhibits human pancreatic cell lines (PANC-1, BXPC-3, and MIAPaCa-2). Pancreatic cells were stimulated TGF-β1 (10ng/ml) with...
Background: Epithelial-mesenchymal transition (EMT) is considered to be a crucial event in the development of cancer metastasis. Metformin an antidiabetic drug used treatment type 2 diabetes. Recently, increasing evidence has indicated that metformin can inhibit tumor growth, however, effect on EMT remains still well unknown.Methods: We investigated whether inhibits human pancreatic cell lines (PANC-1, BXPC-3, and MIAPaCa-2). Pancreatic cells were stimulated TGF-β1 (10ng/ml) with or without...