Atsushi Ono
A5053275355- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Liver Disease and Transplantation
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Renal Diseases and Glomerulopathies
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- MRI in cancer diagnosis
- Marine and fisheries research
- Gastric Cancer Management and Outcomes
- Spinal Dysraphism and Malformations
- Systemic Lupus Erythematosus Research
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
Life Science Institute
2014-2025
Hiroshima University
2016-2025
Kawasaki University of Medical Welfare
2018-2024
Hiroshima University Hospital
2019-2024
Hiroshima City Asa Citizens Hospital
2024
Fukushima Medical University
2013-2023
Kumamoto University
2023
Tokyo Metropolitan Agriculture and Forestry Research Center
2023
Wakayama Medical University
2021-2023
Edogawa Hospital
2023
Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the HCC decreased but not eliminated after a sustained virologic response (SVR) to direct-acting (DAA) agents, and higher in patients with advanced fibrosis. We investigated HCV-induced epigenetic alterations that might affect DAA treatment mice humanized livers.We performed genome-wide ChIPmentation-based ChIP-Seq RNA-seq analyses of liver tissues...
Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory chemopreventive approaches absent. Chronic C (CHC) results in epigenetic alterations driving risk persisting following cure. Here, we aimed to investigate modifications targets liver cancer chemoprevention.Liver tissues from patients NASH CHC were analysed by ChIP-Seq...
The tumor microenvironment can be classified into immunologically active "inflamed" tumors and inactive "non-inflamed" based on the infiltration of cytotoxic immune cells. Previous studies liver cancer have reported a superior prognosis for inflamed compared to non-inflamed tumors. However, is highly heterogeneous genetically, finer classification may improve our understanding its immunological diversity response therapy.We characterized gene signatures 234 primary cancers, mainly...
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts 409 NAFLD from multiple global regions, we defined and validated hepatic transcriptome serum secretome signatures predictive long-term HCC NAFLD. A 133-gene signature, prognostic signature (PLS)–NAFLD, predicted incident over up to 15 years longitudinal observation. High-risk PLS-NAFLD was associated IDO1 + dendritic cells dysfunctional CD8 T...
<h3>Importance</h3> The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. <h3>Objective</h3> To determine whether early surgical decompression results in better motor recovery than delayed treatment patients with incomplete SCI associated preexisting canal stenosis but without bone injury. <h3>Design, Setting, and Participants</h3> This multicenter randomized clinical trial was conducted 43 tertiary referral centers Japan from December 2011 through November...
To compare the tumor control and safety of stereotactic body radiation therapy (SBRT) combined with transcatheter arterial chemoembolization (TACE) for small, solitary, hypervascular hepatocellular carcinoma (HCC) TACE alone.Three hundred sixty-five HCC patients who had ≤ 3 cm, nodule were treated TACE. Among them, 30 followed by SBRT (SBRT group) 38 without additional previous treatment (control enrolled in this retrospective cohort study. Local progression, complication, disease-free...
Circulating tumor DNA (ctDNA) carrying tumor-specific sequence alterations has been found in the cell-free fraction of blood. Liver cancer specimens are difficult to obtain, and noninvasive methods required assess progression characterize underlying genomic features.We analyzed 46 patients with hepatocellular carcinoma who underwent hepatectomy or liver transplantation for whom whole-genome sequencing data was available. We designed personalized assays targeting somatic rearrangements each...
Background and aims HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC remains elevated. perturbs host cell signalling to maintain infection, derailed circuitry key driver carcinogenesis. Since protein phosphatases are regulators events, we aimed identify that respond with relevance for hepatocarcinogenesis. Methods We assessed mRNA microRNA (miRNA) expression profiles in primary human hepatocytes, liver biopsies resections...
A prospective study in 19 patients after cervical laminoplasty, using magnetic resonance imaging.To evaluate the value of spinal cord shift at 24 hours laminoplasty.Postoperative C5 palsy is a noticeable complication within 1 week laminoplasty. The root tethering due to posterior laminoplasty was reported as one causes palsy. However, surgery unknown.The measured consecutive on images and 2 weeks laminoplasty.The mean 2.8 mm, with maximum level, decreasing 1.9 mm weeks. correlated amount...
Retrospective multi-institutional study.To investigate the incidence of neurological deficits after cervical laminoplasty for ossification posterior longitudinal ligament (OPLL).According to analysis long-term results, OPLL has been reported as a safe and effective alternative procedure with few complications. However, perioperative complication rates have not well described.Subjects comprised 581 patients (458 men 123 women; mean age: 62 ± 10 years; range: 30-86 years) who had undergone at...
We assessed the risk factors for development of hepatocellular carcinoma (HCC) following successful eradication hepatitis C virus (HCV) with interferon (IFN) therapy in a long-term, large-scale cohort study.We reviewed 1094 consecutive patients HCV who achieved sustained virological response (SVR) IFN between January 1995 and September 2013.During observation period (median 50 months: range 13-224), 36 (3%) developed HCC after SVR. The median from SVR to diagnosis was 37 months (range...
Radiographic findings may provide clues to the underlying cause of neck symptoms. However, these associations remain controversial. This study investigates association between roentgenographic cervical spine and symptoms in a Japanese community population.A total 762 volunteers participated this study. Sagittal radiographs were taken questionnaire about presence visual analog scale (VAS) for pain or stiff shoulder was completed. The sagittal alignment (C2-C7) degenerative index measured from...
The risk of hepatocellular carcinoma (HCC) development is reduced following viral elimination by interferon therapy in chronic hepatitis C patients. However, the patients treated with interferon-free direct-acting antivirals (DAAs) unknown. We evaluated who achieved eradication pegylated-interferon plus ribavirin (PEG-IFN/RBV, n = 244) or daclatasvir asunaprevir (DCV/ASV, 154) therapy. None had prior history HCC antiviral median observation period after end treatment for PEG-IFN/RBV and...
OBJECTIVES: Biomarkers for optimizing the outcome of treatment with lenvatinib in patients advanced hepatocellular carcinoma remain to be established despite intensive and comprehensive genomic research. Lenvatinib is characterized by its prominent inhibitory potency fibroblast growth factor receptor (FGFR) 4 compared earlier tyrosine kinase inhibitors. Thus, this study, we focused on simplified quantification FGFR4 tumors as a potential predictive indicator. METHODS: According The Cancer...
Abstract Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused Hepatitis B virus, which DNA molecules from virus inserted into genome causing dramatic changes its configuration, including non-homologous chromosomal fusions, dicentric chromosomes...
The aim of this study was to investigate the early tumor response and safety atezolizumab plus bevacizumab for patients with unresectable hepatocellular carcinoma in real-world practice. Forty Child-Pugh class A liver function eastern cooperative oncology group performance status 0 or 1 were enrolled. objective rate (ORR) at six weeks after start treatment, changes α-fetoprotein (AFP) des-γ-carboxyprothrombin, incidence adverse events (AEs), albumin-bilirubin (ALBI) score serum ammonia...
Abstract Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple robust human cell-based system modeling clinical prognostic signature (PLS) predicting long-term progression toward HCC. Using the PLS as readout, followed by validation in nonalcoholic steatohepatitis/fibrosis/HCC animal patient-derived spheroids,...
Genes generate transcripts of various functions by alternative splicing. However, in most transcriptome studies, short-reads sequencing technologies (next-generation sequencers) have been used, leaving full-length unobserved directly. Although long-reads would enable the transcripts, data analysis is difficult. In this study, we developed an pipeline named SPLICE and analyzed cDNA sequences from 42 pairs hepatocellular carcinoma (HCC) matched non-cancerous livers with Oxford Nanopore...