A5067937456- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Psoriasis: Treatment and Pathogenesis
- Urinary and Genital Oncology Studies
- Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Multiple and Secondary Primary Cancers
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Bone health and treatments
- CAR-T cell therapy research
Servicio Gallego de Salud
2016-2024
Universidade de Santiago de Compostela
2021-2024
Centro de Investigación Biomédica en Red de Cáncer
2018-2024
Instituto de Investigación Sanitaria de Santiago
2016-2024
Instituto de Salud Carlos III
2022-2024
Center for Research in Molecular Medicine and Chronic Diseases
2023
University of Oslo
2023
Complejo Hospitalario Universitario de Santiago
2016-2023
Rambam Health Care Campus
2023
Complexo Hospitalario Universitario A Coruña
2016-2020
Abstract Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused Hepatitis B virus, which DNA molecules from virus inserted into genome causing dramatic changes its configuration, including non-homologous chromosomal fusions, dicentric chromosomes...
Radium-223 dichloride (Ra-223) is recommended as a treatment option for metastatic castration-resistant prostate cancer (mCRPC) patients with symptomatic bone metastases and no visceral disease, after docetaxel failure, or in who are not candidates to receive it. In this study, we aimed ambispectively analyze overall survival (OS) prognostic features mCRPC receiving Ra-223 per clinical routine practice identify the most suitable sequence.
Few studies have investigated the safety and efficacy of anti-PD-(L)1 antibodies in metastatic urothelial carcinoma (mUC) daily clinical practice. Knowledge about influence baseline analytical factors on therapy outcomes is scarce.
The lung immune prognostic index (LIPI) has been proposed as a new categorical blood-based biomarker to select advanced non-small cell cancer (NSCLC) patients for anti-programmed death-1 (PD-1) or programmed death ligand 1 (PD-L1) therapy. In this study, we investigate the first time best of our knowledge and predictive utility LIPI in multicenter nivolumab monotherapy-based cohort. We retrospectively analyzed influence baseline on overall survival (OS), progression-free (PFS), disease...
Abstract The analysis of mismatch repair proteins in solid tissue is the standard care (SoC) for microsatellite instability (MSI) characterization endometrial cancer (EC). Uterine aspirates (UAs) or circulating‐DNA (cfDNA) samples capture intratumor heterogeneity and provide a more comprehensive dynamic molecular diagnosis. Thus, MSI by droplet‐digital PCR (ddPCR) UAs cfDNA can reliable tool to characterize follow‐up disease. UAs, paraffin‐embedded tumor (FFPE) longitudinal plasma from...
Abstract Background Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated clinical utility promoter methylation long noncoding RNA LINC00473 as a biomarker to detect cancer and associated precancerous lesions. Methods epigenetic regulation through hypermethylation cell lines using bisulfite genomic sequencing expression analyses. DNA was analyzed primary tumors 450K arrays RNA-seq from The Cancer Genome Atlas (TCGA). Tissue-based findings were...
Abstract Pan-Immune-Inflammation Value (PIV) has been recently proposed as a new blood-based prognostic biomarker in metastatic colorectal cancer (mCRC). Herein we aimed to validate its significance and evaluate utility for disease monitoring patients with mCRC receiving first-line chemotherapy. We conducted single-centre retrospective study involving 130 previously untreated under standard chemotherapy real-world scenario. PIV was calculated (neutrophil count × platelet monocyte...
In the advanced renal cell carcinoma (RCC) scenario, there are no consistent biomarkers to predict clinical benefit patients derived from immune checkpoint blockade (ICB). Taking this into consideration, herein, we conducted a retrospective study in order develop and validate gene expression score for predicting anti-PD-1 antibody nivolumab context of diagnosed with clear RCC enrolled CheckMate-009, CheckMate-010, CheckMate-025 trials. First, three-gene (3GES) prognostic value overall...
The safety and efficacy of nivolumab in treating advanced renal cell carcinoma (aRCC) patients have been evaluated real-world evidence (RWE) studies across various European countries, but no such data from Spain reported until now. We conducted a multicenter, retrospective study on 222 previously treated aRCC to assess the impact pre-treatment factors therapy outcomes clinical practice scenario Spain. Our results were then compared with other significant experiences involving monotherapy....
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on risk metachronous cancer (CRC) in patients with Lynch syndrome, analyzing data from Prospective Syndrome Database version 5. Extended resection significantly reduced CRC path_MLH1, path_MSH2, and path_MSH6 carriers compared to resection.