A5080843181- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Scoliosis diagnosis and treatment
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Cervical and Thoracic Myelopathy
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Tuberculosis
- Spinal Hematomas and Complications
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Bone health and osteoporosis research
- Musculoskeletal synovial abnormalities and treatments
- Spondyloarthritis Studies and Treatments
- Bone Metabolism and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Pregnancy-related medical research
- Connective tissue disorders research
- Bone and Joint Diseases
- Spinal Dysraphism and Malformations
Toho University Medical Center Sakura Hospital
2016-2025
Toho University
2016-2025
Toho University Omori Medical Center
2021
Teikyo University Chiba Medical Center
2021
Chiba University
2002-2021
University of Tsukuba
2020-2021
Chiba Prefectural Sawara High School
2021
University of Toyama
2019
Tokyo Women's Medical University Adachi Medical Center
2019
Okayama University
2019
Abstract Recent reports have demonstrated that intermittent treatment with parathyroid hormone (1–34) [PTH(1–34)] increases callus formation and mechanical strength in experimental fracture healing. However, little is known about the optimal dose required for enhancement of repair or molecular mechanisms by which PTH regulates healing process. In this study, we analyzed underlying affects tested hypothesis low-dose human PTH(1–34) can increase strength. Unilateral femoral fractures were...
The importance of pelvic incidence-lumbar lordosis (PI-LL: PI minus LL) mismatch is emphasized in long-segment fusion for adult spinal deformity; however, there are few studies evaluating the influence PI-LL on surgical outcomes after short-segment fusion. In this study, we have examined effects lumbar intervertebral degenerative diseases. Patients with disease treated by (1 or 2 levels) transforaminal interbody were divided into Group A (PI-LL ≤ 10°: n = 22) and B ≥ 11°: 30). Pre-and...
To comprehensively evaluate gene expression in the early stage of fracture healing, we used a cDNA microarray with 2304 clones derived from an oligo-capped mouse embryo library. Closed mid-diaphyseal fractures were created tibiae and profiles analyzed 3 days after fracture. Six genes up-regulated comparison to those unfractured bones these included three previously identified but never shown be present fractures, periostin, calumenin, FHL-1. Cloning has been completed their pattern function...
Because the authors encountered 4 cases of hardware migration following transforaminal lumbar interbody fusion, a retrospective study was conducted to identify factors influencing posterior fusion cages.Patients with degenerative disc disease (125 individuals; 144 levels) were treated using and followed for 12-33 months. Medical records pre- postoperative radiographs reviewed, incidence cage analyzed.Postoperative found in patients at or before 3 all cages that migrated postoperatively...
Object Many surgeons currently prefer to use transforaminal lumbar interbody fusion (TLIF), placing 1 unilateral pedicle screw (PS) and cage. However, no study has examined whether fixation improves surgical outcome. The authors conducted a prospective randomized controlled trial with minimum 2-year follow-up analyze TLIF outcomes for 2 techniques: placement of PS cage compared bilateral PSs cages. Methods Fifty patients degenerative spondylolisthesis undergoing single-level were randomly...
Abstract Lumbar spondylolysis generally occurs in adolescent athletes. Bony union can be expected with conservative treatment, however, the fracture does not heal some cases. When becomes a pseudoarthrosis, patients have potential to develop isthmic spondylolisthesis. A cross-sectional study was performed determine incidence of and spondylolisthesis, elucidate when how often spondylolisthesis or without spondylolysis. Patients undergoing computed tomography (CT) scans abdominal lumbar...
Because we have a clinical impression that elderly patients low back pain while in motion and standing, but less when sitting, investigate characteristics of nonspecific (NSLBP), using new detailed visual analog scale (VAS) scoring system. One hundred eighty-nine with NSLBP were divided into an group (≥65 years old, n = 56) young (<65 133). Low was evaluated by traditional VAS system, the Oswestry Disability Index (ODI), system which is independently three different postural situations (in...
Nerve growth factor (NGF) has an important role in the generation of discogenic pain. We hypothesized that annular rupture is a trigger for pain through action NGF. In this study, protein levels NGF discs from patients with disc herniation were examined and compared those other lumbar degenerative diseases.Patients (n = 55) disease treated by surgery included. Nucleus pulposus tissue (or herniated tissue) was surgically removed homogenized; quantified using enzyme-linked immunosorbent assay...
A kinematically aligned (KA) total knee arthroplasty (TKA) is expected to improve patient satisfaction, but its effect remains controversial. We investigated differences in patient-reported outcomes (PROs) between KA and non-KA TKAs using an implant that reproduces anatomical geometry. for varus deformity were performed consecutive 129 patients (149 knees) via a measured resection technique with conventional instruments. The femorotibial angle (FTA), hip-knee-ankle (HKAA), the joint line...
Objectives. Reactive oxygen species (ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive metabolites (ROM) patients RA using a new Free Radical Analytical System and determined clinical parameters associated ROM. Methods. One hundred fifty-two 80 diabetes mellitus (DM) were included observational study. To measure ROM, d-ROM test was performed on...
Abstract Background Several authors have reported favorable results in low back pain (LBP) for patients with lumbar disc herniation (LDH) treated discectomy. However, detailed changes over time the characteristics and location of LBP before after discectomy LDH remain unclear. To clarify these points, we conducted an observational study to determine LDH, using a visual analog scale (VAS) bilaterally. Methods We included 65 by this study. A VAS was administered patient under 3 different...
Abstract Cbl proteins are multifunctional adaptor molecules that modulate cellular activity by targeting the ubiquitylating system, endocytic complexes, and other effectors to a wide variety of regulatory proteins, especially activated receptor nonreceptor tyrosine kinases. Cbl-b perform unique functions in various cells, addition redundant required for embryonic development. We previously showed eliminating impaired osteoclast motility, which modestly delayed bone now report Cbl-b−/− mice...
Unilateral laminectomy for bilateral decompression (ULBD) lumbar spinal stenosis (LSS) is a less invasive technique compared to conventional laminectomy. Recently, several authors have reported favorable results of low back pain (LBP) in patients LSS treated with ULBD. However, the detailed changes and localization LBP before after ULBD remain unclear. Furthermore, unsymmetrical invasion para-spinal muscle facet joint may result residual symptoms. To clarify these points, we conducted an...
Orthostatic hypotension is frequently observed in patients with neurodegenerative diseases such as multiple system atrophy (MSA) and Parkinson’s disease (PD). This study aimed to investigate the immediate effects of ankle plantar-dorsal flexion (APDF) exercises on hemodynamics autonomic nerve function orthostatic hypotension. Thirteen consecutively admitted diagnosed MSA or PD were included this study. crossover two consecutive, randomly assigned intervention sessions: one exercise session...
Magnetic resonance imaging around metal joint prostheses including multiacquisition variable-resonance image combination selective at 1.5 T (from April 2014 to August 2020) was retrospectively evaluated by 2 radiologists for detection of abnormal findings (joint effusion, capsular thickening, pericapsular edema, soft-tissue fluid collection, bone marrow edema pattern the implant [BME pattern], lymphadenopathy, and others) overall impression PJI. Regarding presence communication or...
Abstract The goal of this study was to investigate the impact postoperative inclination joint line on clinical results after total knee arthroplasty (TKA) using a prosthesis with anatomical geometry. This included 145 primary cruciate-retaining type Three years postoperatively, outcomes including patient-reported (PROs) were recorded. Limb alignment evaluated by hip-knee-ankle (HKA) axis and assessed orientation angle (JLOA). Knees divided into two groups according HKA: in-range (− 3 3°)...
Running exercise is an effective therapy for the prevention of osteoporosis; however, appropriate duration has not been determined. We therefore investigated effect on bone mineral density (BMD) and systemic metabolism using young growing rats. Fifteen 8-week-old female Wistar rats were divided into three groups according to running load: control group (no running), short (30 min/day) long (180 min/day), animals ran a treadmill 5 days per week over 8-week period. BMD tibia was measured...
Because the sciatic nerve leaves pelvis through greater notch underneath piriformis muscle, any pathology of muscle could result in entrapment nerve; this is widely known as syndrome. Pyomyositis may be a cause Piriformis syndrome caused by pyomyositis pediatric patients rare. This article describes case sciatica patient. A 6-year-old boy presented with right buttock and thigh pain following mild fever sore throat. The worsened, he became unable to walk. On admission, his temperature was...