A5103039279- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Spine and Intervertebral Disc Pathology
- Myofascial pain diagnosis and treatment
- Infrared Thermography in Medicine
- Botulinum Toxin and Related Neurological Disorders
- Anesthesia and Pain Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Pregnancy-related medical research
- Advanced X-ray and CT Imaging
- Shoulder Injury and Treatment
- Radiation Dose and Imaging
- Neuropeptides and Animal Physiology
- Transcranial Magnetic Stimulation Studies
- Healthcare and Venom Research
- Mechanics and Biomechanics Studies
- Scoliosis diagnosis and treatment
- Forensic Anthropology and Bioarchaeology Studies
- Medical Imaging Techniques and Applications
- Plant Toxicity and Pharmacological Properties
- Neuroscience and Neuropharmacology Research
- Nerve Injury and Rehabilitation
- Microbial Natural Products and Biosynthesis
Hiroshima University
2020-2022
Sanno Medical Center
2015-2018
Shinshu University
1975-2016
Saitama Red Cross Hospital
2014
Chiba Hospital
2013
Chiba University
2000-2010
Tobu Ryoiku Center
2002-2008
Secom (Japan)
2003
Johns Hopkins Medicine
1998
Johns Hopkins University
1998
Study Design. The vertebral levels of dorsal root ganglia innervating the portion L5–L6 intervertebral disc were investigated in rats using a retrograde transport method. pathways and functions nerve fibers supplying determined by denervation immunohistochemistry. Objectives. lumbar has been reported to be innervated segmentally, but anesthetic block paravertebral sympathetic trunks L2 spinal can relieve discogenic low back pain. In current study, sensory innervation was investigated,...
Dermatomes of rats from C1 to T1 (forelimb) and T12 S2 (hindlimb) were determined by electrical stimulation spinal nerves following the intravenous administration Evans blue. After ventral ramus a nerve, blue spotted area presenting maximal innervation nerve appeared in skin. Maximal areas generally overlapped adjacent areas. Each digit was innervated two three nerves. Composite dermatomes where boundary lines defined as midline overlapping Based on composite dermatomes, rat fore- hindlimbs...
Study Design The authors studied the origin of nerves supplying posterior portion lumbar intervertebral discs in rats by resection sympathetic trunks. Objective To understand discogenic low back pain from innervation discs. Summary Background Data afferent pathways have not been thoroughly. It has reported that stimulation an inflamed lower spinal nerve root elicits leg but and evokes only pain. These facts suggest sensation is transmitted via roots. Methods Forty-five Wistar were used....
The afferent pathways of discogenic low-back pain have not been fully investigated. We hypothesised that this was transmitted mainly by sympathetic fibres in the L2 nerve root, and 33 patients we used selective local anaesthesia nerve. Low-back disappeared or significantly decreased all after injection. Needle insertion provoked which radiated to low back 23 area skin hypoalgesia produced included pre-existing but one. None nine with related sciatica had relief component their symptoms. Our...
The levels of dorsal root ganglia and paravertebral sympathetic innervating the lumbar facet joint were investigated in rats using retrograde transport method. pathways functions nerve fibers supplying determined immunohistochemically.To study pain relation to its innervation.The joints have been reported be innervated segmentally. Little is known, however, about origins fibers.Cholera toxin B subunit, a neural tracer, was placed L5-L6 joint, bilateral examined immunohistochemically. serial...
We used anatomic tracers and immunoreactivity in rats to define dorsal root ganglion neuron populations innervating the lumbar discs physiologic inflammatory states.To investigate percentages of calcitonin gene-related peptide-immunoreactive (CGRP-ir) isolectin B4 (IB4)-binding neurons discs.Small are classified into two types. One contains CGRP expresses nerve growth factor receptor. The other binds IB4 glial cell line-derived neurotrophic receptor.A neurotracer, Fluoro-Gold, was applied...
Study Design The level of dorsal root ganglia that receives sensory afferent nerves from the anterior portion lower lumbar intervertebral disc was investigated in rats using a retrograde transport method. Objectives Sometimes patients with lesions complain inguinal pain does not correspond to dermatome injured nerve roots. To investigate origin pain, authors studied innervation disc. Summary Background Data posterior has been extensively and reported be segmental. However, little is known...
Abstract Dermatomes and the associated central projection fields were studied with application of fluorescent neurotracer, 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate (DiI), to 21 reference points on rat trunk hindlimb skin. Segmental distribution rostrocaudal level dorsal root ganglion (DRG) neurons innervating examined DiI‐induced areas mapped in horizontal plane through lamina II horn. levels DRG generally identical determined using dye‐extravasation methods....
It has been thought that lumbar intervertebral discs were innervated segmentally. We have previously shown the L5-L6 disc in rat is bilaterally from L1 and L2 dorsal root ganglia through paravertebral sympathetic trunks, but pathways between trunks unknown. now studied spines of 17 rats to elucidate exact pathways. examined serial sections spine using immunohistochemistry for calcitonin gene-related peptide, a sensory nerve marker. showed these fibres ran sinuvertebral into rami...
The segmental levels of dorsal root ganglions innervating the sacroiliac joint in rats were investigated using retrograde transport method. pathways and functions nerve fibers supplying determined by immunohistochemical detection transported tracer.To study sensory innervation to elucidate neural low back pain originating from joint.The is a possible source pain. L4-S4 spinal nerves have been regarded as humans. However, origins not analyzed experimentally with tracer methods.Cholera toxin B...
Abstract The purpose of this study is to clarify sensory innervation in the ventral and dorsal sides sacroiliac joint. Fluoro‐gold, a neural tracer, was injected into left joint adult rats from side after denervation side, bilateral root ganglia (DRGs) T13 S4 were examined by fluorescence microscopy five days injection. In another rat group, DRGs using same methods injection fluoro‐gold side. case (ventral nerve supply), labeled neurons mainly located ipsilateral L1 S2. On other hand,...
We evaluated 2 types of nerve growth factor (NGF) receptors on dorsal root ganglion (DRG) cells and fibers innervating rat lumbar intervertebral discs.To examine the NGF receptors, tyrosine kinase A (TrkA) p75 neurotrophin receptor (p75NTR) DRG discs using immunohistochemistry a retrograde neurotracing method.Nerve innervation is thought to be pathology discogenic low back pain. also important for mediating inflammatory pain from via high affinity receptor, TrkA. Recent research has revealed...
It has been thought that lumbar intervertebral discs were innervated segmentally. We have previously shown the L5-L6 disc in rat is bilaterally from L1 and L2 dorsal root ganglia through paravertebral sympathetic trunks, but pathways between trunks unknown. now studied spines of 17 rats to elucidate exact pathways. examined serial sections spine using immunohistochemistry for calcitonin gene-related peptide, a sensory nerve marker. showed these fibres ran sinuvertebral into rami...
In Brief Study Design. Using a retrograde neurotracing method with Fluoro-Gold (FG), the level at which dorsal root ganglions (DRGs) innervate L2 and L5 vertebral bodies innervation pathways were investigated in rats. Objective. To clarify levels DRGs lumbar to determine from DRGs. Summary of Background Data. Elderly patients osteoporosis sometimes experience fracture may also feel diffuse nonlocalized pain back, lateral portion trunk, area surrounding iliac crest. However, pattern sensory...
The purpose of this study is to provide precise anatomical and statistical information about the number location lumbar sympathetic ganglia length related rami communicantes, consider neurological pathway for nociception from low back. Three-hundred ninety-three 719 communicantes 50 human cadavers were identified by gross dissection. in a single chain ranged 2 6, mean being 3.9. lengths connected 1st 5th spinal nerves, respectively, significantly longer shorter than those 2nd, 3rd, 4th...
Study Design. Acute noxious stimulation delivered to lumbar muscles and skin of rats was used study Fos expression patterns in the brain spinal cord. Objectives. The present conducted determine differences cord as evoked by stimuli rats. Summary Background Data. Patients with low back pain sometimes show psychological symptoms, such quiescence, loss interest, decreased activities, appetite loss, restlessness. pathway deep somatic has been reported be different from that cutaneous pain....
Study Design. Neurotracer was applied to various sites in the rat lumbar spine and related tissues. The segmental distribution of labeled neurons dorsal root ganglia (DRG) investigated. Objectives. To clarify stereoscopic structure afferent fibers innervating Summary Background Data. Afferent L5–L6 intervertebral disc are reported originate from L1 L2 DRG. However, anatomic studies determined that each ramus spinal nerve sends nerves elements corresponding vertebra. Methods. Fluorescent...