A5025704557- Asthma and respiratory diseases
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Food Allergy and Anaphylaxis Research
- Osteoarthritis Treatment and Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bone fractures and treatments
- Reproductive Biology and Fertility
- Pediatric health and respiratory diseases
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Thyroid Cancer Diagnosis and Treatment
- Bone and Joint Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Uterine Myomas and Treatments
- Infectious Diseases and Tuberculosis
- Inorganic and Organometallic Chemistry
- Lower Extremity Biomechanics and Pathologies
Kyoto University
1990-2025
Kyoto University Hospital
2020-2025
Hayashi Eye Hospital
2024
University of Rochester Medical Center
2019-2023
Kirin (Japan)
2017
National Center for Geriatrics and Gerontology
2017
The University of Tokyo
1992-2015
National Chemical Laboratory
2015
Osaka University
2015
Komagino Hospital
2008-2013
To determine what kinds of CSF modulate human basophil function, recombinant or purified hemopoietic growth factors were tested for the effect on histamine release from basophils. Both granulocyte (G)-macrophage (M) and IL-3 markedly enhanced upon stimulation with anti-IgE in a dose-dependent manner (maximal enhancement 25.5% by GM-CSF 30.8% as expressed percent increase against total cellular content), whereas G-CSF, M-CSF, IL-4 had no effect. Enhancing action these was still observed...
The incidence and mortality of acute myocardial infarction (AMI) remain low in Japan despite major dietary changes worsening cardiovascular risk factors, a situation that should have resulted substantial increase AMI rates (Japanese paradox). current trend the was examined for period 1990–2001 by use data from Takashima Registry covering stable population approximately 55,000 central Japan. (per 100,000 person-years) 95% confidence intervals were calculated 1990–1992, 1993–1995, 1996–1998,...
Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action human basophils was confirmed using highly purified populations. These observations...
Summary There is increasing evidence for the role of basophils in pathogenesis bronchial asthma. To examine presence airways patients with fatal asthma by immunohistochemistry, we stained lung tissues from four post‐mortem cases who had died severe asthmatic attacks and controls a monoclonal antibody raised against tryptase (AA‐1) anti‐IgE. Mast cells were identified bronchioles as A A‐1‐ anti‐IgE‐positive cells, anti‐IgE‐posilive respectively. Airway mast found beneath basemenl membrane,...
This study evaluated the effect of inhibitors transmethylation on histamine release from rat mast cells and basophilic leukemia cells. IgE-mediated (RBL-2H3 cells) was inhibited by 3-deazaadenosine (DZA) in presence L-homocysteine thiolactone (Hcy) or combination adenosine, erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA), Hcy a dose-dependent fashion. There were no significant changes cellular cAMP levels these inhibitors. Histamine induced anti-IgE dextran normal also blocked DZA plus manner....
Abstract Objectives To describe the learning curve effect of magnetic resonance‐guided focused ultrasound surgery (MRgFUS) on outcomes patients treated for uterine fibroids in four centers Japan. Methods The extent fibroid ablation (often used to measure treatment success) was evaluated using non‐perfused volume (NPV) ratio 287 Japanese patients. were divided into two equal groups according chronological time and results compared between these estimate effect. Results also with published...
Abstract A variety of cytokines have been implicated in the pathogenesis pulmonary sarcoidosis, but exact roles IL-6 and IL-8 are not yet clear. We studied these cytokine levels BALF from patients with idiopathic fibrosis (IPF), systemic screlosis (SSc) interstitial lung disease control subjects. were significantly elevated IPF SSc compared Subjects sarcoidosis had increased both controls when values corrected by total albumin content two correlated each other (r=0.876). percent lymphocytes...
Recent studies have shown that eosinophils are capable of generating and releasing cytokines, providing a novel biologic aspect for regulating allergic inflammation by an autocrine or paracrine mechanism. Eosinophils synthesize various cytokines; however, the physiologic stimuli trigger to generate cytokines not been fully elucidated. We examined effect chemotactic agonists on eosinophil cytokine generation employing determination IL-8 as main parameter. Both C5a FMLP stimulated release...
Osteonecrosis of the femoral head (ONFH) is a refractory disease requiring joint replacement in young patients. Regenerative therapies have been developed.
Background: Eosinophilic inflammation is a crucial aspect of allergic diseases such as bronchial asthma. An eosinophil‐active chemokine, eotaxin, may play role in the pathogenesis tissue eosinophilia accompanying Methods: Induced sputa were obtained from 53 patients with atopic asthma and six healthy subjects, concentration eotaxin sputum was measured by ELISA. We investigated whether content related to 1) status or corticosteroid therapy, 2) other indices, including percentage eosinophils...
Background In Japan, stroke mortality and incidence started to decline during the 1960s. The recent unfavourably diverging trends in risk factors make it uncertain whether will continue. Few comprehensive registries of long research duration exist Japan illustrate incidence. Objective We examined 12-year registration data evaluate current trend a Japanese population. Methods Data were obtained from Takashima Stroke Registry, covering approximately 55000 residents County central Japan....
Staphylococcus aureus is prevalent in surgical site infections (SSI) and leads to death approximately 1% of patients. Phase IIB/III clinical trial results have demonstrated that vaccination against the iron-regulated surface determinant protein B (IsdB) associated with an increased mortality rate patients SSI. Thus, we hypothesized S. induces nonneutralizing anti-IsdB antibodies, which facilitate bacterial entry into leukocytes generate "Trojan horse" disseminate pathogen. Since hemoglobin...
Abstract Background An overhang of the tibial component can cause irritation surrounding soft tissues, whereas an underhang is associated with risks bone resorption. It not well known whether tapering angle currently available blocks at medial, lateral, anterior, and posterior sides matches actual shape proximal tibia. The purpose this study was to analyze bony contour tibia measure examine metal augmentation Methods Computed tomography lower extremities performed on 100 consecutive knees,...
<title>Abstract</title> Purpose Studies on the risk factors affecting progressive vertebral body collapse are scarce. This study aimed to investigate clinical and radiological related following osteoporotic fracture under consistent conservative treatment using a cast. Methods A total of 202 vertebrae (male, 164; female, 38) in 168 patients with acute fractures were examined. The association between difference compression rate first final follow-up visits (> 6 months) factors, including...