A5100778626- Advanced Radiotherapy Techniques
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Animal testing and alternatives
- Growth Hormone and Insulin-like Growth Factors
- Advanced X-ray and CT Imaging
- Food Allergy and Anaphylaxis Research
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Effects of Radiation Exposure
- Orthopaedic implants and arthroplasty
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Inflammatory mediators and NSAID effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
Osaka University
2015-2025
Kobe City Medical Center General Hospital
2010-2024
Hamamatsu University School of Medicine
2020-2024
NTT Medical Center
2018-2024
Nara Medical University
2022-2024
Nara Medical University Hospital
2022-2024
Kao Corporation (Japan)
2011-2023
Kobe University
2020-2023
Fukuoka Dental College
2010-2021
Kobe University Hospital
2020
Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of delta isoform p110 catalytic subunit PI3Ks, we derived enzyme-deficient mice. The mice are viable but have decreased numbers mature B cells, a block in pro-B-cell differentiation, B1 B-cell deficiency. Both immunoglobulin M receptor-induced Ca(2+) flux proliferation response to mitogens attenuated. Immunoglobulin levels substantially. ability respond T-cell-independent antigens...
AbstractOverexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), enzyme which converts to putrescine, plays an important role in diverse biological processes, including cell growth, differentiation, transformation, apoptosis. To explore physiological function of ODC mammalian development, we generated mice harboring a disrupted gene.ODC-heterozygous were viable, normal, fertile. Although zygotic is expressed throughout embryo prior...
Abstract Peritoneal carcinomatosis is a frequent cause of death in patients with advanced gastric carcinoma. Because chemokines are now considered to play an important role the metastasis various malignancies, we hypothesized that they may be involved development peritoneal by Human carcinoma cell lines, which were all highly efficient generating malignant ascites nude mice upon i.p. inoculation, selectively expressed CXCR4 mRNA and protein. In particular, NUGC4 cells at high levels showed...
Abstract Tumor growth and metastasis are dependent on angiogenesis. Vascular endothelial factor (VEGF) plays an important role in the angiogenesis of numerous solid malignancies including colon cancer. Evidence from preclinical clinical studies indicates VEGF is predominant angiogenic human cancer associated with formation metastases poor prognosis. Based these results, it was hypothesized that inhibition receptor activity could inhibit liver metastasis. To test this hypothesis, authors...
Abstract Particle radiotherapy such as proton and carbon ion has been producing promising clinical results worldwide. The purpose of this study was to compare metastatic capabilities malignant tumor cells after irradiation with photon, proton, beams clarify their beam–specific biological effects. We examined the properties highly aggressive HT1080 human fibrosarcoma assess processes in terms cell adhesion capability extracellular matrix, expression integrins, migration, invasive capability,...
Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through recognition by sensors. Here, we investigated role of stimulator interferon genes (STING), cytosolic sensor, in atherogenesis.Apolipoprotein E-deficient (Apoe-/-) mice fed western-type diet (WTD), hypercholesterolaemic mouse model, showed higher STING...
ABSTRACT Patients with tumor-induced osteomalacia (TIO), an acquired paraneoplastic condition characterized by due to hypophosphatemia, exhibit a similar clinical picture those X-linked hypophosphatemic rickets/osteomalacia (XLH). The human monoclonal anti-fibroblast growth factor 23 (FGF23) antibody burosumab (KRN23) increases serum phosphate and improves bone turnover, fracture healing, pain, physical function in XLH patients inhibiting circulating FGF23; thus, is expected be effective...
ABSTRACT Human metapneumovirus (hMPV) has been recently discovered as an etiological agent of acute respiratory infections. Our purpose was to asses the virological and clinical features children with infections caused by hMPV. We examined 658 nasopharyngeal swab samples obtained from 637 for hMPV using reverse transcription-PCR (RT-PCR). A total 268 were inoculated onto tertiary monkey kidney cells. 36 serum (26 in phase 10 convalescent phase) 26 hMPV-positive tested immunoglobulin G (IgG)...
The authors’ recent discovery that glycogen synthase kinase‐3β (GSK‐3β) participates in colon cancer cells’ survival and proliferation prompted us to investigate whether GSK‐3β inhibition alters of cells vivo . Groups four or five athymic mice (Balb/c, nu/nu) with subcutaneous xenografts SW480 human were treated dimethyl sulfoxide (DMSO) different doses (1, 2 5 mg/kg body weight) either small‐molecule inhibitor (SB‐216763 AR‐A014418) by intraperitoneal injection three times per week for...
Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted detect deposits immune complexes and analyse cytological reactions in the aphthous ulcers erythema nodosum (EN)-like eruptions. Deposits IgM positive fluorescence anti-streptococcal D serum were found vessel walls sites infiltrated by inflammatory cells. Cytological analysis has revealed that infiltrating cells are mainly composed activated T-cells...
Carbon ion radiotherapy has been utilized even for X-ray resistant tumors. However, control of distant metastasis remains a major challenge in carbon irradiation. We investigated whether irradiation combined with dual immune checkpoint blockade therapy (anti-PD-L1 and anti-CTLA-4 antibodies [P1C4]) provides anti-tumor efficacy both local sites. A mouse osteosarcoma cell line (LM8) was inoculated into hind legs C3H mice assigned to four groups: no treatment (NoTX), P1C4, 5.3 Gy one leg...
We previously demonstrated an association between vascular endothelial growth factor (VEGF), vessel counts and metastasis in human colon cancer specimens. Mutant p53 has been implicated the regulation of angiogenesis. Immuno-histochemical detection protein associated with gene mutations. sought to determine a correlation (i.e., mutant p53), VEGF expression cancer. Surgical specimens from 93 patients were stained immuno-histochemically for p53, VIII. Vessel greater metastatic tumors than...
The current study attempts to clarify the possible immune response that occurs in medullary carcinoma with lymphocytic infiltration of stomach by an immunohistochemical analysis subpopulations tumor-infiltrating lymphocytes. This was histologically characterized sparse population small nests consisting poorly differentiated cells, widely separated intervening nondesmoplastic stroma infiltrated uniformly abundant lymphocytes frequently accompanied lymph follicles. An revealed T-cells were...
Biochemical and immunohistochemical analyses were done on five cases of gastric carcinoma with excessive production alpha-fetoprotein (AFP). Histologic ultrastructural examination these showed conventional poorly differentiated adenocarcinoma cuboidal or polygonal tumor cells in the medullary area scattered AFP-positive cancer cells. Comparative studies serum AFP between hepatocellular (HCC) testicular yolk sac using concanavalin A (ConA)-affinity lens culinalis agglutinin (LCA)-affinity...
Abstract Background Outcomes after hepatectomy in patients with mass‐forming (MF) type intrahepatic cholangiocarcinoma (ICC) marked enhancement within the tumor on arterial‐phase computed tomography (CT) scans have not been clarified detail. Methods We retrospectively studied 140 MF ICC who underwent from 1989 through 2008. Surgical outcomes were compared between 25 (hypervascular ICC) and 109 without (hypovascular CT scans. Results Portal invasion metastasis significantly lower...