A5086438176- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Nutritional Studies and Diet
- Tea Polyphenols and Effects
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Hip disorders and treatments
- Global Cancer Incidence and Screening
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Ginkgo biloba and Cashew Applications
- Birth, Development, and Health
- Shoulder and Clavicle Injuries
- Phytoestrogen effects and research
- Coffee research and impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Diabetes Research and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Cancer Risks and Factors
Tohoku University
2014-2025
Tohoku Medical Megabank Organization
2012-2025
Kyoto University
2016-2025
Kyoto University Hospital
2016-2024
Graduate School USA
2023
National Research Institute of Fire and Disaster
2018
Astellas Pharma (Japan)
2017
AbbVie (Japan)
2017
Taisho Pharmaceutical (Japan)
2017
Chugai Pharma (United States)
2017
EA IS THE MOST CONSUMED BEVerage in the world aside from water.Three billion kilograms of tea are produced each year worldwide. 1Because high rates consumption global population, even small effects humans could have large implications for public health. 2Tea is generally consumed forms green, oolong, and black tea, all which originate leaves plant Camellia sinensis.4][5][6] Although substantial evidence vitro animal studies indicates that green preparations inhibit CVD carcinogenic...
Background and Purpose— The objectives of the present study were to estimate an annual number patients with moyamoya disease in Japan describe clinicoepidemiological features disease. Methods— consisted 2 questionnaire surveys, which distributed randomly selected departments neurosurgery, internal medicine, neurology, cerebrovascular pediatrics hospitals throughout Japan. first survey inquired about treated 2003, second requested additional detailed information each patient identified...
Highlights•We established hiPSCs that express EGFP in chondrocytes when differentiated•We developed a method for generating scaffoldless hyaline cartilage from hiPSCs•The hiPSC-derived neocartilage integrated into adjacent native articular cartilage•The produced neither tumors nor ectopic tissue vivoSummaryDefects ultimately result loss of joint function. Repairing defects requires cell sources. We an approach to generate human induced pluripotent stem cells (hiPSCs). initially generated...
We evaluated the association of nocturia with fracture and death in a large, community based sample Japanese individuals 70 years old or older.The baseline this population study was determined 2003 by an extensive health interview each participant. In we followed 784 mean ± SD age 76.0 4.6 (range to 97). Information on mortality during period provided National Health Insurance system details fractures were collected from medical records. compared risk bone without multivariate Cox...
Objective: To investigate the association between sense of “life worth living (ikigai)” and cause-specific mortality risk. The psychological factors play important roles in morbidity risks. However, negative risk is inconclusive. Methods: Ohsaki Study, a prospective cohort study, was initiated on 43,391 Japanese adults. assess if subjects found ikigai, they were asked question, “Do you have ikigai your life?” We used Cox regression analysis to calculate hazard ratio all-cause according...
Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and patients with severe angina pectoris. Methods Results: To further confirm the effectiveness safety of SW therapy, 8 pectoris were treated double-blind, placebo-controlled cross-over manner. but not placebo, significantly chest pain symptoms cardiac function without any complications or adverse effects. Conclusions: Extracorporeal is an effective, safe non-invasive therapeutic option...
Objectives To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, nationwide survey was conducted. Methods Patients with AIP who had visited selected hospitals 2007 were surveyed. Autoimmune diagnosed according to Japanese clinical diagnostic criteria 2006. The study consisted 2-stage surveys: number patients estimated by first questionnaire and their assessed second questionnaire. Results total 2790 (95% confidence interval, 2540–3040), an overall...
Abstract Although case‐control studies suggested that coffee consumption is associated with a decreased risk of liver cancer, no prospective cohort study has been carried out. To examine the association between and we conducted pooled analysis data available from 2 in Japan. A self‐administered questionnaire about frequency other health habits was distributed to 22,404 subjects (10,588 men 11,816 women) Cohort 1 38,703 (18,869 19,834 2, aged 40 years or more, previous history cancer. We...
Malrotation of the tibial component can lead to complications after total knee arthroplasty (TKA). Despite reports internal rotation being associated with more severe pain or stiffness than external rotation, biomechanical reasons remain largely unknown. We used a computer simulation model and evaluated traction forces in lateral collateral ligament (LCL) medial (MCL) malrotated during squatting. also examined tibiofemoral patellofemoral contact stresses under similar conditions. A dynamic...
Objectives Little biomechanical information is available about kinematically aligned (KA) total knee arthroplasty (TKA). The purpose of this study was to simulate the kinematics and kinetics after KA TKA mechanically (MA) with four different limb alignments. Materials Methods Bone models were constructed from one volunteer (normal) three patients deformities (slight, moderate severe varus). A dynamic musculoskeletal modelling system used analyse tibiofemoral contact force. stress on tibial...
Unicompartmental knee arthroplasty (UKA) is one surgical option for treating symptomatic medial osteoarthritis. Clinical studies have shown the functional benefits of UKA; however, optimal alignment tibial component still debated. The purpose this study was to evaluate effects coronal and sagittal plane in UKA on kinematics cruciate ligament tension, using a musculoskeletal computer simulation.The first aligned perpendicular mechanical axis tibia, with 7° posterior slope (basic model)....
Abstract To examine the association between cigarette smoking and risk of gastric cancer, we conducted a pooled analysis 2 population‐based prospective cohort studies in rural northern Japan. Cohort 1 included 9,980 men (≥40 years old) 19,412 (40–64 old). The subjects completed self‐administered questionnaire on other health habits. We identified 228 cases cancer among (9 follow‐up with 74,073 person‐years) 223 (7 141,675 person‐years). From each cohort, computed relative (RR) 95% confidence...
The role of adult weight change in breast cancer (BC) risk is unclear Japanese women. A total 10 106 postmenopausal women aged 40–64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases identified. Hazard ratios (HRs) estimated according body mass index (BMI) at the current age 20 years, since years. Higher BMI was associated with an increased (P for trend=0.02), whereas higher inversely this trend=0.002). There a significant association between trend=0.0086). Compared...