A5084232644- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Acute Lymphoblastic Leukemia research
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Contact Dermatitis and Allergies
- Prosthetics and Rehabilitation Robotics
- IL-33, ST2, and ILC Pathways
- Kawasaki Disease and Coronary Complications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Autoimmune and Inflammatory Disorders Research
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Inflammatory Bowel Disease
- Muscle activation and electromyography studies
Gunma University
2014-2023
Japan Pediatric Society
2009-2023
Yokohama City University Medical Center
2023
Yokohama City University
2023
Chuo University
2017-2021
Shimane University
2010
University of Shimane
2010
Nippon Medical School
2009
Biology of Infection
2003
Saku Central Hospital
2000
The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein–2) signal through different receptors transcription factors, namely STATs (signal transducers activators of transcription) Smads. were found to act in synergy on primary fetal neural progenitor cells induce astrocytes. transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus a cytokine stimulation–independent manner, Smad1 carboxyl stimulation–dependent manner. formation complex...
Abstract Asthma is the most common chronic lower respiratory disease in childhood throughout world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there no doubt that use of systematic approaches for management can considerably improve outcomes, dissemination and implementation these still major challenges. Consequently, I nternational C ollaboration Asthma, Allergy Immunology (i CAALL ), recently formed by EAACI , AAAAI...
gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary oncostatin-M, cardiotrophin-1. We have examined this study role nervous system analyzing developmental cell death several neuronal populations differentiation astrocytes gp130-deficient mice. A significant reduction was observed number sensory neurons L5 dorsal root ganglia motoneurons facial...
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections suppress rodent models of T1D. However, the underlying regulatory mechanisms for this protection unclear. Here, we report that CD8+ T (Treg) cells prevent onset streptozotocin -induced by a intestinal nematode. Trehalose derived from nematodes affects microbiota increases abundance Ruminococcus spp.,...
Abstract This is the English version of Clinical Practice Guidelines for Management Atopic Dermatitis 2021. dermatitis (AD) a disease characterized by relapsing eczema with pruritus as primary lesion. In Japan, from perspective evidence‐based medicine, current strategies treatment AD consist three measures: (i) use topical corticosteroids, tacrolimus ointment, and delgocitinib ointment main inflammation; (ii) application emollients to treat cutaneous barrier dysfunction; (iii) avoidance...
The members of the Japanese Society for Pediatric Infectious Diseases and Pulmonology have developed Guidelines Management Respiratory in Children with objective facilitating appropriate diagnosis, treatment prevention respiratory infections children. first edition was published 2004 fifth 2022. Guideline 2022 consists 2 parts, clinical questions commentary, includes general specific children underlying diseases severe infections. This executive summary outlines 2022, reference to Medical...
Leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP) 2 signal via different receptor systems. We have recently demonstrated that simultaneous stimulation of fetal mouse neuroepithelial cells with these distinct types cytokines synergistically induces astrocyte differentiation in a 2‐day culture. Here we show astrocytes spontaneously emerge vitro without exogenously added LIF BMP2 the culture for much longer period. This spontaneous is completely impaired when deficient...
The cryptic t(5;11)(q35;p15.5) creates a fusion gene between the NUP98 and NSD1 genes. To ascertain significance of this fusion, we explored its frequency, clinical impact, expression pattern using DNA microarray in pediatric acute myeloid leukemia (AML) patients. NUP98‐NSD1 transcripts were detected 6 (4.8%) 124 AML Supervised hierarchical clustering analyses probe sets that differentially expressed these patients characteristic pattern, including 18 ‐negative ( ‐like patients). In total,...
Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease. Targeted sequencing efforts have identified several mutations with diagnostic prognostic values in KIT, NPM1, CEBPA FLT3 both adult paediatric AML. In addition, massively parallel enabled the discovery of recurrent (i.e. IDH1/2 DNMT3A) this study, whole-exome (WES) 22 AML patients revealed components cohesin complex (RAD21 SMC3), BCORL1 ASXL2 addition to previously known gene mutations. We also intratumoural...
The aim of this study was to investigate the incidence and risk factors peripherally inserted central venous catheter (PICC)-related complications using a multicenter case survey.A prospective cohort carried out by 19 neonatal intensive care units (NICUs) in Japan from February 2005 March 2007. A total 975 records were collected. PICC-related including pericardial effusion/cardiac tamponade pleural effusion/ascites, removal difficulties, catheter-related bloodstream infection (CR-BSI),...
Abstract Pediatric acute megakaryoblastic leukemia in non‐Down syndrome (AMKL) is a unique subtype of myeloid (AML). Novel CBFA2T3‐GLIS2 and NUP98‐KDM5A fusions recurrently found AMKL were recently reported as poor prognostic factors. However, their detailed clinical molecular characteristics patients treated with recent improved therapies remain uncertain. We analyzed features 44 on two Japanese AML protocols, the AML99 AML‐05 trials. identified , RBM15‐MKL1 KMT2A rearrangements 12 (27%), 4...
Increased incidence and prevalence of pediatric inflammatory bowel disease (IBD) have been reported in Western countries. Changes the IBD Asian countries, however, remain unclear. We evaluated changes among Japanese adults children from 2004 to 2013, by using national registry data patients receiving financial aid. Data (ages 0-19 years) were compared with those young 20-39 years). In 2004, age-standardized prevalences Crohn (CD) ulcerative colitis (UC) 4.2 100,000 11.0 100,000,...
Kawasaki disease (KD; MIM#61175) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD suggest possible involvement the Ca2+/NFAT pathway in pathogenesis KD. ORAI1 Ca2+ release activated (CRAC) channel mediating store-operated entry (SOCE) on plasma membrane. The gene located chromosome 12q24 where positive linkage signal was observed our previous affected sib-pair study A common non-synonymous...
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Pediatric Treatment and Management (JPGL) 2017 into English, which was published by Society Allergy Clinical Immunology. It makes recommendations best practices in management childhood asthma, including acute exacerbations non-pharmacological pharmacological management. These guidelines will be interest to non-specialist physicians involved care children with asthma. In JPGL, JPGL2017 first evidence-based updated...
Background T helper‐type 2 cytokines, such as interleukin‐4 (IL‐4) and IL‐13, may play a central role in allergic diseases. The protein known ‘signal transducers activators of transcription 6’ (STAT‐6) is key factor involved both IL‐4‐ IL‐13‐mediated biological responses. Objective objective this study was to evaluate the possible STAT‐6 gene modulating atopy Japanese population. Methods We screened all 23 exons from 10 subjects for mutations by direct polymerase chain reaction (PCR)...
We reported previously that intravenous immunoglobulin (IVIG) plus prednisolone for initial therapy Kawasaki disease (KD) prevented coronary artery abnormalities (CAA) more effectively than IVIG alone. However, questions remain as to whether PSL has potential benefit in all KD patients. The present study was designed explore the possibility of stratified including patients with and without a high predicted risk being an nonresponder.We retrospectively analyzed data from who received (n =...