A5026601995- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Photosynthetic Processes and Mechanisms
- Caveolin-1 and cellular processes
- TGF-β signaling in diseases
- Polysaccharides and Plant Cell Walls
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Algal biology and biofuel production
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Plant Reproductive Biology
- Protist diversity and phylogeny
- Cellular Mechanics and Interactions
- Plant Molecular Biology Research
- Lysosomal Storage Disorders Research
- Antioxidant Activity and Oxidative Stress
- Bone Metabolism and Diseases
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Axon Guidance and Neuronal Signaling
- Analytical chemistry methods development
- Spaceflight effects on biology
- Microtubule and mitosis dynamics
- ATP Synthase and ATPases Research
University of Waterloo
2010-2023
Purdue University West Lafayette
2012-2022
University of Wisconsin–Madison
2021
Hiroshima University
2012
Augusta University
2004-2011
The University of Tokyo
2001-2009
National Chiayi University
2008
Japan Fine Ceramics Center
2008
Kumamoto University
2001-2007
Seikagaku Corporation (Japan)
2007
The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein–2) signal through different receptors transcription factors, namely STATs (signal transducers activators of transcription) Smads. were found to act in synergy on primary fetal neural progenitor cells induce astrocytes. transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus a cytokine stimulation–independent manner, Smad1 carboxyl stimulation–dependent manner. formation complex...
A potent (Na,K)-ATPase inhibitor purified from Sigma Grade* ATP has been identified as vanadium using electron probe microanalysis and confirmed by microwave-induced emission spectroscopy paramagnetic resonance spectroscopy. Sodium orthovanadate (Na3 VO4) is identical with the respect to ultraviolet absorbance, migration on thin layer chromatography, inhibition of (Na,K)-ATPase. The in-inhibited 50% 40 nM Na3 VO4 under optimal conditions (28 mM Mg2+) 100% reversible millimolar concentrations...
Active transport of aromas Volatile organic compounds (VOCs) serve as invisible lines communication among host plants, pathogens, commensals, community groups, and, with flowers, their pollinators. Studying petunia Adebesin et al. show that VOCs do not passively diffuse out the cells but are actively shuttled across plasma membrane by an ABC (ATP-binding cassette) transporter (see Perspective Eberl and Gershenzon). Disabling results in damage to cell's membranes intracellular accumulation...
We show that when telencephalic neural progenitors are briefly exposed to bone morphogenetic protein 2 (BMP2) in culture, their developmental fate is changed from neuronal cells astrocytic cells. BMP2 significantly reduced the number of expressing microtubule-associated 2, a marker, and nestin, marker for undifferentiated precursors, but increased S100-β, an marker. In neuroepithelial cells, up-regulated expression negative helix–loop–helix (HLH) factors Id1, Id3, Hes-5 (where Hes homologue...
Abstract Glycosphingolipids (GSLs) and their sialic acid‐containing derivatives, gangliosides, are important cellular components abundant in the nervous system. They known to undergo dramatic changes during brain development. However, knowledge on mechanisms underlying qualitative is still fragmentary. In this investigation, we have provided a detailed study developmental of expression patterns GSLs, GM3, GM1, GD3, GD1a, GD2, GD1b, GT1b, GQ1b, A2B5 antigens (c‐series gangliosides such as GT3...
Leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP) 2 signal via different receptor systems. We have recently demonstrated that simultaneous stimulation of fetal mouse neuroepithelial cells with these distinct types cytokines synergistically induces astrocyte differentiation in a 2‐day culture. Here we show astrocytes spontaneously emerge vitro without exogenously added LIF BMP2 the culture for much longer period. This spontaneous is completely impaired when deficient...
Astrocytes play important roles in brain development and injury response. Transcription factors STAT3 Smad1, activated by leukemia inhibitory factor (LIF) bone morphogenetic protein 2 (BMP2), respectively, form a complex with the coactivator p300 to synergistically induce astrocytes from neuroepithelial cells (NECs) (K. Nakashima, M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, Kawabata, K. Miyazono, Taga, Science 284:479-482, 1999). However, mechanisms that govern astrogliogenesis...
A cyclic dimer of methyliridium porphyrin 1Ir shows an extraordinary affinity toward fullerenes via a dynamic bond-forming interaction. The crystal structure inclusion complex 1Ir⊃C60 demonstrates the bond formation between iridium centers and guest C60, leading to ellipsoidal deformation C60. According variable-temperature 13C NMR spectroscopy, included C70 adopts, over wide temperature range, end-on orientation relative metalloporphyrin units, as consequence site-specific onto CC bonds...
Neural stem cells (NSCs) are undifferentiated neural characterized by their high proliferative potential and the capacity for self-renewal with retention of multipotency. Over past two decades, there has been a huge effort to identify NSCs morphologically, genetically, molecular biologically. It is still controversial, however, what bona fide are. To define characterize more systematically, it crucial explore novel cell-surface marker molecules NSCs. In this study, we focused on GD3,...
In the human experience SCARs are permanent reminders of past events, not always based on bad decisions, but those in which an interplay opposing forces leaves behind a clear record form some watery mark. During plant morphogenesis, important proteins that reflect unusual evolutionary outcome, kingdom relies heavily this single class actin-related protein (ARP) 2/3 complex activator to dictate time and place actin filament nucleation. This unusually simple arrangement may serve as reminder...
J. Neurochem. (2011) 116 , 874–880. Abstract Gangliosides are sialic acid‐containing glycosphingolipids abundant in the central nervous tissues. The quantity and expression pattern of gangliosides brain change drastically during early development mainly regulated through stage‐specific glycosyltransferase (ganglioside synthase) genes. It is still unclear, however, how transcriptional activation genes development. In this study, we investigated epigenetic regulation two key...
We here show that bone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 are IL‐6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression glial fibrillary acidic (GFAP). In this synergistic action, transcription factors, Smads STAT3 (for signal transducer activator 3) activated respective group well a transcriptional coactivator p300 were essential. Taken...