Laminin is a basement membrane glycoprotein which consists of A, Bl, and B2 chains. has diverse biological activities including promoting cell adhesion, migration, differentiation, growth, neurite extension. Synthetic peptides from the active region A chain were prepared tested for their activity. 19-mer peptide (designated PA22–2), just above carboxyl globule on long arm chain, was found to promote spreading, outgrowth. By testing smaller sequences within peptide, constituent pentapeptide,...

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Cyclic Dimer of Metalloporphyrin Forms a Highly Stable Inclusion Complex with C60Kentaro Tashiro, Takuzo Aida, Jiang-Yu Zheng, Kazushi Kinbara, Kazuhiko Saigo, Shigeru Sakamoto, and Kentaro YamaguchiView Author Information Department Chemistry Biotechnology, Graduate School Engineering, The University Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Integrated Biosciences, Frontier Sciences, Chemical Analysis Center, Chiba University,...

An amide-appended corannulene derivative (3) with tribranched paraffinic side chains self-assembles into a hexagonal columnar liquid crystalline (LC) mesophase over wide temperature range from 154 to −10 °C. In contrast LC assemblies of planar polycyclic aromatic hydrocarbons, the assembly nonplanar 3 responds an applied electric field and can align homeotropically electrode surface. Even after is switched off, this alignment memorized for long period time unless material heated above...

Eutectogels are an emerging family of soft ionic materials alternative to liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments. Herein, the first example mixed electronic conducting supramolecular eutectogel composites is reported. A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found self-assemble into nanofibrillar networks deep eutectic solvents (DES)/poly(3,4-ethylenedioxythiophene)...

Supramolecular interaction of fullerenes with cyclic dimers metalloporphyrins (1-M, M=central metal ions) showed a pronounced dependence on the nature ions, whereby 1-RhMe/fullerene systems displayed extremely high association constants (ca. 108 M−1) and low dissociation activities. Crystal-structure analysis NMR data suggested charge-transfer van der Waals interactions between host guest. Supporting information for this article is available WWW under http://www.angewandte.com or from...

An acyclic dimer of a dendritic zinc porphyrin bearing six carboxylic acid functionalities (1acid) interacts with fullerenes, such as C60 and C70, to form "supramolecular peapods", composed hydrogen-bonded nanotube fullerenes (3). According TEM, the peapods are very long (>1 mum) have uniform diameter 15 nm. Without forms only heavily entangled, irregular assembly. In contrast 1acid, an ester version without hydrogen-bonding capability (1ester) hardly fullerenes.

Higher fullerenes (>/=C76) were selectively extracted from a fullerene mixture obtained combustion-based industrial production source by cyclic dimers of beta-unsubstituted porphyrin zinc complexes 2C5-2C7 with C5-C7 alkylene spacers as host molecules. Results single extraction the together beta-substituted analogue 2C6 (1C6) and spectroscopic titration 1C6 C60, C70, C96 indicated that selectivity toward higher is much dependent on structure units size cavity. Sequential three-stage...

Reduction of a chiral cerium bisporphyrinate double-decker complex Ce(MOFPP)2 (MOFPP = 5,15-bis(3,5-dimethoxyphenyl)- 10,20-bis(pentafluorophenyl)porphyrin dianion) with sodium anthracenide in dioxane at 20 °C resulted acceleration the porphyrin ligand rotation (= racemization) by factor more than 300. Photoreduction also enhancing activity complex. On other hand, oxidation zirconium Zr(DTP)2 (DTP 5,15-ditolylporphyrin phenoxathiinylium hexachloroantimonate (Phen•+SbCl6-) or FeCl3...

Upon slow admission of MeOH, the enantiomerically pure form chiral amphiphilic porphyrin-fullerene dyad 1 in CH(2)Cl(2) self-assembles at 25 degrees C into nanofibers with a built-in donor/acceptor heterojunction, while its racemic form, under identical conditions, submicrometer-sized spheres arrangement essentially different from that nanofiber assembly. Although cast film latter hardly shows photoconducting profile on micrometer-gap electrodes, former sample clearly displays...

A cyclic dimer of methyliridium porphyrin 1Ir shows an extraordinary affinity toward fullerenes via a dynamic bond-forming interaction. The crystal structure inclusion complex 1Ir⊃C60 demonstrates the bond formation between iridium centers and guest C60, leading to ellipsoidal deformation C60. According variable-temperature 13C NMR spectroscopy, included C70 adopts, over wide temperature range, end-on orientation relative metalloporphyrin units, as consequence site-specific onto CC bonds...

A triply fused copper porphyrin dimer, when site-specifically modified on its periphery with hydrophobic and hydrophilic wedges (1C12/TEG), self-assembles into a columnar liquid crystalline (LC) mesophase over wide-temperature range from -17 to 99 degrees C but gives rise an amorphous solid only (1C12/C12) or (1TEG/TEG). LC film of 1C12/TEG displays at 16 top-class one-dimensional electron mobility (0.27 cm2/V x s), as evaluated maximum flash-photolysis time-resolved microwave conductivity.

Stacked up: Use of scanning tunneling microscopy allows manipulation the upper porphyrin tris(porphyrinato) cerium triple-decker complexes, which are obtained by a new synthetic route on smooth Ag(111) surface (see picture). Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is responsible for content functionality any supporting...

The pathophysiology of lymphoedema is poorly understood. Current treatment options include compression therapy, resection, liposuction and lymphatic microsurgery, but determining the optimal approach for each patient remains challenging.We characterized skin adipose tissue alterations in setting secondary lymphoedema.Morphological histopathological evaluations were conducted 70 specimens collected from 26 female patients with lower-extremity following surgical intervention gynaecological...

Upon binding with C60 and diamines, such as 4,4'-bipyridine (bpy) N,N,N',N'-tetramethylhexane-1,6-diamine (TMHDA), cyclic host 1 possessing two electronically coupled sites displays negative homotropic cooperativity positive heterotropic cooperativity, their ternary mixtures preferentially form inclusion complexes hetero-guest pairs supersetC60*bpy supersetC60*TMHDA under appropriate conditions. Spectroscopic titration profiles in toluene at 20 degrees C demonstrated that the association...

Novel liquid crystalline (LC) semiconductors were prepared from the copper complex of a fused porphyrin dimer as electroactive core by attaching to its periphery dodecyl and semifluoroalkyl side chains site-specifically (P≡Phetero) alone (P≡Phomo). The former latter formed rectangular columnar orthorhombic LC mesophases, respectively, where stacking geometries π-conjugated are quite different one another. Although π-electronic properties units in P≡Phetero P≡Phomo solution substantially...

Optical resolution of nonsubstituted chiral fullerenes such as C(76) is one the most challenging subjects in host-guest chemistry. The novel cyclic host 1(2H), which bears a meso-diaryl-beta-octaethylporphyrin (P(2H)) unit on side and its N-2-acetoxyethyl derivative (P(N-EtOAc)) other, traps enantioselectively cavity furnishes 7% enantiomeric excess single extraction. Control experiments using reference hosts indicated importance high pi-basicity large asymmetric distortion N-substituted...

The cyclic host cyclo-[P(Cu)](2) carrying two covalently connected Cu(II) porphyrin units can accommodate La@C(82), a paramagnetic endohedral metallofullerene, in its cavity to form the inclusion complex cyclo-[P(Cu)](2)⊃La@C(82), which be transformed into caged cage-[P(Cu)](2)⊃La@C(82) by ring-closing olefin metathesis of side-chain olefinic termini. On basis electron spin resonance (ESR) and transient nutation (ESTN) studies, cyclo-[P(Cu)](2)⊃La@C(82) is first ferromagnetically coupled...

The porphyrin–prophyrin distance and the spatial requirements of porphyrin substituents are parameters that influence rotatability ligands in metal bis(porphyrinate)s (shown on right): chiral cerium complexes were much easier to racemize than zirconium complexes. latter rotate response H+.

Upon inclusion complexation with a racemic mixture of chiral fullerene C76 ((+/-)-C76), novel cyclic host (1Rh) composed N-methylporphyrin (PNMe) and methylrhodium porphyrin (PRh) exhibited at 20 degrees C 1H NMR spectral profile diastereoisomerically split signals due to the NH group PNMe. In contrast, because faster guest exchange dynamics, metal-free reference 12H, under identical conditions, did not show any signature such diastereoisomeric splitting. Owing excellent resolution (15.6 Hz)...

The Merrifield solid-phase peptide synthesis technique has been adapted to the of homo- and heterometallic metal−organic complex arrays (MOCAs). A terpyridine-appended Fmoc-protected l-tyrosine derivative was metalated with Pt(II), Rh(III), or Ru(II) ions in solution sequentially coupled at surface functionalized polymeric resin give a metal triad (Rh−Pt−Ru), tetrad (Ru−Rh−Pt−Pt), pentad (Rh−Pt−Ru−Pt−Rh), hexad (Rh−Pt−Ru−Pt−Rh−Pt) specific sequence arrangements. These were cleaved from...

The control of organic molecules, supramolecular complexes and donor-acceptor systems at interfaces is a key issue in the development novel hybrid architectures for regulation charge-carrier transport pathways nanoelectronics or photovoltaics. However, present little known regarding intricate features stacked molecular nanostructures stabilized by noncovalent interactions. Here we explore single molecule level geometry electronic properties model dyads van der Waals interactions on crystal...

A rhodium(III) porphyrin cyclic dimer (1) included carbon nanocluster C120 (2) to form a pi-electronic supramolecular complex (1 superset2), in which 2 oscillated back and forth within its cavity. Spectroscopic titration of 1 with line shape analysis on variable-temperature 1H NMR spectral profiles superset2 reference inclusion complexes toluene-d8, chlorobenzene-d5, dichlorobenzene-d4 indicated that the association constant (Kassoc) oscillation activity are both larger as affinity solvent...

Laminin, a basement membrane glycoprotein, has diverse biological activities including cell adhesion, growth, and differentiation.However, little is known concerning the signal transduction active site involved in growth.In this study, we have shown that laminin 19-mer peptide (PA22-2) from carboxyl-terminal end of long arm A chain, which was previously to promote adhesion neurite outgrowth, stimulate thymidine incorporation growth PC12 cells.Laminin PA22-2 (PA) were also found induce rapid...