A5038334164- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Sarcoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
Osaka National Hospital
2012-2025
Heiwa (Japan)
2019-2024
Seiwa Hospital
2020-2023
Higashiosaka College & Higashiosaka Junior College
2020-2021
Osaka International Cancer Institute
1997-2016
Newcastle University
2015
Royal Hospital for Children
2015
National Hospital Organization
2007-2014
Osaka Hospital
2010
Nagoya Medical Center
2009
Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate relationship between LDGL, we conducted survey for DNA sequences by Southern blot analysis obtained from peripheral blood seven including one CAEBV infection. Interestingly, was detected in sample patient infection, samples four other CD3-LDGL. Moreover, single band joined...
Purpose To improve the prognosis in children with newly diagnosed acute myeloid leukemia (AML) by introducing a dose-dense intensive chemotherapy regimen and an appropriate risk stratification system. Patients Methods Two hundred forty de novo AML were treated continuous cytarabine-based induction therapy stratified to three groups based on initial treatment response, age, WBC at diagnosis cytogenetics. All of patients consolidation including or four courses high-dose cytarabine. Allogeneic...
We studied 50 patients with childhood acute lymphoblastic leukemia (ALL), including 11 T-cell ALL and 39 non-T-cell, non-B-cell ALL. In addition to characterizing surface-antigen expression immunoglobulin-gene rearrangement, we determined whether the receptor β-chain gene also undergoes somatic rearrangement. All had rearrangements of gene, no persistence germline configuration. two these demonstrated both immunoglobulin β-heavy-chain gene. heavy-chain rearrangements; in addition, 10...
The cryptic t(5;11)(q35;p15.5) creates a fusion gene between the NUP98 and NSD1 genes. To ascertain significance of this fusion, we explored its frequency, clinical impact, expression pattern using DNA microarray in pediatric acute myeloid leukemia (AML) patients. NUP98‐NSD1 transcripts were detected 6 (4.8%) 124 AML Supervised hierarchical clustering analyses probe sets that differentially expressed these patients characteristic pattern, including 18 ‐negative ( ‐like patients). In total,...
This retrospective cohort study aimed to determine the predictive relevance of clinical characteristics, additional cytogenetic aberrations, and cKIT RAS mutations, as well evaluate whether specific treatment elements were associated with outcomes in pediatric t(8;21)-positive patients acute myeloid leukemia (AML).Karyotypes 916 t(8;21)-AML reviewed for presence 228 samples screened mutations. Multivariable regression models used assess anthracyclines, cytarabine, etoposide during induction...
Key Points Using RNA-seq in pediatric AML patients, 5 gene rearrangements were newly identified, including NPM1 and RUNX1 rearrangements. unmasked the complexity of alterations by identifying disease-causing nearly all patients.
Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease. Targeted sequencing efforts have identified several mutations with diagnostic prognostic values in KIT, NPM1, CEBPA FLT3 both adult paediatric AML. In addition, massively parallel enabled the discovery of recurrent (i.e. IDH1/2 DNMT3A) this study, whole-exome (WES) 22 AML patients revealed components cohesin complex (RAD21 SMC3), BCORL1 ASXL2 addition to previously known gene mutations. We also intratumoural...
Abstract Background Extramedullary infiltration (EMI) is an occasional clinical symptom in childhood acute myelogenous leukemia (AML), but there considerable controversy regarding the prognostic significance of EMI AML. Procedure We evaluated frequency and at diagnosis AML children. Results Of 240 cases de novo excluding children with Down syndrome promyelocytic leukemia, 56 (23.3%) showed diagnosis. Patients had a higher initial WBC count proportion M4/M5 morphological variants. The...
Purpose To evaluate a less intensive chemotherapeutic regimen specifically designed for patients with Down syndrome (DS) and acute myeloid leukemia (AML), to determine the prognostic factors event-free survival. Patients Methods Seventy-two AML-DS were treated remission induction chemotherapy consisting of pirarubicin (25 mg/m 2 /d days), cytarabine (100 7 etoposide (150 3 days). received four courses intensification therapy same regimen. Prophylaxis CNS was not included. Results All but two...
Abstract Pediatric acute megakaryoblastic leukemia in non‐Down syndrome (AMKL) is a unique subtype of myeloid (AML). Novel CBFA2T3‐GLIS2 and NUP98‐KDM5A fusions recurrently found AMKL were recently reported as poor prognostic factors. However, their detailed clinical molecular characteristics patients treated with recent improved therapies remain uncertain. We analyzed features 44 on two Japanese AML protocols, the AML99 AML‐05 trials. identified , RBM15‐MKL1 KMT2A rearrangements 12 (27%), 4...
A multispecies outbreak of IMP-6 carbapenemase-producing Enterobacterales (IMP-6-CPE) occurred at an acute care hospital in Japan. This study was conducted to understand the mechanisms IMP-6-CPE transmission by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing and whole-genome sequencing (WGS), identify risk factors for acquisition patients who underwent abdominal surgery. Between July 2013 March 2014, 22 hospitalized infected or colonized with (Escherichia coli [n = 8],...
The p53 gene frequently is affected by point mutations, rearrangements, or deletions that contribute to the genesis progression of a wide variety human adult solid tumors; however, authors' knowledge, this alteration has not been analyzed in neuroblastoma.Genomic DNA samples from 20 children with neuroblastoma, including 16 patients advanced disease, were screened for presence mutations exons 5-9 gene, where over 90% have reported be located cancer. screening technique employed polymerase...
Summary Recent reports described the NUP 98‐ NSD 1 fusion as an adverse prognostic marker for acute myeloid leukaemia ( AML ) and PRDM 16 (also known MEL representative overexpressed gene in patients harbouring fusion. expression levels were measured via real‐time polymerase chain reaction 369 paediatric with de novo , of whom 84 (23%) exhibited overexpression / ABL ratio ≥ 0·010). The frequencies high or low differed widely respect to each genetic alteration, follows: t(8;21), 4% vs. 96%, P...
A 10‐year‐old boy with chronic active Epstein‐Barr virus (EBV) infection developed T‐cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes proliferating lymphocytes were CD3 ± , CD4 and HLA‐DR . genomic DNAs from these cells demonstrated two rearranged receptor μ‐chain genes contained EBV genome. These findings indicate that can infect T might cause clonal lymphoproliferation.