A5033824056- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Reproductive tract infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Respiratory and Cough-Related Research
- COVID-19 diagnosis using AI
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Mycology
- Antibiotics Pharmacokinetics and Efficacy
- Urinary and Genital Oncology Studies
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Medical Imaging and Pathology Studies
Kansai Medical University
2021-2025
Kindai University
2023-2024
Kawasaki Medical School Hospital
2021
Kawasaki Medical School
2008-2019
Sapporo Hokuyu Hospital
2019
Higashi Osaka City General Hospital
2019
Kawasaki Hospital
2000-2015
Kurashiki Medical Center
2009
State Key Laboratory of Respiratory Disease
2005-2009
Kurume University
2008
Background. Optimal empiric therapy for hospitalized patients with healthcare-associated pneumonia (HCAP) is uncertain. Methods. We prospectively applied a therapeutic algorithm, based on the presence of risk factors multidrug-resistant (MDR) pathogens in multicenter cohort study 445 patients, including both community-acquired (CAP; n = 124) and HCAP (n 321). Results. MDR were more common (15.3% vs 0.8%, P < .001) than CAP Staphylococcus aureus (11.5% .001); methicillin-resistant S. (6.9%...
The usefulness of the tuberculin skin test (TST) and QuantiFERON TB-2G (QFT-TB) were compared in immunocompromised patients. subjects consisted 252 patients who clinically suspected tuberculosis (TB) infection between April 2005 December 2006. Regarding underlying diseases, 74 had malignant 72 undergoing immunosuppressive treatment, 52 diabetes mellitus, 50 chronic renal failure four HIV infection. While positive rate QFT-TB for diagnosis TB (TB disease or latent infection) was 78.1%, that...
We reevaluated the usefulness of a whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON TB-2G [QFT-TB]; Cellestis) in obtaining differential diagnosis between active tuberculosis (TB) and nontuberculous mycobacteriosis (NTM).The subjects were 50 healthy volunteers, patients with TB, 100 NTM who satisfied diagnostic guidelines American Thoracic Society from April 2005 through June 2006. The tuberculin skin test (TST) QFT-TB performed for all subjects. was every 2...
The present authors assessed risk factors that can promote indeterminate results of QuantiFERON TB-2G (QFT-2G; Cellestis Ltd, Carnegie, Australia) tests. subjects were 704 patients with suspected tuberculosis (TB) and latent TB infection between January 2005 December 2007. QFT-2G test the tuberculin skin (TST) performed for all subjects. If indeterminate, was repeated within 1 month. In total, 72 (10.2%) showed on test. Indeterminate due to positive control failure in 68 (88.9%) negative...
Empiric therapy of pneumonia is currently based on the site acquisition (community or hospital), but could be chosen, risk factors for multidrug-resistant (MDR) pathogens, independent acquisition. We prospectively applied a therapeutic algorithm MDR risks, in multicenter cohort study 1089 patients with 656 community-acquired (CAP), 238 healthcare-associated (HCAP), 140 hospital-acquired (HAP), 55 ventilator-associated (VAP). Approximately 83% were treated according to algorithm, 4.3%...
We report a 67-year-old male patient with known history of sarcoidosis in remission who had recurrent following five-month administration interferon alpha (IFN-α) for chronic hepatitis C. He developed bilateral swelling the parotid glands and diffuse reticulonodular pulmonary parenchymal opacities on chest roentgenograms. Serum angiotensin converting enzyme (ACE) levels soluble IL-2 receptor were high transbronchial lung biopsy revealed noncaseating granulomas. The abnormalities both...
Objective The Japan Respiratory Society documented a new category of guidelines for nursing and healthcare-associated pneumonia (NHCAP), which is distinct from community acquired (CAP). objective this study was to determine the epidemiological differences between NHCAP patients in teaching university hospital hospital. In addition, clarify strategy treatment NHCAP, we investigated role atypical pathogens. Methods We analyzed 250 421 CAP cases 349 374 Results Patient age incidences poor...
Several symptoms are classically thought to be suggestive of pertussis in children, but the diagnostic value these adolescent and adult patients is unclear. We evaluated accuracy clinical findings for early presumptive diagnosis patients. Furthermore, we measured fractional exhaled nitric oxide (FeNO) with regard whether could distinguish eosinophilic inflammation airway pertussis. FeNO not expected associated compared 183 cases laboratory-confirmed using serology polymerase chain reaction...
Epidemiological information is essential in providing appropriate empiric antimicrobial therapy for pneumonia. This study aimed to clarify the epidemiology of community-acquired pneumonia (CAP) by conducting a systematic review published studies Japan.Systematic review.PubMed and Ichushi web database (January 1970 October 2022).Clinical describing pathogenic micro-organisms CAP written English or Japanese, excluding on other than adult CAP, investigations limited specific pathogens case...
ABSTRACT In the post-acute coronavirus disease 2019 (COVID-19) period, patients with asthma had a significantly higher risk of cough than without history asthma. particular, cases persistent were increased during Omicron variant epidemic. this study, we evaluated efficacy ensitrelvir for treatment associated COVID-19 variants in This follows Strengthening Reporting Observational Studies Epidemiology statement. A total 223 registered study: 121 chose ensitrelvir, and 102 symptomatic...
Summary The morphology of a recently isolated strain Chlamydia pneumoniae, YK-41, was compared by electronmicroscopy with C. pneumoniae TWAR, trachomatis L2/434/Bu and psittaci Cal 10. results showed that "pear-shaped" not typical pneumoniae. Basic morphological features, such as surface projections hexagonally arrayed, regular structures in the inside layer outer membrane elementary bodies, were very similar these strains. structure YK-41 identical psittaci, but profiles bodies different...
To investigate the characteristic clinical features of chronic necrotizing pulmonary aspergillosis (CNPA) as a complication Mycobacterium avium complex (MAC) disease.Clinical analysis nine cases without history old tuberculosis in whom CNPA was found to be during follow-up period for MAC disease.The average duration from diagnosis disease 36.0 months. Five patients received antituberculous therapy including clarithromycin disease, but this treatment ineffective most. A positive culture...
Through the use of QuantiFERON-TB Gold, a commercial IFN-γ assay, we compared differences in quantitative T-cell responses to Mycobacterium tuberculosis (MTB)-specific antigens [QuantiFERON TB-2G (QFT-2G)] between patients with active (TB) disease and those latent TB infection (LTBI). The patient group consisted 180 (culture-positive for MTB) 50 screening contacts LTBI-positive response QFT-2G test. We prospectively performed tuberculin skin test (TST) all subjects. median levels upon...