A5007801419- Aquaculture Nutrition and Growth
- Physiological and biochemical adaptations
- Renin-Angiotensin System Studies
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Fish Biology and Ecology Studies
- Reproductive biology and impacts on aquatic species
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Heart Failure Treatment and Management
- Protein Hydrolysis and Bioactive Peptides
- Fish Ecology and Management Studies
- Neurobiology and Insect Physiology Research
- Fish biology, ecology, and behavior
- Hormonal Regulation and Hypertension
- Ichthyology and Marine Biology
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Insect Resistance and Genetics
- Pulmonary Hypertension Research and Treatments
The University of Tokyo
2015-2024
Nara Medical University
2022
Mie University
2008-2019
Mie University Hospital
2017
Tokyo University of Science
1997-2017
Sphere Institute
2011-2016
Tsu City College
2016
Chiba University
2015
Chiba Cancer Center
2015
Hokkaido University
1952-2014
Laboratory procedures were compared with brain biopsy findings in 113 biopsy-proven patients herpes simplex virus (HSV) encephalitis and 93 biopsy-negative individuals. Examinations of tissue by histopathology, immunofluorescence, electron microscopy demonstrated evidence HSV infection 56%, 70%, 45% proven cases apparently false-positive results 14%, 9% 2% those biopsy-negative. Serologic assessments revealed that occurred as both a primary (30%) recurrent (70%) infection. Among...
<b>Objective</b> To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk pneumonia. <b>Design</b> Prospective, randomised, placebo controlled double blind study. <b>Setting</b> Nursing homes Japan. <b>Participants</b> 1006 nursing home residents. <b>Interventions</b> Participants were randomly allocated to either (n=502) or (n=504). <b>Main outcome measures</b> The primary end points incidence all cause pneumonia and Secondary deaths from...
We have identified cDNA encoding a new member of the adrenomedullin (AM) family, AM2, for first time in mammals (mouse, rat and human). The predicted precursor carried mature AM2 C‐terminus, which had an intramolecular ring formed by S–S bond possibly amidated C‐terminus. Phylogenetic analyses clustered AM into two distinct but closely related groups. Similarity exon–intron structure synteny neighboring genes showed that mammalian is ortholog pufferfish paralog AM. mRNA was expressed...
To investigate the role of Maillard reaction in pathogenesis diabetic complications, we produced several clones monoclonal antibodies against advanced glycation end products (AGEs) by immunizing mice with AGE-modified keyhole limpet hemocyanin, and found that one clone (AG-1) anti-AGE reacted specifically imidazolones A B, novel AGEs. Thus, imidazolones, which are guanidino group arginine 3-deoxyglucosone (3-DG), a reactive intermediate reaction, were to be common epitopes proteins vitro. We...
Background. Optimal empiric therapy for hospitalized patients with healthcare-associated pneumonia (HCAP) is uncertain. Methods. We prospectively applied a therapeutic algorithm, based on the presence of risk factors multidrug-resistant (MDR) pathogens in multicenter cohort study 445 patients, including both community-acquired (CAP; n = 124) and HCAP (n 321). Results. MDR were more common (15.3% vs 0.8%, P < .001) than CAP Staphylococcus aureus (11.5% .001); methicillin-resistant S. (6.9%...
The genus Oryzias containing freshwater (FW) and seawater (SW) species is a potential model for studying mechanisms of osmotic adaptation. In this study, we compared SW adaptability four species, O. javanicus, dancena, latipes marmoratus inhabiting different environments. was evaluated at several stages the lifecycle: (i) survival rates adult fish after transfer from FW to 50%SW or SW, (ii) spawning ability in (iii) fertilization (iv) hatching FW, SW. Results obtained agreed with natural...
Subacute necrotizing encephalopathy (SNE) or Leigh9s disease is associated with various defects in oxidative phosphorylation (OXPHOS). However, the relationships between these OXPHOS and nuclear DNA mitochondrial (mtDNA) mutations still unclear. We evaluated three SNE pedigrees (two singleton cases a pedigree) biochemically for abnormalities genetically four mtDNA point mutations. There was complex I defect ail that III two individuals. An mutation ATPase, subunit 6 gene (np 8993) present...
Natriuretic peptides (NPs) are major cardiovascular and osmoregulatory hormones in vertebrates. Although tetrapods generally have three subtypes, atrial NP (ANP), B-type (BNP), C-type (CNP), some teleosts lack BNP, sharks hagfish only one NP. Thus, NPs diverged during fish evolution, possibly reflecting changes systems. In this study, we found, by cDNA cloning, four distinct CNPs (1 through 4) the medaka (Oryzias latipes) puffer (Takifugu rubripes), although to our knowledge no more than two...
Although the oxidative stress frequently occurs in patients with chronic hepatitis C, its role future hepatocellular carcinoma (HCC) development is unknown. Hepatic 8-hydroxydeoxyguanosine (8-OHdG) was quantified using liver biopsy samples from 118 naïve who underwent 1995 to 2001. The predictability of 8-OHdG for HCC and relations epidemiologic, biochemical histological baseline characteristics were evaluated. During follow-up period (mean 6.7±3.3 years), identified 36 (30.5%). Univariate...
Summary. 8‐Hydroxydeoxyguanosine (8‐OHdG) is a promutagenic DNA lesion produced by hydroxyl radicals and recognized as useful marker in estimating damage induced oxidative stress. The aim of this study was to clarify the clinical significance hepatic 8‐OHdG levels patients with chronic viral hepatitis. Hepatic accumulation investigated hepatitis C (CH‐C) ( n = 77) B (CH‐B) 34) immunohistochemical staining liver biopsy samples. positive hepatocytes were significantly higher CH‐C compared CH‐B...
Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients.M Castillo, P C Davis, Y Takei J Hoffman, JrAudio Available | Share
This study was designed to investigate the mechanism for ethanol-induced hepatic vasoconstriction in isolated perfused rat liver. Upon initiation of ethanol infusion into portal vein at concentrations ranging from 25 100 mM, pressure began increase a concentration-dependent manner and reached maximal levels 2-5 min (initial phase), followed by gradual decrease over period (escape phenomenon). Endothelin-1 antiserum significantly inhibited this 45-80%. Cessation endothelin-1 subsequent...
Lectins, a group of proteins that bind to cell surface carbohydrates and play important roles in innate immunity, are widely used experimentally distinguish types induce proliferation. Eel serum lectins have been useful as anti-H hemagglutinins also lectin histochemistry fucose-binding (fucolectins), but their structures not determined. Here we report the primary sites synthesis eel fucolectins. fucolectins were separated by two-dimensional gel electrophoresis sequenced. cDNA cloning, based...
Abstract Three cases of an entirely suprasellar symptomatic Rathke's cleft cyst, two which were associated with normal sella turcicas, are reported. In all cases, the cysts caused compression optic chiasm, and produced hypothalamic dysfunction. The diagnosis these masses was enhanced by metrizamide cisternography. Two treated frontal craniotomy one transsphenoidally, good results in cases. radiology, pathology, surgical treatment unusual is presented. An embryological pathogenesis for...
Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined effects of intracerebroventricular (icv) and iv injection ghrelin water intake, food urine volume in rats deprived for 24 h. Water intake that occurred after deprivation was significantly inhibited by icv (0.1, 1, 10 nmol/rat) dose-related manner, although stimulated hormone. The antidipsogenic effect effect. Similarly, inhibited, whereas dose dependently nmol/kg). inhibition drinking...