A5101521602- Sarcoma Diagnosis and Treatment
- Nerve injury and regeneration
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Elbow and Forearm Trauma Treatment
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Airway Management and Intubation Techniques
- Surgical site infection prevention
- Plant tissue culture and regeneration
- Peripheral Nerve Disorders
- Pancreatic and Hepatic Oncology Research
- Organ and Tissue Transplantation Research
- Electrospun Nanofibers in Biomedical Applications
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
Kyoto University
2015-2024
Kyoto University Hospital
2012-2024
University of the Ryukyus
2010-2024
Keio University
2021-2024
Orthopedic One
2022
The University of Tokyo
2006-2021
Kurume University
2021
Saga University
2021
Kyoto University of Education
2021
Maebashi Red Cross Hospital
2019
<b>Objective</b> To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk pneumonia. <b>Design</b> Prospective, randomised, placebo controlled double blind study. <b>Setting</b> Nursing homes Japan. <b>Participants</b> 1006 nursing home residents. <b>Interventions</b> Participants were randomly allocated to either (n=502) or (n=504). <b>Main outcome measures</b> The primary end points incidence all cause pneumonia and Secondary deaths from...
Abstract We have developed a new poly(vinyl alcohol) hydrogel (PVA‐H) of increased physical strength through manufacturing process. Its mechanical properties been found to be preferable as substitute for articular cartilage. To evaluate its biocompatibility an artificial cartilage, series in vivo tests within the intraarticular, well intramuscular, environment were conducted. Tissue reactions bone, synovium, and muscle PVA‐H studied histologically. In experimental group, which was implanted,...
Abstract Background The use of Bio 3D nerve conduits is a promising approach for peripheral reconstruction. This study aimed to assess their safety in three patients with defects hands. Methods We describe single institution, non-blinded, non-randomised control trial conducted at Kyoto University Hospital. Eligibility criteria included severed injuries or defect the region distal wrist joint not caused by congenital anomaly; length ≤20 mm diameter ≤2 mm; failed results sensory functional...
Isogeneic and allogeneic chondrocytes cultured in collagen gel were transplanted into osteochondral defects knee joints of inbred strains rats. At 12 weeks, all eight isografted had healed successfully, compared with only four allografted (p 0.05). 26 52 except one successfully there was no significant difference the success rate between groups. Control that been implanted did not heal successfully.
Cells, scaffolds, growth factors, and vascularity are essential for nerve regeneration. Previously, we reported that the insertion of a vascular bundle implantation bone marrow-derived mesenchymal stem cells (BM-MSCs) into conduit promoted peripheral In this study, efficacy conduits containing bundle, BM-MSCs, thermally decellularized allogenic matrix (DANM) was investigated using rat sciatic model with 20-mm defect. Lewis rats were used as preparation Dark Agouti DANM. The revascularization...
The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed bridgehead olefin and C-5/C-13 hydroxy groups in one-step operation. novel Ag-promoted oxetane formation smoothly constructed tetracyclic framework paclitaxel.
Abstract Introduction Recycled bone autografts prepared using extracorporeal irradiation (ECIR) or liquid nitrogen freezing (LNF) methods have been used for the reconstruction of skeletal elements after wide resection sarcomas involving tissues. Few reports include long‐term follow‐up data histological analyses recycled autografts, particularly in case ECIR autografts. Materials A total 34 malignant and soft tissue tumors were resected reconstructed 11 ECIR‐ 23 LNF‐recycled autografts; mean...
The control of the selectivity is a central issue in total synthesis complex natural products. In this paper, we report (±)-keramaphidin B and (±)-ingenamine. key reaction DMAP-catalyzed Diels–Alder which regioselectivity completely controlled by dynamic crystallization. Our successfully demonstrates that crystallization can be an alternative when not either kinetic or thermodynamic approaches solution.
Previously, we showed that undifferentiated bone marrow stromal cell (uBMSC) implantation and vessel insertion into a nerve conduit facilitated peripheral regeneration in rodent model. In this study, investigated the efficacy of uBMSC-laden vessel-containing repair segmental defects, using canine Eight beagle dogs were used study. Thirty-millimeter ulnar defects repaired with conduits (right forelimbs, n = 8) or autografts (left 7). group, artery was inserted l-lactide/ε-caprolactone tube,...
Previously, we developed a Bio3D conduit fabricated from human fibroblasts and reported significantly better outcome compared with artificial nerve in the treatment of rat sciatic defect. The purpose this study is to investigate long-term safety regeneration treatments using autologous transplantation.We used 15 immunodeficient rats randomly divided them into three groups treated (
The involvement of cdc2 and cdk2 during neuronal differentiation in rat pheochromocytoma PC12 cells was examined. When were cultured with nerve growth factor (NGF), expression decreased significantly after day 5, while gradually 7. Cells overexpressing or resistant to NGF-induced suppression, maintained high kinase activity, respectively, NGF treatment. In contrast, the NGF-treated parental showed a marked decline these activities 3. treated specific inhibitors cdc2/cdk2 (butyrolactone-I,...
Abstract Background and Aim: The Cancer of the Liver Italian Program (CLIP) score has been demonstrated to have superior prognostic ability in hepatocellular carcinoma (HCC) patients worldwide, but there never sufficient assessment efficacy treatment modalities according CLIP score. This retrospective cohort study HCC was conducted assess Methods: We compared hepatic resection (HR) ( n = 101), radiofrequency ablation with prior transcatheter arterial chemoembolization (RFA + TACE) 115),...
To report the outcomes of mallet fractures treated with our modified tension band wiring technique.Eleven men and two women (mean age; 33 years) in which happened more than five weeks before surgery, or fracture fragments involving 2/3 less 1/3 distal phalanx articular surface previous surgical intervention, were subjected to this study. The fragment was fixed a technique using stainless steel wire an injection needle.All patients achieved bone union nine average. All had no pain except one...
Abstract Background The reduction of systemic immunosuppressive agents is essential for the expansion vascularized composite allotransplantation (VCA) in a clinical setting. purpose this study to compare human‐induced pluripotent stem cell‐derived mesenchymal cells (iMSCs) with four other types (human bone marrow‐derived MSCs [BMMSCs], human adipose‐derived [ADMSCs], rat BMMSCs, and ADMSCs) vitro, investigate vivo immunomodulatory effect iMSCs VCA model. Materials methods One Brown Norway...
Background/Aim: Despite the well-publicized clinical outcomes after unplanned excision (UE) and re-excision (re-excision) in patients with soft-tissue sarcoma (STS), there is little information about real-life referral patterns for UE, such as patient profile, details of procedures, subsequent management UE. We aimed to investigate characteristics UE who were referred sarcoma-specific centers. Patients Methods: Between May 2022 June 2023, we registered 97 underwent centers Japan. excluded...
Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize deficiency cycle peripheral tissues. Analysis of clock over 24-36 hour period multiple tissues including callus, proximal tibia growth plate and cardiac after 12 days on diet higher levels gene hypophosphatemia groups (p < 0.001) 3 6 elongation cycle. A comparative callus tissue transcriptome were...