A5077447497- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Virology and Viral Diseases
- Parvovirus B19 Infection Studies
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Neonatal Health and Biochemistry
- Herpesvirus Infections and Treatments
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Animal Virus Infections Studies
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
National Mie Hospital
2016-2025
Mie University
1994-2022
Japan Pediatric Society
2020-2022
Kyoto University
1991-2020
Nagoya City University
2018-2020
National Institute of Infectious Diseases
2018-2020
Vanuatu Cultural Centre
2016-2017
Japanese Society for Dialysis Therapy
2016
Pediatrics and Genetics
2007
C-type natriuretic peptide (CNP), the third member of family, is thus far known to be distributed mainly in central nervous system and considered act as a neuropeptide, contrast atrial (ANP) brain (BNP), which cardiac hormones. Recently, we others have demonstrated that ANP-B receptor, selectively activated by CNP, localized not only but peripheral tissues, including blood vessels. This finding has made us speculate regarding production CNP. In present study, cultured endothelial cells were...
To study synthesis, storage, and secretion of brain natriuretic peptide (BNP) in the heart, we have measured BNP mRNA concentrations hearts Wistar-Kyoto rats also investigated its from isolated perfused heart. The atrium expressed gene at a high level, considerable amount was present ventricle, which corresponded to approximately 40% atrial concentration. When tissue weight taken into account, total content ventricle threefold larger than that atrium, although (ANP) only 7% atrium. By...
BACKGROUND Brain natriuretic peptide (BNP), as a cardiac hormone, is expressed together with atrial (ANP) in the ventricles congestive heart failure. However, ventricular expression of BNP hypertrophic cardiomyopathy (HCM) normal systolic function still unclear. METHODS AND RESULTS The study population consisted 39 HCM patients asymmetric septal hypertrophy and 10 control subjects without any specific disease. Eleven cases were obstructive (HOCM), other 28 nonobstructive (HNCM). All these...
Pneumococcal infection in children is a major public health problem worldwide, including Japan. The pneumococcal conjugate vaccine 7 (PCV7) was licensed for use Japan 2010 followed by PCV13 2013. This report includes the results of nationwide surveillance invasive disease (IPD) and non-IPD paediatric patients from January 2012 to December 2014. We collected 343 isolates 337 IPD 286 278 patients. Of isolates, most identified serotypes included 19A, 24F, 15A. prevalence non-PCV13 serotype...
Continuing emergence of variants concern resulting in reduced SARS-CoV-2 vaccine efficacy necessitates additional prevention strategies. The structure VLPCOV-01, a lipid nanoparticle-encapsulated, self-amplifying RNA COVID-19 with comparable immune response to BNT162b2, was revised by incorporating modified base, 5-methylcytosine, reduce reactogenicity, and an updated receptor-binding domain derived from the Brazil (gamma) variant. Interim analyses phase 1 dose-escalation booster vaccination...
Abstract We have isolated and characterized the gene for human endothelin-A receptor. Southern blot analyses demonstrated a single copy The spans more than 40 kilobases contains eight exons seven introns. Intron 1 exists in 5'-noncoding region, introns 2-7 occur coding region. locations of exist before or after regions encoding membrane-spanning domains. transcription start site, determined by primer extension experiments, is 502 base pairs upstream methionine initiation codon. 5'-flanking...
Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence all ages. Serotype-specific IPD cases population denominators were obtained directly from surveillance sites using PCV10 or PCV13 national immunisation programmes with a primary series uptake of at least 50%. Annual rate ratios (IRRs) estimated comparing the before any PCV each year post-PCV10...
Fusion regulatory protein (FRP)-1 regulates virus-mediated cell fusion and of monocytes. Eleven fifteen N-terminal amino acids FRP-1 were the same as acid sequence 4F2/CD98 heavy chain. molecules detected in Con A- or IL-2-stimulated lymphocytes, while was rare on resting lymphocytes. These properties are similar to those 4F2/CD98. Treatment monocytes with anti-4F2/CD98 mAbs resulted fusion, other directed against induced formation multinucleated giant cells Cd+U2ME-7 cells, a CD4+U937 line...
Eosinophilic inflammation and remodeling of the airways including subepithelial fibrosis myofibroblast hyperplasia are characteristic pathological findings bronchial asthma. Epithelial to mesenchymal transition (EMT) plays a critical role in airway remodelling. In this study, we hypothesized that infiltrating eosinophils promote remodelling To demonstrate hypothesis evaluated effect on EMT by vitro vivo studies. was assessed mice received intra-tracheal instillation mouse bone marrow derived...
Empiric therapy of pneumonia is currently based on the site acquisition (community or hospital), but could be chosen, risk factors for multidrug-resistant (MDR) pathogens, independent acquisition. We prospectively applied a therapeutic algorithm MDR risks, in multicenter cohort study 1089 patients with 656 community-acquired (CAP), 238 healthcare-associated (HCAP), 140 hospital-acquired (HAP), 55 ventilator-associated (VAP). Approximately 83% were treated according to algorithm, 4.3%...
The emergence and rapid spread of novel DS‐1‐like intergenogroup reassortant rotaviruses having the equine‐like G3 genotype (DS‐1‐like G3P[8] strains) have been recently reported from several countries. During rotavirus surveillance in Japan 2015–2016, three strains were identified children with severe diarrhea. In present study, we sequenced characterized full genomes these strains. On full‐genomic analysis, all showed a unique constellation including both genogroup 1 2 genes:...
Abstract After the introduction of pneumococcal conjugate vaccines, incidence infections due to meropenem-resistant serotype 15A-ST63 strains increased in Japan. By using whole-genome sequencing and comparing sequences with those clones from United Kingdom, States, Canada, we clarified traits clone. Our analysis revealed that Japan originated meropenem-susceptible Recombination site prediction showed strain-specific recombination regions included pbp1a pbp2b regions. A detailed composition...
Fusion regulatory proteins (FRPs) are newly defined cell surface molecules that enhance and/or induce virus-mediated fusion. Anti-FRP-1 Abs reacted with all of the established cells derived from humans and monkeys, whereas FRPs were found to be selectively expressed on a fraction monocytes in human PBMCs. Granulocytes no FRP-1 molecules, but approximately 18% granulocytes FRP-2 molecules. Alveolar macrophages also expression was enhanced by culture monocytes, CD14 not influenced cultivation....
Background: Nationwide surveillance was conducted in Japan to clarify the status of pediatric invasive pneumococcal diseases (IPD) after introducing a 13-valent conjugate vaccine (PCV13).Methods: Detailed clinical and epidemiologic information IPD cases children aged <15 years were collected from 10 47 prefectures January 2014 December 2022. Streptococcus pneumoniae strains isolated sterile body sites analyzed, including capsular serotypes, multi-locus sequence typing (MLST), antimicrobial...
Nationwide surveillance was conducted in Japan to clarify the status of pediatric invasive pneumococcal diseases (IPD) after introducing a 13-valent conjugate vaccine (PCV13). Detailed clinical and epidemiologic information IPD cases children aged <15 years collected from 10 47 prefectures January 2014 December 2022. Streptococcus pneumoniae strains isolated sterile body sites were analyzed including capsular serotypes, multi-locus sequence typing (MLST), antimicrobial susceptibility...
Colonization by SA is associated with exacerbation of AD. Eosinophilic inflammation a cardinal pathological feature AD, but little known about possible direct interaction between and eosinophils. PAFR appears to be involved in phagocytosis Gram-positive bacteria leukocytes. The objective this study was investigate whether directly induces eosinophil effector functions via the context AD pathogenesis. Peripheral blood eosinophils were cultured heat-killed SA, EDN release, superoxide...
Background: The clinical features of coronavirus disease 2019 (COVID-19) in children have been changing because the emergence and rapid spread variants concern (VOC). increase cases infected with VOC has brought persistent symptoms after COVID-19 children. This survey aimed to analyze manifestations pediatric Japan. Methods: We analyzed reported between February 2020 April 2022 Japan, using a dedicated database updated voluntarily by members Japan Pediatric Society. Using same database, we...
Adenoviruses are associated with a variety of diseases including upper respiratory tract infections, acute conjunctivitis, cystitis and gastroenteritis. can also cause fatal disseminated infections in patients undergoing stem cell transplantation. Measurement adenovirus load clinical samples from localized or may provide important information for analyzing the pathogenesis various infections. The purpose present study was to develop optimize highly sensitive real-time polymerase chain...
Three natriuretic peptide receptors (the ANP-A, ANP-B, and clearance (C) receptors) have been reported. The regulation of these by catecholamines was examined in cultured rat vascular smooth muscle cells. Treatment with norepinephrine decreased the maximum 125I-ANP binding. competitive binding assay des[Gln18,Ser19,Gly20,Leu21, Gly22]ANP-(4-23)-NH2 (C-ANF-4-23), a specific ligand for C receptor, revealed that decrease caused down-regulation receptor. Isoproterenol also down-regulated...