A5020297413- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- DNA Repair Mechanisms
- Eosinophilic Disorders and Syndromes
- Respiratory viral infections research
- Antimicrobial Peptides and Activities
- Urticaria and Related Conditions
- SARS-CoV-2 and COVID-19 Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Contact Dermatitis and Allergies
- Cystic Fibrosis Research Advances
- Immunotherapy and Immune Responses
- Congenital Heart Disease Studies
- Cancer therapeutics and mechanisms
- COVID-19 Clinical Research Studies
- Mast cells and histamine
Baylor College of Medicine
2020-2024
The University of Texas Medical Branch at Galveston
2014-2021
Mie University
2008-2017
Hallym University
2015
Hospital Regional Universitario de Málaga
2015
Instituto de Investigación Biomédica de Málaga
2015
Philipps University of Marburg
2015
Universidad Complutense de Madrid
2015
Cells Therapy (Poland)
2015
Medical University of Lodz
2015
We sought to identify cells and cytokines in bronchoalveolar lavage (BAL) fluids that distinguish asthma from healthy control subjects those controlled uncontrolled asthma. Following informed consent, 36 human were recruited for this study. These included 11 subjects, 15 with FEV1≥80% predicted 10 FEV1 <80% predicted. BAL fluid was obtained all subjects. The numbers of different cell types the levels 48 measured these fluids. Compared patients had significantly more percentages eosinophils...
Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine biological role of these DGs, null animal models have been generated. Here, we report generation and characterization mice lacking Neil2 (Nei-like 2). As in deficient each other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, NEIL3), Neil2-null show no overt phenotype....
For in vitro diagnosis of wheat allergy, specific IgE to is known be a poor predictive marker. Oral food challenge, the gold standard for diagnosis, accompanied by risk severe induced reactions. Reliable tests are needed developed safe indication oral challenge. We examined utility basophil activation marker, CD203c, IgE-mediated allergy. Fifty-eight children with suspected allergy positive CAP-FEIA were enrolled. On 70 occasions, clinical distinction between patients (WA) and tolerant (TW)...
Eosinophilic inflammation and remodeling of the airways including subepithelial fibrosis myofibroblast hyperplasia are characteristic pathological findings bronchial asthma. Epithelial to mesenchymal transition (EMT) plays a critical role in airway remodelling. In this study, we hypothesized that infiltrating eosinophils promote remodelling To demonstrate hypothesis evaluated effect on EMT by vitro vivo studies. was assessed mice received intra-tracheal instillation mouse bone marrow derived...
Neutrophil recruitment is a hallmark of rapid innate immune responses. Exposure airways naive mice to pollens rapidly induces neutrophil recruitment. The mechanisms that regulate pollen-induced and the contribution this neutrophilic response subsequent induction allergic sensitization inflammation need be elucidated. Here we show ragweed pollen extract (RWPE) challenge in C-X-C motif ligand (CXCL) chemokine synthesis, which stimulates (C-X-C motif) receptor 2 (CXCR2)-dependent neutrophils...
<i>Background:</i> Rush immunotherapy (RIT) can confer rapid clinical benefit on patients with allergic rhinitis or asthma. However, biomarkers representing mechanisms for the efficacy of RIT are still to be established. CD203c is a basophil activation marker known upregulated by cross-linking Fc&#917;RIα receptor and may serve as useful marker. <i>Objective:</i> We sought investigate changes in allergen-induced expression Japanese cedar pollen (JCP) pollinosis...
Colonization by SA is associated with exacerbation of AD. Eosinophilic inflammation a cardinal pathological feature AD, but little known about possible direct interaction between and eosinophils. PAFR appears to be involved in phagocytosis Gram-positive bacteria leukocytes. The objective this study was investigate whether directly induces eosinophil effector functions via the context AD pathogenesis. Peripheral blood eosinophils were cultured heat-killed SA, EDN release, superoxide...
Abstract SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces genome activates DNA pathways. To test whether the compromised repair capacity individuals modulates severity infection, we analyze gene expression publicly available patient datasets observe a lower level glycosylase NEIL2 lungs severely infected patients. This observation levels is further validated patients, hamsters...
Background: Epidemiological studies suggest that vitamin D may be protective against the inception and exacerbation of allergic diseases. However, direct effect on eosinophils, major effector cells in inflammation, is not known. It has been reported C-X-C chemokine receptor type 4 (CXCR4) eosinophils induced non-Th2 cytokine milieu or response to glucocorticoids, recruiting cell noninflammatory sites. Objectives: To test whether 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3 calcitriol], active...
Aberrant or constitutive activation of nuclear factor kappa B (NF-κB) contributes to various human inflammatory diseases and malignancies via the upregulation genes involved in cell proliferation, survival, angiogenesis, inflammation, metastasis. Thus, inhibition NF-κB signaling has potential for therapeutic applications cancer diseases. We reported previously that Nei-like DNA glycosylase 2 (NEIL2), a mammalian glycosylase, is preferential repair oxidized bases from transcriptionally active...
<i>Background:</i> Recent evidence suggests that both neutrophilic and eosinophilic inflammation persist in the airways of patients with severe asthma. Mechanisms for interaction between neutrophils eosinophils are still to be understood. Since express protease-activated receptor 2, neutrophil-derived serine proteases may activate eosinophils. <i>Objective:</i> We investigated effect neutrophil on eosinophil effector functions. <i>Methods:</i> Peripheral...
<h3>Background</h3> Myoclonic epilepsy with ragged-red fibres (MERRF) and mitochondrial encephalopathy, lactic acidosis stroke-like episodes (MELAS) are established phenotypes of encephalomyopathy. The m.8356T>C transition in the tRNA<sup>Lys</sup> gene is a pathogenic mutations MERRF. m.3243A>G tRNA<sup>Leu</sup> detected most MELAS patients. Although previous analyses double DNA (mtDNA) were useful for discussing their nature, many unsolved questions remain. <h3>Objective</h3> To...