A5102804483- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aging, Health, and Disability
- Pediatric health and respiratory diseases
- Chronic Disease Management Strategies
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Diabetes Management and Education
- Nosocomial Infections in ICU
- Nutrition and Health in Aging
- Polyomavirus and related diseases
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Neonatal Respiratory Health Research
- Health and Lifestyle Studies
- Inflammation biomarkers and pathways
- Asthma and respiratory diseases
- Anesthesia and Sedative Agents
- Mobile Health and mHealth Applications
- Hemodynamic Monitoring and Therapy
- Olfactory and Sensory Function Studies
- DNA Repair Mechanisms
The University of Texas Medical Branch at Galveston
2013-2025
Baylor College of Medicine
2017-2019
Galveston College
1995-2019
Texas Children's Hospital
2018
SleepMed
2018
Children's Nutrition Research Center at Baylor College of Medicine
2017
The University of Texas Health Science Center at Houston
2017
University of Houston
2017
Universidad Cooperativa de Colombia
2013
Shriners Hospitals for Children - Galveston
1995-2006
Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine biological role of these DGs, null animal models have been generated. Here, we report generation and characterization mice lacking Neil2 (Nei-like 2). As in deficient each other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, NEIL3), Neil2-null show no overt phenotype....
Objective To evaluate the safety and efficacy of partial liquid ventilation (PLV) in adult patients with acute respiratory distress syndrome (ARDS). Summary Background Data Previous studies have evaluated gas exchange PLV severe failure whose was partially provided by extracorporeal life support (ECLS). This is first experience who were not on ECLS. Methods Intratracheal perflubron a total dose 30.1 ± 7.1 ml/kg administered over period 45 9 hours to nine mean age = 49 4 years PaO2/FiO2 ratio...
The selection and administration of neuromuscular blocking (NMB) drugs in intensive care unit (ICU) patients remain controversial.We compared the dose-response recovery pharmacodynamics a new intermediate-acting NMB drug, cisatracurium besylate, to vecuronium (VEC), prospective, randomized, double-blind, multicenter study critically ill adults. After informed consent, 58 mechanically ventilated ICU from five medical centers were randomized receive either or VEC. Fifty-four received before...
Objectives To determine whether changes in cardiac output, regional blood flow, and intracranial pressure during permissive hypercapnia are pH-dependent can be attenuated by correction of intravascular acidemia. Design Prospective, controlled study. Setting Research laboratory. Subjects Female Marino ewes. Interventions Animals were instrumented with a pulmonary artery catheter, femoral arterial venous catheters, catheter the third cerebral ventricle, ultrasonic flow probes on left carotid,...
Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent systemic inflammation. Anti-inflammatory therapies have been shown to decrease acute exacerbations of COPD. The antidiabetic medication metformin decreases oxidative stress and inflammation may benefit patients We aimed at investigating the effect on health care utilizations in coexisting COPD diabetes mellitus (DM). Methods: studied 5% Medicare beneficiaries DM prescribed or other antidiabetics during...
Abstract SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces genome activates DNA pathways. To test whether the compromised repair capacity individuals modulates severity infection, we analyze gene expression publicly available patient datasets observe a lower level glycosylase NEIL2 lungs severely infected patients. This observation levels is further validated patients, hamsters...
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in United States. Acute exacerbations COPD account for up to 84% total economic cost this disease. The altered mechanics patient represent a unique challenge clinician instituting assisted ventilation population. We developed an alternative mode limited extracorporeal support termed Venovenous carbon dioxide removal (VVCO2R). report our first case using VVCO2R, 42-year-old white woman with history and asthma,...
Purpose The purpose of the study was to evaluate feasibility integrating Community Health Workers (CHWs) as part team leading diabetes group visits. Methods This a randomized controlled that integrated CHWs visits for low-income Hispanic adults (n = 50). Group met 3 hours each month 6-month duration. Main measures included baseline and clinical outcomes (ie, A1C, lipids), concordance with 8 standard care guidelines screens cervical, breast, colon cancer) from US Preventive Task Force...
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway that an independent risk factor for lung cancer. Reduction in NEIL2 function, DNA glycosylase involved repair during transcription, has been associated with increased incidence of malignancies humans. knockout mouse models have demonstrated inflammation and oxidative damage the lungs after exposure to insult, but data are lacking regarding function individuals COPD. We investigated whether levels transcribed genome...
Introduction/Objectives: Diabetes increases the risk of complications, especially for vulnerable populations. Our previous randomized clinical trial (RCT), TIME ( T elehealth-supported, I ntegrated Community Health Workers (CHWs), M edication access, group visit E ducation), showed efficacy CHW-led diabetes care. This study aimed to gather data on transitioning from trials practical implementation. Methods: We conducted a 12-month RCT at nonprofit community clinic using Consolidated...
Objectives To quantify CO2 removal using an extracorporeal low-resistance membrane gas exchanger placed in arteriovenous shunt and evaluate its effects on the reduction of ventilatory volumes airway pressures during severe respiratory failure induced by smoke inhalation injury. Design Prospective study. Setting Research laboratory. Subjects Adult female sheep (n = 5). Interventions Animals were instrumented with femoral pulmonary arterial catheters underwent LD50 cotton injury via a...
Allergic asthma is characterized by airway eosinophilia, increased mucin production and allergen-specific IgE. Fc gamma receptor IIb (FcgammaRIIb), an inhibitory IgG receptor, has recently emerged as a negative regulator of allergic diseases like anaphylaxis rhinitis. However, no studies to date have evaluated its role in asthma. Our main objective was study the FcgammaRIIb lung inflammation. We used murine model Inflammation quantified BAL inflammatory cells production. expression measured...
Vasoactive drugs are routinely used in critically ill patients with shock to optimize the hemodynamic state while evaluating and treating potentially reversible causes. Limited data exist on use of multiple vasoactive intensive care unit. We hypothesize that 3 or more is associated worse outcomes.We retrospectively examined outcome patients, at least 18 years age, whom were administered simultaneously. included admitted between November 2007 August 2009. dopamine, dobutamine, epinephrine,...
Aberrant or constitutive activation of nuclear factor kappa B (NF-κB) contributes to various human inflammatory diseases and malignancies via the upregulation genes involved in cell proliferation, survival, angiogenesis, inflammation, metastasis. Thus, inhibition NF-κB signaling has potential for therapeutic applications cancer diseases. We reported previously that Nei-like DNA glycosylase 2 (NEIL2), a mammalian glycosylase, is preferential repair oxidized bases from transcriptionally active...
Extracorporeal CO2 removal may reduce minute ventilation requirements and allow for better tolerance of low tidal volume ventilating strategies in patients with severe respiratory insufficiency. Conventional extracorporeal gas exchange is labor-intensive, expensive, usually requires systemic anticoagulation. In this study, a simplified venovenous circuit was developed by using regional citrate anticoagulation to avoid potential complications associated heparin. Five healthy adult sheep...
Journal Article High-Frequency Percussive Ventilation With Systemic Heparin Improves Short-Term Survival in a LD100 Sheep Model of Acute Respiratory Distress Syndrome Get access Dongfang Wang, MD, PhD, PhD *Department Surgery, Shriners Hospitals for Children and University Texas Medical Branch, Galveston Search other works by this author on: Oxford Academic Google Scholar Joseph B. Zwischenberger, MD Galveston†Department Medicine, **Address reprint requests to Dr. Division Cardiothoracic...
Arteriovenous carbon dioxide removal (AVCO2R) has been shown to achieve total (CO2) exchange. To determine optimal blood and gas flow parameters that can provide maximal exchange evaluate the utility of AVCO2R at reduced flow, authors used a low resistance membrane exchanger within an arteriovenous shunt in mechanically ventilated sheep. Adult female sheep (n = 5) were anesthetized underwent placement device simple created between carotid artery common jugular vein. CO2 was determined as...
Background: Diabetes is a major contributor to morbidity and mortality. Community Health Workers (CHWs) have been instrumental in improving patient outcomes. However, CHW training largely focuses on general diabetes concepts rather than medications. Providing accessible, medication for CHWs has the potential increase understanding, personalized care, adherence, thereby Objective: To evaluate impact of telehealth-based outcomes as measured by HbA1c changes. Methods: We provided 12-month...