A5073353122- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- DNA Repair Mechanisms
- Sepsis Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Regulation of Appetite and Obesity
- RNA and protein synthesis mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Phagocytosis and Immune Regulation
- Thermal Regulation in Medicine
- Hormonal Regulation and Hypertension
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- Advanced Image and Video Retrieval Techniques
- RNA Research and Splicing
- Advanced Numerical Analysis Techniques
- Pharmacogenetics and Drug Metabolism
- Adipose Tissue and Metabolism
- Face and Expression Recognition
- Heat shock proteins research
- Fractional Differential Equations Solutions
- Biofuel production and bioconversion
Feinstein Institute for Medical Research
2014-2025
City of Hope
2003-2025
Beckman Research Institute
2012-2025
East China University of Science and Technology
2015-2025
Macau University of Science and Technology
2025
Xiangya Hospital Central South University
2025
Central South University
2025
Baylor University Medical Center
2025
Cancer Genetics (United States)
2016-2024
Nanjing Drum Tower Hospital
2023-2024
Codon usage biases are found in all eukaryotic and prokaryotic genomes, preferred codons more frequently used highly expressed genes. The effects of codon on gene expression were previously thought to be mainly mediated by its impacts translation. Here, we show that strongly correlates with both protein mRNA levels genome-wide the filamentous fungus Neurospora Gene optimization also results strong up-regulation RNA levels, suggesting is an important determinant expression. Surprisingly,...
Curcumin, the phytochemical component in turmeric, is used as a dietary spice and topical ointment for treatment of inflammation India centuries. Curcumin (diferuloylmethane) relatively insoluble water, but dissolves acetone, dimethylsulphoxide, ethanol. Commercial grade curcumin contains 10-20% curcuminoids, desmethoxycurcumin, bisdesmethoxycurcumin they are effective pure curcumin. Based on number clinical studies carcinogenesis, daily oral dose 3.6 g has been efficacious colorectal cancer...
Our study has shown that plasma levels of ghrelin, a stomach-derived peptide, are significantly reduced in sepsis, and ghrelin administration improves organ blood flow via nuclear factor (NF)-kappaB-dependent pathway. However, it remains unknown whether any protective effects on severe sepsis-induced acute lung injury (ALI) and, if so, inhibition NF-kappaB plays role it.To test the hypothesis reduces ALI mortality through NF-kappaB.Sepsis was induced rats by cecal ligation puncture (CLP)....
To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation.Ghrelin has been demonstrated to possess multiple functions, including stimulation vagus nerve. Our recent study shown plasma levels were significantly reduced sepsis; and improved organ perfusion function. However, it remained unknown whether also decreases proinflammatory cytokines and, if so, down-regulatory effect is mediated by activation nerve.Male rats...
Although phytochemical curcumin has been shown to possess anti-inflammatory properties, it remains unknown whether this agent any beneficial effects in sepsis. The purpose of study was demonstrate protects septic animals and, if so, activation peroxisome proliferator-activated receptor (PPAR)-gamma, an nuclear receptor, plays role.Prospective, controlled, and randomized animal study.A research institute laboratory.Male Sprague-Dawley rats.A bolus injection 0.2 micromol given intravenously...
Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or respiratory distress syndrome (ARDS). Mouse B-1a cells a phenotypically functionally unique sub-population of B cells, providing immediate protection against infection releasing natural antibodies immunomodulatory molecules. We hypothesize that ameliorate sepsis-induced ALI. was induced in C57BL/6 mice cecal ligation puncture (CLP). PBS were adoptively transferred into the septic intraperitoneally. After 20 h CLP,...
Sepsis refers to severe systemic inflammation leading acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by immune reactive cells, plays deleterious role various inflammatory diseases. However, its ALI caused sepsis remains unexplored. We hypothesize that treatment with an OPN-neutralizing antibody (anti-OPN Ab) protects mice against during sepsis.Sepsis was induced 8-week-old male C57BL/6 cecal...
Synonymous codons are not used with equal frequencies in most genomes. Codon usage has been proposed to play a role regulating translation kinetics and co-translational protein folding. The relationship between codon structures the vivo of eukaryotic folding is clear. Here, we show that there strong bias filamentous fungus Neurospora. Importantly, found genome-wide correlations choices predicted secondary structures: Nonoptimal preferentially intrinsically disordered regions, more optimal...
The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC) development. methyltransferases and the readers that transduce histone codes have been defined. However, whether demethylation actively occurs in cells what enzyme demethylates methylarginine residues various processes are unknown. We report JMJD1B, previously identified as a lysine demethylase for H3K9me2, mediates H4R3me2s its intermediate,...
Equatorial organization of myosin II and actin has been recognized as a universal event in cytokinesis animal cells. Current models for the formation equatorial cortex favor either directional cortical transport toward equator or localized de novo assembly. However, this process never analyzed directly dividing mammalian cells at high resolution. Here we applied total internal reflection fluorescence microscope (TIRF-M), coupled with spatial temporal image correlation spectroscopy (STICS)...
Milk fat globule epidermal growth factor 8 (MFG-E8) is a potent opsonin for the clearance of apoptotic cells and produced by mononuclear immune competent organs including spleen lungs. It attenuates chronic acute inflammation such as autoimmune glomerulonephritis bacterial sepsis enhancing cell clearance. Ischemia-reperfusion (I/R) injury gut results in severe inflammation, apoptosis, remote organ damage, lung (ALI).To determine whether MFG-E8 intestinal pulmonary after I/R.Wild-type (WT)...
The pathogenesis of stroke involves inflammation, apoptosis, and excitotoxicity, which is mediated in part by neuronal NO synthase (nNOS) activation. Ghrelin, an endogenous 28-amino acid peptide, shown to exert antiapoptotic anti-inflammatory properties. However, the effect ghrelin permanent focal cerebral ischemia role vagus nerve its action remain unknown. To study this, male adult Sprague-Dawley rats underwent right-sided middle artery occlusion (MCAO) with or without prior bilateral...