A5050476970- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Respiratory viral infections research
- Virus-based gene therapy research
- Antimicrobial Resistance in Staphylococcus
- Congenital Anomalies and Fetal Surgery
- Palliative Care and End-of-Life Issues
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Long-Term Effects of COVID-19
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- Tumors and Oncological Cases
- Cerebral Venous Sinus Thrombosis
- Ethics and Legal Issues in Pediatric Healthcare
- Tracheal and airway disorders
- Congenital heart defects research
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Bacteriophages and microbial interactions
- Congenital Diaphragmatic Hernia Studies
- Infectious Encephalopathies and Encephalitis
- Bone Tumor Diagnosis and Treatments
- Kawasaki Disease and Coronary Complications
Sapporo Medical University
2015-2025
Japan Pediatric Society
2017-2024
Asahikawa Medical University
2021
Kanagawa Children's Medical Center
2021
Hakodate National Hospital
2021
Hokushin General Hospital
2017
Japanese Red Cross Kanazawa Hospital
2017
National Institute of Technology, Tomakomai College
2017
National Institute of Infectious Diseases
2017
Muroran Institute of Technology
2017
Abstract Human adenovirus (HAdV) infections present diverse clinical manifestations upon infecting individuals, with respiratory predominating in children. We surveyed pediatric hospitalizations due to HAdV across 18 hospitals Hokkaido Prefecture, Japan, from July 2019 March 2024, recording 473 admissions. While remained below five cases per week September 2023, a notable surge occurred late October weekly admissions peaking at 15−20 November December. There were dramatic shifts the age...
During March-July 2014, rotavirus G8P[8] emerged as the predominant cause of gastroenteritis among children in Hokkaido Prefecture, Japan. Clinical characteristics were similar for infections caused by G8 and non-G8 strains. Sequence phylogenetic analyses suggest strains generated multiple reassortment events between DS-1-like P[8] bovine from Asia.
Rotavirus (RV) vaccination has been available in Japan since November 2011, but is not yet part of Japan's national immunisation programs. There are insufficient data on vaccine effectiveness (VE) among Japanese children.Between the months January and May 2014 2015, we conducted active surveillance gastroenteritis children at 14 medical facilities. Rectal swabs from all patients with diarrhoea or vomiting were tested for RV by immunochromatography, positive specimens genotyped. Demographic...
Favipiravir was initially developed as an antiviral drug against influenza and is currently used in clinical trials severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19). This agent presumably involved RNA chain termination during virus replication, although the molecular interactions underlying its potential impact on coronaviruses including SARS-CoV-2, SARS-CoV, Middle East coronavirus (MERS-CoV) remain unclear. We performed silico studies to elucidate detailed...
Human sapovirus (HuSaV) is a significant cause of gastroenteritis. This study aims to analyze the evolutionary dynamics RNA-dependent RNA polymerase (RdRp) and capsid (VP1) genes HuSaV GI.1 GI.2 genotypes between 1976 2020. Using bioinformatics tools such as Bayesian phylogenetics software BEAST 2 package (v.2.7.6), we constructed time-scale trees based on gene sequences. Most recent common ancestors (MRCAs) RdRp region VP1 in present diverged around 1930 1933, respectively. The were divided...
Review Reinfection Mechanisms of Various Viruses and Their Societal Implications Ryusuke Kimura 1,2,†, Yuriko Hayashi 3,†, Yuka Sato-Fujimoto 4, Kei Miyakawa 5, Kazuya Shirato 6, Koo Nagasawa 7, Fuminori Mizukoshi Takeshi Tsugawa 8, Akihide Ryo 4 Hirokazu 2,3,* 1 Department Bacteriology, Graduate School Medicine, Gunma University, Maebashi-shi 371-8511, Gunma, Japan 2 Advanced Medical Science Research Center, Paz Takasaki-shi 370-0006, 3 Health Science, Sciences, Faculty Healthcare, Tokyo...
Background: Podocytes are essential for kidney function, and their dysfunction can result in nephrotic syndrome, such as minimal change disease (MCD). Oxidative stress contributes to podocyte damage. We investigated the therapeutic potential of intravenously infused mesenchymal stem cells (MSCs) a puromycin aminonucleoside (PAN)-induced rodent MCD model, focusing on oxidative modulation. Methods: Sprague-Dawley rats were divided into three groups: intact, PAN-Vehicle, PAN-MSC. was induced...
Although significant clinical efficacy and safety of rotavirus vaccines were recently revealed in many countries, the mechanism their attenuation is not well understood. We passaged serially a cell culture-adapted murine EB strain mouse pups or cultures alternately repeatedly fully sequenced all 11 genes 21 virus samples mice cultures. Sequence analysis that mouse-passaged viruses regained virulence almost consistently acquired four kinds amino acid (aa) substitutions VP4 substitution aa 37...
Background: The clinical features of coronavirus disease 2019 (COVID-19) in children have been changing because the emergence and rapid spread variants concern (VOC). increase cases infected with VOC has brought persistent symptoms after COVID-19 children. This survey aimed to analyze manifestations pediatric Japan. Methods: We analyzed reported between February 2020 April 2022 Japan, using a dedicated database updated voluntarily by members Japan Pediatric Society. Using same database, we...
Many reports have reported a reduction in respiratory infectious diseases and gastroenteritis immediately after the coronavirus disease 2019 (COVID-19) pandemic, but data continuing into 2022 are very limited. We sought to understand current situation of various among children Japan as July improve public health post-COVID-19 era.We collected on hospitalized with 18 hospitals from June 2022.In total, 3417 patients were during study period. Respiratory syncytial virus decreased drastically...
Since 2013, equine-like G3 rotavirus (eG3) strains have been detected throughout the world, including in Japan, and were found to be dominant some countries. In 2016, first eG3 outbreak Japan occurred Tomakomai, Hokkaido prefecture, became other areas following year. There no significant differences clinical characteristics of non-eG3 infections. The across 2 years from 2016 2017 had DS-1-like constellations (i.e. G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2), genes highly conserved (97.5-100 %). One...
DNA gyrase plays important roles in genome replication various bacteria, including Pseudomonasaeruginosa. The gyrA gene encodes the subunit A protein (GyrA). Mutations GyrA are associated with resistance to quinolone-based antibiotics. We performed a detailed molecular evolutionary analyses of and quinolone drug, ciprofloxacin, using bioinformatics techniques. produced an phylogenetic tree Bayesian Markov Chain Monte Carlo (MCMC) method. This indicated that common ancestor was present over...
Abstract Following the coronavirus disease 2019 (COVID‐19) outbreak in February 2020, incidences of various infectious diseases decreased notably Hokkaido Prefecture, Japan. However, Japan began gradually easing COVID‐19 infection control measures 2022. Here, we conducted a survey children hospitalized with human metapneumovirus (hMPV), influenza A and B, respiratory syncytial virus infections 18 hospitals across Japan, spanning from July to June 2023. From March 2020 2022 (28 months), only...
ABSTRACT Norovirus (NV) is an important cause of acute nonbacterial gastroenteritis worldwide. Recently, several sporadic cases due to naturally occurring recombinant NVs have been reported. In January 2000, there was outbreak in infant home Sapporo, Japan. Of 34 residents the that were less than 2 years old, 23 developed gastrointestinal symptoms and NV infection confirmed by conventional reverse transcription-PCR detect RNA polymerase region genogroup II NV. this virus, shared 86%...
Rotavirus (RV) A is a very common cause of acute diarrhoea in infants and young children worldwide. Most human strains are classified into two major Wa-like DS-1-like genotype constellations, whilst minor third strain, AU-1, was described 1989 among RV isolates from Japan. AU-1 demonstrates high degree homology to feline RV, FRV-1, which suggests interspecies transmission RV. However, there has been no subsequent report RVs possessing the throughout all 11 genes genome. Between March 1997...
Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route gastroenteritis. In this study, we investigated very mild NoV adults (medical staff) who do not visit outpatient clinic and child outpatients. We also evaluated genotype differences between children possible routes during 5 years. number positives were...
Several publications concerning the methods of real-time PCR for human parvovirus B19 (B19V) have appeared and some case reports mention B19V DNA loads. However, no large-scale study quantitating levels in common or representative manifestations such as erythema infectiosum aplastic crisis has been performed. Consequently, using TaqMan assay, load a large sample subjects with was quantitated. Sixty-five acute phase were involved, addition 22 serum samples from seven B19V-associated...
To analyse the epidemiology of intussusception in Hokkaido Prefecture, Japan during a 10-year period spanning introduction rotavirus (RV) vaccine (2007-2016).Using standard questionnaire, retrospective surveillance was conducted across 17 hospitals with paediatric beds Prefecture. We compared data between pre-vaccine era (2007-2011) and post-vaccine (2012-2016).In total, 208 110 cases were pre- eras, respectively. A significant reduction incidence children aged <1 year observed from to...