A5060485140- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- Fuel Cells and Related Materials
- Cell death mechanisms and regulation
- Neuroendocrine Tumor Research Advances
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- RNA Interference and Gene Delivery
- Electrocatalysts for Energy Conversion
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Pain Mechanisms and Treatments
- Pancreatic function and diabetes
- Motor Control and Adaptation
- Pain Management and Placebo Effect
- Action Observation and Synchronization
- Viral gastroenteritis research and epidemiology
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Advancements in Solid Oxide Fuel Cells
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
Mie Chuo Medical Center
2008-2023
Alpha Medical (Slovakia)
2010-2023
Fujita Animal Hospital
2021-2023
National Hospital Organization
2008-2022
Nagasaki Medical Center
2001-2021
Showa University
1998-2018
Tokyo Ariake University of Medical and Health Sciences
2012-2018
University of Health Science
2018
Tokyo Metropolitan Children's Medical Center
1987-2015
Mie University
1989-2014
atic duct and diffuse enlargement of the entire pancreas due to lymphocyte infiltration.In 1995, Japanese investigators 3 firstly proposed a concept "autoimmune pancreatitis (AIP)", in which patients showed diffusely enlarged pancreas, narrowing pancreatogram, increased serum IgG, presence autoantibodies, fibrotic changes with lymphocytic infiltration steroidal efficacy.Thereafter, many AIP cases have been reported from Japan, has accepted as new clinical entity. 4,5The histopathological...
The bcl-2 gene is expressed in many types of human tumours and becomes transcriptionally deregulated the majority non-Hodgkin's lymphomas as result t(14;18) chromosomal translocations. 26-kDa Bcl-2 protein has been shown to block programmed cell death (apoptosis) induced by stimuli, including a wide variety chemotherapeutic drugs radiation. presence tumor cells correlated with poor responses therapy patients some cancer. To explore further relevance drug resistance, we used antisense (As)...
The bcl-2 gene can potentially encode 26- and 22-kDa proteins that differ only in their carboxyl tails because of an alternative splicing mechanism. larger these contains a hydrophobic transmembrane domain within its terminus, resides (at least part) mitochondrial membranes has been shown to prolong cell survival by blocking programmed death (also termed apoptosis). To explore the function shorter Bcl-2 protein lacks domain, DNAs encoding p26-Bcl-2-alpha or p22-Bcl-2-beta were expressed...
As the patients with autoimmune pancreatitis (AIP) are increasing in Japan, practical guideline for managing AIP is required to be established.Three committees (the professional committee making clinical questions [CQs] and statements by Japanese specialists, expert panelist rating modified Delphi method, evaluating moderators) were organized. Fifteen specialists extracted specific from a total of 871 literatures PubMed search (approximately 1963-2008) secondary database made CQs statements....
Objective: The aim of this study was to estimate the number autoimmune pancreatitis (AIP) patients in Japan and evaluate influence steroid therapy on course diabetes mellitus (DM) AIP. Methods: A total 2972 departments were randomly selected with hospital stratification throughout Japan. We sent a questionnaire asking report who had visited their 2002 fulfilled diagnostic criteria for AIP set by Pancreas Society. then second details clinical DM, if any, treatments used Results: annual...
Rapid eye movement sleep behaviour disorder (RBD) may serve as a useful indicator to approach Parkinson’s disease (PD); however, PD patients do not always exhibit RBD. We wondered whether the presence of RBD would be reflected in expansion lesions and represent same entity. examined clinical differences between with without studied frequency RBD-like symptoms (RBD-s) 150 patients, including 81 (54.0%) who satisfied <i>International Classification Sleep Disorders, Revised,</i>...
We used fMRI to study the human imitation of hand/arm postures and finger configuration, subjects imitated in hand condition, they configurations condition. Compared with control only condition showed significant activation Broca's area symmetrical bilateral inferior parietal lobes, while left lateralised superior pattern. Our findings suggest that might be involved more configuration than postures. The result patterns was fully consistent formerly reported clinical findings, relationship...
Expression of the bcl-2 gene becomes deregulated in many non-Hodgkin lymphomas as result t(14;18) chromosomal translocations. Because regulates survival cells, and because its over-expression is associated with cellular resistance to killing by chemotherapeutic drugs γ-irradiation, this mRNA protein products represent ideal targets for designing novel therapeutic strategies treatment cancer. Here we describe effects an 18-mer phosphodiester oligonucleotide that complementary first 6 codons...
Rett syndrome (RTT) is a major neurodevelopmental disorder, characterized by mental retardation and autistic behavior. Mutation of the MeCP2 gene, encoding methyl CpG-binding protein 2, causes disease. The pathomechanism which dysfunction leads to RTT phenotype has not been elucidated. We found that directly regulates expression insulin-like growth factor binding 3 (IGFBP3) gene in human mouse brains. A chromatin immunoprecipitation assay showed IGFBP3 promoter contained an site....
The emergence and rapid spread of novel DS‐1‐like intergenogroup reassortant rotaviruses having the equine‐like G3 genotype (DS‐1‐like G3P[8] strains) have been recently reported from several countries. During rotavirus surveillance in Japan 2015–2016, three strains were identified children with severe diarrhea. In present study, we sequenced characterized full genomes these strains. On full‐genomic analysis, all showed a unique constellation including both genogroup 1 2 genes:...
WE tried to identify the mechanisms directly related syntactic processing in an fMRI experiment using strictly controlled sets of verbal stimuli. In two conditions, center-embedding and left-branching same words were used construct stimulus sentences, while only word order reflecting their structure was different. The subject's task understand relationship among three characters mentioned sentences. A difference activation Broca's area (BA44 45) between conditions found. This result suggests...
Imitation plays a very important role in human cognition. Because previous neuroimaging studies on imitation used rather simple actions as target stimuli, some aspects of such perceiving or manipulating one's own mental image could not be studied. We complicated non-symbolic (S−) and symbolic (S+) finger configurations stimuli order to study the neural substrates involved perception manipulation during imitation. Bilateral supramarginal gyrus activation was detected when S− condition...
Real-time scanning was applied to the sonically guided puncture technique. A special attachment connected ultrasound sector scanner developed for this purpose. needle is introduced into plane through canal in attachment. Excellent real-time images of both target lesion and can be clearly seen on oscilloscope during procedure. Puncture not only cystic structures but also solid masses made easily safely by new Successful applications technique have been carried out renal cyst puncture,...