A5063890462- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Microbial infections and disease research
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Pediatric Urology and Nephrology Studies
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Atomic and Molecular Physics
- Gastric Cancer Management and Outcomes
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Tracheal and airway disorders
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
Kawasaki Medical School
2017-2025
Comer Children's Hospital
2023
Niigata University Medical and Dental Hospital
2011-2017
Okayama Prefecture
2017
Niigata University
2011-2016
Saiseikai Niigata Daini Hospital
2015
University of California, San Diego
2015
Associated Press
2015
Niigata Prefectural Shibata Hospital
2009-2011
Shizuoka Prefecture Agricultural and Forestry Research Institute
2010
Mycoplasma pneumoniae is a common cause of respiratory tract infections with community-acquired pneumonia as the major disease-related burden. Compared other pathogens, M atypical in many ways: it one smallest self-replicating organisms, has reduced and highly stable genome (0·8 Mbp), lacks cell wall, grows slowly (generation time 6 h), requires close contact for transmission, distinct disease presentation (atypical pneumonia), pathogenesis which might involve host cell-mediated...
ABSTRACT Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was collected from children with bullous impetigo in 2003 and 2004. One strain Panton-Valentine leucocidin (PVL) positive. In 2004, a multiple-drug-resistant PVL + CA-MRSA isolated an athlete cutaneous abscess. These strains were analyzed by multilocus sequence typing, spa agr coagulase staphylococcal cassette chromosome mec (SCC ) PCR assay for 30 virulence genes, drug susceptibility testing, pulsed-field gel...
We evaluated isolates obtained from children with Mycoplasma pneumoniae infection throughout Japan during 2008-2015. The highest prevalence of macrolide-resistant M. was 81.6% in 2012, followed by 59.3% 2014 and 43.6% 2015. among has decreased.
Human parechovirus type 3 (HPeV3) is an emerging pathogen that causes sepsis and meningoencephalitis in young infants. To test the hypothesis maternal antibodies can protect this population, we measured neutralizing antibody titers (NATs) to HPeV3 other genotypes (HPeV1 HPeV6) 175 cord blood samples Japan. The seropositivity rate (≥1:32) for was 61%, similar genotypes, but decreased significantly as age increased (p<0.001). Furthermore, during 2014 epidemic, prospective measurement of NATs...
For the first time, we synthesized multiple embedded polar groups (EPGs) containing linear C18 organic phases. The new materials were characterized by elemental analysis, IR spectroscopy, (1)H NMR, diffuse reflectance infrared Fourier transform (DRIFT), solid-state (13)C cross-polarization magic angle spinning (CP/MAS) suspended-state and differential scanning calorimetry (DSC). (29)Si CP/MAS NMR was carried out to investigate degree of cross-linking silane functionality modified silica....
The rise of macrolide-resistant Mycoplasma pneumoniae (MRMP), marked by point mutations in the 23S rRNA gene, poses a growing global concern since its initial detection 2001. prominence A2063G mutation during this emergence remains unexplained. This study aimed to clarify possibility detecting MRMP from recent clinical macrolide-susceptible M. through exposure azithromycin (AZM), which has long half-life and was launched immediately before first detection. Six strains isolated Japanese...
Abstract Background Baloxavir marboxil (baloxavir) is a new anti-influenza drug that works as cap-dependent endonuclease inhibitor. It approved for prophylactic use against influenza in Japan, but there are few reports on this usage hospitalized in-patients. reportedly reduces patient susceptibility to through mechanism involving amino acid substitution. Methods Between August 2023 and July 2024, we investigated the efficacy of baloxavir among in-patients at our hospital who had close...
Molecular typing of Mycoplasma pneumoniae is an important tool for identifying grouped cases and investigating outbreaks. In the present study, we developed a new genotyping method based on single nucleotide polymorphisms (SNPs) selected from whole-genome sequencing eight M. strains, using SNaPshot minisequencing assay. Eight SNPs, localized in housekeeping genes, predicted lipoproteins, adhesin P1 genes were genotyping. These SNPs evaluated 140 clinical isolates previously genotyped by...
IntroductionMycoplasma pneumoniae contributes to numerous pneumonia cases among children and young adults. Therefore, this study aimed investigate the prevalence of M. infections Japanese children, occurring since 2008.MethodsNasopharyngeal swab specimens were obtained from all cases, following which real-time PCR was performed identify pneumoniae. Further, p1 genotypes isolates determined using restriction fragment length polymorphism typing method.ResultsThe annual rate macrolide-resistant...
Group B Streptococcus (GBS) is one of the leading causes neonatal bacterial infections. Population-based surveillance GBS-related invasive diseases among newborns and infants from 10 prefectures in Japan was performed between 2007 2012. The characteristics cases isolated GBS are described this study. incidence rate 0.13 per 1,000 live births. Analysis samples obtained 60 showed that most frequent serotypes were III (48.3%), Ia (30.0%), Ib (10.0%). All isolates susceptible to penicillin G,...
We characterized 118 Mycoplasma pneumoniae strains isolated from three areas of Japan (Saitama, Kanagawa, and Osaka) during the period 2019 2020. Genotyping p1 gene in these revealed that 29 them were type 1 lineage (29/118, 24.6%), while 89 2 (89/118, 75.4%), thereby indicating was dominant this period. The most prevalent variant 2c (57/89, 64%), second-most 2j, a novel identified study (30/89, 33.7%). Type 2j is similar to g , but cannot be distinguished reference (classical 2) using...
Loop-mediated isothermal amplification (LAMP) is a cost-effective and rapid method for identifying Mycoplasma pneumoniae (MP). We investigated the utility of LAMP assay in diagnosing MP pneumonia among children clinical setting. In this prospective study, cause community-acquired was evaluated 111 patients whom suspected pathogen. All participants were at city hospital Japan between April 2012 September 2012. Throat swabs obtained admission, paired serum samples to measure antibody titres by...