A5101705690- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Neurological and metabolic disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
- Diabetes Management and Research
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Diet and metabolism studies
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Diabetes and associated disorders
- Clinical practice guidelines implementation
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Ovarian cancer diagnosis and treatment
- Protein Interaction Studies and Fluorescence Analysis
- Nutrition, Health and Food Behavior
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
- Photoreceptor and optogenetics research
Kitasato University
2016-2025
National Sagamihara Hospital
2018-2021
Niigata Institute of Technology
2018
Kawasaki Medical School
2016
Kitasato University Hospital
2014
Tohoku University
2000-2009
Chugoku Rosai Hospital
2008
Nagasaki University
2007
Tohoku University Hospital
2005
Waseda University
1998-2004
To date, evidence for long-term renoprotection with angiotensin receptor blockers (ARBs) has come almost exclusively from Caucasian patients (1–3), despite Japanese people being at high risk of diabetic nephropathy and very susceptible to end-stage renal disease (4–6). We conducted the INNOVATION Study (Incipient Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy) evaluate efficacy an ARB in preventing transition microalbuminuria overt (7). This study is...
The Joint Committee on Diabetic Nephropathy has revised its Classification of (Classification 2014) in line with the widespread use key concepts, such as estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). In revising Classification, carefully evaluated, relevant to current revision, report a study conducted by Research Group Nephropathy, Ministry Health, Labor Welfare Japan. Major revisions are summarized follows: (i) eGFR is substituted for GFR Classification;...
The expression of 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1 and 2 was examined immunohistochemically in 111 invasive ductal carcinomas, correlated with various clinicopathological parameters. This study investigates local regulatory mechanisms oestrogens human breast carcinoma. 17β-HSD immunolocalized carcinoma cells 68 out cases (61.3%). immunoreactivity not detected all examined. A significant inverse correlation observed between the immunohistochemical histological grade (P<...
The aim of the study was to determine transition rate and factors associated with progression normo- low microalbuminuria diabetic nephropathy (overt proteinuria). For 8 years we prospectively observed 1,558 Japanese patients type 2 diabetes mellitus whose basal urinary albumin:creatinine ratio (UACR) had been measured as <17.0 mg/mmol at entry. incidence (UACR >33.9 mg/mmol) determined by measuring UACR twice a year. Progression occurred in 74 patients. annual 0.67%, substantially higher...
It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) human breast. However, biological significance remains largely unclear situ (DCIS), regarded as a precursor lesion IDC, which partly due to fact intratumoral concentration has not been examined DCIS. Therefore, this study, we first concentrations estradiol and 5alpha-dihydrotestosterone (DHT) using liquid chromatography/electrospray tandem mass spectrometry Intratumoral both DHT were...
OBJECTIVE To examine the interactive relationship between diabetic retinopathy (DR) and nephropathy (DN) in type 2 patients to elucidate role of DR microalbuminuria on onset macroalbuminuria renal function decline. RESEARCH DESIGN AND METHODS We explored effects progression DN from normoalbuminuria low (&lt;150 mg/gCr) or decline Japan Diabetes Complications Study (JDCS), which is a nationwide randomized controlled study focusing lifestyle modification. Patients were divided into four...
Studies on the rate of remission macroalbuminuria in patients with type 2 diabetes mellitus (T2DM) and effects reduction albuminuria renal prognosis a primary care setting are absolutely lacking.A total 211 T2DM albuminuria≥300 mg/g were enrolled prospective observational study (mean 4.5 years). The incidence at every 1-year time point after starting intensified treatment factors associated evaluated. association events (doubling serum creatinine end-stage disease) was also...
Small cell carcinoma of the endometrium is extremely rare. Aim. We reported three cases this rare tumor and reviewed literature.Case 1 was a 54-year-old woman case 3 58-year-old woman. Both patients presented with vaginal bleeding. Case 2, 53-year-old woman, had no symptoms vaginal-cervical smear suspicious for malignancy. All underwent surgery their tumors originated in endometrium. In all cases, pathological examination revealed small endometrium, immunohistochemical reactivity one or more...
It has been reported that agonists of peroxisome proliferator-activated receptor γ (PPARγ) inhibit proliferation breast carcinoma cells, but the biological significance PPARγ remains undetermined in human carcinomas. Therefore, we immunolocalized 238 tissues. immunoreactivity was detected 42% carcinomas, and significantly associated with status estrogen (ER) α, ERβ, progesterone receptor, retinoic X receptors, p21 or p27, negatively correlated histological grade cyclooxygenase-2 status. an...
According to studies by the National Kidney Foundation and Food Drug Administration, 30% 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, benefits using these diabetic patients remain unclear.This cohort study comprised Japanese with type 2 diabetes; those repeated serum creatinine measurements during a baseline period years (n = 1868) or 3 2001) were enrolled. Subsequent risks ESRD following eGFR...
Background and objectives Renal histological injury patterns in type 2 diabetes are heterogeneous. We compared renal using biopsy findings with function followed up functional changes normoalbuminuric microalbuminuric patients to determine whether progresses according patterns. Design, setting, participants, measurements examined 111 percutaneous (78 men, 52±11 years old, 59 normoalbuminuria, 52 microalbuminuria) 37 cases for 11 years. Light microscopy of tissues revealed as: category I...
Human epithelial ovarian carcinoma is well-known as a sex steroid-dependent neoplasm, but the possible biological significance of progesterone receptor (PR) in this cancer remains controversial. Recently, two isoforms human PR, PRA and PRB, have been characterized different functional characteristics reported for these isoforms. We therefore examined immunohistochemistry (107 cases) reverse transcription-polymerase chain reaction (RT-PCR) (16 PRA, oestrogen receptor-a (ER-a). Labeling...