A5004453528- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- PARP inhibition in cancer therapy
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Genomics and Rare Diseases
- Plant and animal studies
- Chemotherapy-induced organ toxicity mitigation
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Insect and Arachnid Ecology and Behavior
- RNA modifications and cancer
Tohoku University
1998-2025
Tohoku University Hospital
2017-2025
The University of Tokyo
2000-2024
Center for Innovation
2023
Tohoku Medical Megabank Organization
2023
Tottori University
2012-2022
Sendai Medical Center
2019-2021
National Hospital Organization
2019-2021
Toyohashi Municipal Hospital
2019
Hyogo Prefectural Amagasaki General Medical Center
2012-2018
Pazopanib is an oral, multikinase inhibitor of vascular endothelial growth factor receptor (VEGFR) -1/-2/-3, platelet-derived (PDGFR) -α/-β, and c-Kit. Preclinical clinical studies support VEGFR PDGFR as targets for advanced ovarian cancer treatment. This study evaluated the role pazopanib maintenance therapy in patients with whose disease did not progress during first-line chemotherapy.Nine hundred forty histologically confirmed ovary, fallopian tube, or peritoneum, International Federation...
Abstract: Nedaplatin, a cisplatin analog, has been developed to decrease the toxicities induced by cisplatin, such as nephrotoxicity and gastrointestinal toxicity. The dose of nedaplatin is determined body surface area, not area under curve (AUC). recommended therapeutic 80–100 mg/m 2 , although pharmacokinetic profile similar that carboplatin. In our preliminary study, there was favorable correlation between AUC creatinine clearance (CL), suggesting renal function should be considered when...
To examine the association between surgical volume and survival of women with early-stage cervical cancer who underwent radical hysterectomy.This is a nationwide multicenter retrospective study examining consecutive clinical stage IB1-IIB hysterectomy pelvic lymphadenectomy from 2004 to 2008 (N=5,964). The per site over 5-year period was defined as low-volume (fewer than 32 surgeries, 46 [39.7%] institutions, n=649 [10.9%]), mid-volume (32-104 60 [51.7%] n=3,662 [61.4%]), high-volume (105...
Gastric-type mucinous carcinoma (GAS) is a novel variant of the uterine cervix, characterized by aggressive clinical behavior and absence high-risk human papillomavirus. We conducted this study to evaluate chemosensitivity GAS compared with that usual-type endocervical adenocarcinoma (UEA) in patients who had been enrolled our previous study.Of 52 from phase 2 (SGSG005) neoadjuvant chemotherapy docetaxel carboplatin for stage IB2 IIB nonsquamous cervical cancer, 47 (stage IB2, 12; IIA2, 7;...
This was a nation‐wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB–IIB cervical cancer with pelvic and/or para‐aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death patterns of disease were compared based upon the adjuvant treatment pattern: whole radiotherapy alone ( n = 253), concurrent chemoradiotherapy (CCRT, 502) chemotherapy 319). Women received had similar (5‐year rates, 36.6% vs . 34.1%,...
c‐erbB‐2 and c‐Met expression relates to cholangiocarcinogenesis progression of intrahepatic cholangiocarcinoma Aims : The proto‐oncogenes are important for tumour invasiveness metastasis in many types malignant tumours. Previous studies have indicated that these proteins associated with carcinogenesis cholangiocarcinoma. In this study, we examined by immunohistochemistry hepatolithiasis, metastatic lymph node, order clarify whether play a role Methods results the staining was positive 14 23...
Clear cell carcinoma (CCC) of the ovary has been recognized to show resistance anticancer agents in first-line chemotherapy. Our aim was evaluate effect second-line chemotherapy a retrospective study. A total 75 patients diagnosed with CCC and treated between 1992 2002 collaborating hospitals were reviewed. Criteria for patients' enrollment 1) diagnosis pure-type at initial operation, 2) treatment after one systemic postoperative chemotherapy, 3) measurable recurrent or refractory tumor, 4)...
Resistance of ovarian mucinous adenocarcinoma to standard chemotherapy with paclitaxel and carboplatin is associated poor prognosis, an effective treatment needed. The present study aimed identify for adenocarcinoma. Five human cell lines (MN-1, OMC-1, RMUG-L, RMUG-S, TU-OM-1) were used in this study. Sensitivity the cells anticancer agents was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, we assessed drug sensitivity calculating assay area under curve...
We investigated community-based data of the Mini-Mental State Examination (MMSE) scores elderly residents along with effects age and educational level. MMSE was planned for all over 65 years in a town northern Japan. The number elders who took 2,266 (90%). score significantly declined lower level, although no effect sex apparent. For subitems, values except that naming showed both Those screened by fell range cognitive impairment (< 24) accounted 21.8% those severe 18) constituted 6.0%....
The efficacy of radiotherapy (RT) for adenocarcinoma (AC) is controversial, although patients with AC the uterine cervix are treated in a similar manner to those squamous cell carcinoma (SCC). this retrospective study was conducted evaluate adjuvant RT compared SCC following radical hysterectomy. A total 820 stage IB‑IIB cervical cancer, who underwent type III hysterectomy between 1997 and 2003, were retrospectively examined; sample included 280 540 SCC. 139 327 treatment. histological did...
Objective The aim of this study was to determine the current operative management International Federation Gynecology and Obstetrics (FIGO) stage IB2, IIA2, IIB uterine cervical cancer (bulky tumors) in Japan by surveying member institutions Japanese Gynecologic Oncology Group. Methods We conducted a survey assess management, including indications treatment, at all 199 active Results A total 166 (83.4%) responded survey. For patients with squamous cell carcinoma, 35.5% (59/166) performed...
To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo dissection hysterectomy.This is a retrospective analysis nation-wide cohort study surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify independent metastasis/recurrence.There 120 (2.1%) cases surgery with parametrial involvement (adjusted odds ratio [aOR]=1.65), deep stromal...
The objective of this study was to assess the oncologic outcome surgically-treated patients with early-stage, intermediate-risk cervical cancer according postoperative therapy modality. This retrospective cohort queried Japanese Gynecologic Oncology Group's nationwide surgical data platform. population 1084 stage IB who underwent primary radical hysterectomy and lymphadenectomy from 2004 2008. Histology type-incorporated factor patterns were clustered into three groups based on recurrence...
1. In some overwintering insects, several authors have suggested a trade-off in the allocation of metabolic reserves between diapause maintenance and post-diapause reproduction. To investigate this trade-off, diapausing larvae bruchid Kytorhinus sharpianus were exposed to various periods chilling (5 °C) we examined changes egg production adult longevity after termination chilling. 2. A relatively long period during increased both incidence rate termination. 3. Long reduced production,...