A5011988426- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Ovarian function and disorders
- Uterine Myomas and Treatments
- T-cell and B-cell Immunology
- Endometriosis Research and Treatment
- Barrier Structure and Function Studies
- Pregnancy and preeclampsia studies
- Heat shock proteins research
- Maternal and fetal healthcare
- Reproductive Biology and Fertility
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Wnt/β-catenin signaling in development and cancer
- Ectopic Pregnancy Diagnosis and Management
- Cell Adhesion Molecules Research
- Cancer Risks and Factors
- Connexins and lens biology
- Ureteral procedures and complications
- Cancer Immunotherapy and Biomarkers
- Preterm Birth and Chorioamnionitis
Sapporo Medical University
2016-2025
Juntendo University
2024
Osaka University of Human Sciences
2024
Sapporo Medical University Hospital
2013-2023
Sapporo University
2017
Kushiro City General Hospital
2016
Hokkaido University
2007
Kyushu University
2001-2004
Muroran Institute of Technology
2002
Centre international de recherche sur le cancer
1997-2000
Gap-junction plaques are often observed with tight-junction strands of vascular endothelial cells but the molecular interaction and functional relationships between these two junctions remain obscure. We herein show that gap-junction proteins connexin40 (Cx40) Cx43 colocalized coprecipitated molecules occludin, claudin-5, ZO-1 in porcine blood-brain barrier (BBB) cells. Gap junction blockers 18beta-glycyrrhetinic acid (18beta-GA) oleamide (OA) did not influence expression Cx40, Cx43,...
Does administration of androgen to female-to-male transsexual persons (FTMs) reproductive age induce polycystic ovary (PCO) morphology?Administration high-dose women causes pathognomonic changes the ovarian cortex and stroma that resemble Stein-Leventhal syndrome but it does not PCO morphology.Androgen is thought play a key role in follicular development be involved pathophysiology (PCOS). In several experimental models, animals given show similar those with PCOS. previous human studies,...
Cancer stem-like cells (CSCs)/cancer-initiating (CICs) are defined as a small population of cancer that have high tumorigenicity. Furthermore, CSCs/CICs resistant to several therapies, and therefore thought be responsible for recurrence after treatment distant metastasis. In epithelial ovarian (EOC) cases, disease chemotherapy is frequently observed, suggesting involved. There four major histological subtypes in EOC, serous adenocarcinoma clear cell high-grade malignancies. We analyzed from...
There is no effective treatment for women with unexplained recurrent pregnancy loss (RPL). We aimed to investigate whether a high dose of intravenous immunoglobulin (IVIG) in early can improve outcomes RPL.In double-blind, randomised, placebo-controlled trial, primary RPL aetiology received 400 mg/kg IVIG daily or placebo five consecutive days starting at 4-6 weeks gestation. They had experienced four more miscarriages except biochemical and least one miscarriage normal chromosome karyotype....
Pulmonary surfactant protein D (SP-D), a member of the collectin group innate immune proteins, plays important roles in lipopolysaccharide (LPS) recognition. We have previously shown that A (SP-A), homologous collectin, interacts with Toll-like receptor (TLR) 2, resulting alteration TLR2-mediated signaling. In this study, we found natural and recombinant SP-Ds exhibited specific binding to extracellular domains soluble forms TLR2 (sTLR2) TLR4 (sTLR4). Binding was concentration-...
The aim of this study is to understand the relationship between polycystic ovary syndrome (PCOS), altered hormonal characteristics and insulin resistance in female-to-male (FTM) transsexual patients.We studied 69 Japanese FTM cases, aged 17-47 years, who were seen Gender Identity Disorder Clinic Sapporo Medical University Hospital December 2003 May 2006. subjects had never received treatment or sex re-assignment surgery. Prior treatment, they physical examinations entailing measurement...
Cancer stem-like cells (CSCs)/cancer-initiaiting (CICs) are defined as a small population of cancer that have self-renewal capacity, differentiation potential and high tumor-initiating ability. CSCs/CICs ovarian been isolated by side (SP) analysis, ALDEFLUOR assay using cell surface markers. However, these approaches not definitive markers for CSCs/CICs, it is necessary to refine recent methods identifying more highly purified CSCs/CICs. In this study, we analyzed SP aldehyde dehydrogenese...
Epithelial ovarian cancer (EOC) is one of the most deadly carcinomas in females. Immune systems can recognize EOCs; however, a defect human leukocyte antigen (HLA) class I expression known to be major mechanism for escape from immune systems, resulting poor prognosis. The purpose this study identify novel correlations between immunologic responses and other clinical factors. We investigated components 122 cases EOCs which surgical operations were performed 2001 2011. immunohistochemically...
Bone marrow-derived mesenchymal stem cells (BM-MSC) has been applied as the most valuable source of autologous cell transplantation for various diseases including diabetic complications. However, hyperglycemia may cause abnormalities in intrinsic BM-MSC which might lose sufficient therapeutic effects patients. We demonstrated functional derived from both type 1 and 2 diabetes models vitro, resulted loss vivo nephropathy (DN). Then, we developed a novel method to improve using human umbilical...
Abstract Recent studies have revealed that metabolic reprogramming is closely associated with epithelial‐mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) a key glycolytic enzyme highly expressed in several types of cancer. In this study, we found ALDOA uterine cervical adenocarcinoma and high expression promotes EMT to increase malignant potentials, such as metastasis invasiveness, cells. human surgical specimens, was correlated lymph node metastasis, lymphovascular...
We have previously shown that the connexin (Cx) 26 and 32 genes are expressed during secretory phase of human endometrium their expression is downregulated proliferative phase, suggesting a role for intercellular transduction in cell growth control endometrium. To further study possible cell-to-cell interaction regulation, we immunohistochemically analyzed 80 endometrial samples (30 normal endometrium, 20 hyperplasia, 30 cancer) E-cadherin; α-,β-, γ-catenin; adenomatous polyposis coli (APC)...
The immunohistochemical expression of β-catenin, cyclin D1, Ki-67 and PCNA was Examined in 38 cases sporadic extra-abdominal or abdominal-wall desmoid tumours without familial adenomatous polyposis (FAP), to evaluate the hypothesis that accumulated β-catenin within nuclei could affect regulation D1 gene. There a statistically significant correlation between accumulation overexpression (p=0.029). Each group with showed higher PCNA-LI than those without, difference being (p=0.007, p=0.004,...
We investigated the mechanism by which a GnRH agonist (GnRHa) affects ovarian vascularity, vascular permeability, and expression of tight junction protein claudin-5 in rat model hyperstimulation syndrome (OHSS). Hyperstimulated rats received excessive doses pregnant mare serum gonadotropin (PMSG; 50 IU/d) for 4 consecutive days, from d 25 to 28 life, followed IU human chorionic (hCG) on 29. Control 10 PMSG 27 hCG GnRHa (leuprolide 100 μg/kg·d) was administered some hyperstimulated either 29...
MicroRNA-34a (miR-34a) is associated with invasion and metastasis of various cancers. The trophoblastic cells placenta accreta invade into the myometrium in a similar way to We studied roles miR-34a pathogenesis accreta.The human choriocarcinoma cell line JAR was used for vitro experiments as model trophoblasts, placental tissues from operative specimen patients or without were vivo. Morpholino antisense oligomer against (miR-34a Morpho/AS) added JAR, expression plasminogen activator...
To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo dissection hysterectomy.This is a retrospective analysis nation-wide cohort study surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify independent metastasis/recurrence.There 120 (2.1%) cases surgery with parametrial involvement (adjusted odds ratio [aOR]=1.65), deep stromal...
Cervical cancer is a major cause of death in females worldwide. stem-like cells (CSCs)/cancer-initiating (CICs) are resistant to conventional radiotherapy and chemotherapy, CSCs/CICs thought be responsible for recurrence. Eradication thus essential cure cervical cancer. In this study, we isolated by sphere culture, identified testis (CT) antigen, CTCFL/BORIS, that expressed CSCs/CICs. BORIS has 23 mRNA isoform variants classified 6 subfamilies (sfs), they encode 17 different peptides. sf1...