A5043205342- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and related cancers
- Olfactory and Sensory Function Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Cancer Research and Treatments
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Iron Metabolism and Disorders
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Hematological disorders and diagnostics
- Bladder and Urothelial Cancer Treatments
Sapporo Medical University
2010-2024
Health Sciences University of Hokkaido
2021-2023
Otaru Municipal Hospital
2021-2022
Kushiro City General Hospital
2017
Hokkaido University
2007-2013
University Medical Center Groningen
2012
Wakayama Medical University
2012
Ehime University
2012
Sapporo University
2008
Hokkaido University Hospital
2005
Cancer stem-like cells (CSC) are a small population of cancer with superior tumor initiating, self-renewal, and differentiation properties. In this study, we show that the cancer-testis antigen HSP40 family member DNAJB8 contributes to CSC phenotype in renal cell carcinoma (RCC). overexpression increased percentage side (SP) representing CSCs RCC cells, enhancing their tumor-initiating ability. Conversely, attenuation decreased SP reduced The utility as an immunologic target was established...
Cancer stem-like cells (CSCs)/cancer-initiating (CICs) are defined as a small population of cancer that have high tumorigenicity. Furthermore, CSCs/CICs resistant to several therapies, and therefore thought be responsible for recurrence after treatment distant metastasis. In epithelial ovarian (EOC) cases, disease chemotherapy is frequently observed, suggesting involved. There four major histological subtypes in EOC, serous adenocarcinoma clear cell high-grade malignancies. We analyzed from...
Cancer-initiating cells (CICs) are thought to be essential for tumor maintenance, recurrence, and distant metastasis, they therefore reasonable targets cancer therapy. Cancer immunotherapy is a novel approach target cancer. In this study, we aimed establish CIC-targeting immunotherapy.Colorectal (CRC) CICs were isolated as side population (SP) cells. The gene expression profile of CRC was analyzed by cDNA microarray RT-PCR. Protein olfactory receptor family 7 subfamily C member 1 (OR7C1)...
Abstract Cancer/testis ( CT ) antigens encoded by genes are immunogenic antigens, and the expression of gene is strictly restricted to only testis among mature organs. Therefore, promising candidates for cancer immunotherapy. In a previous study, we identified novel antigen, DNAJB8 . was found be preferentially expressed in stem‐like cells CSCs )/cancer‐initiating CICs ), it thus CSC antigen. this hypothesized that / rather than non‐ /‐ examined The 74 evaluated side population SP (= main MP...
The aim of the present study was to establish cancer stem‐like cell/cancer‐initiating cell ( CSC / CIC )‐targeting immunotherapy. are thought be essential for tumor maintenance, recurrence and distant metastasis. Therefore they reasonable targets therapy. In study, we found that a heat shock protein HSP ) 40 family member, DnaJ (Hsp40) homolog, subfamily B, member 8 DNAJB 8), is preferentially expressed in derived from colorectal CRC cells rather than non‐ . Overexpression enhanced...
Cancer stem-like cells (CSCs)/cancer-initiaiting (CICs) are defined as a small population of cancer that have self-renewal capacity, differentiation potential and high tumor-initiating ability. CSCs/CICs ovarian been isolated by side (SP) analysis, ALDEFLUOR assay using cell surface markers. However, these approaches not definitive markers for CSCs/CICs, it is necessary to refine recent methods identifying more highly purified CSCs/CICs. In this study, we analyzed SP aldehyde dehydrogenese...
Adult T cell leukemia/lymphoma (ATL) is a highly aggressive malignancy, and has poor prognosis. Recently, allogeneic-hematopoietic stem transplantation (allo-HSCT) been suggested to improve the outcome. We retrospectively analyzed 15 patients with ATL who had received allo-HSCT in 2 institutions Hokkaido, Japan. The median age of was 57 years. estimated 3-year overall survival (OS) progression-free (PFS) rates were 73.3% 66.7%, respectively. Calcineurin inhibitor dosage reduced...
Hepatitis B virus (HBV)-reverse seroconversion (RS) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a frequent late-onset complication in recipients with previous HBV infection. We followed 38 allo-HSCT infection, and conducted posttransplant HB vaccine intervention 13 recipients. First, we the without any (historic control) until 2003; hence, commenced vaccination. Out of patients who underwent after 2003, were immunized by standard three-dose regimen...
Cancer stem cells (CSCs)/cancer-initiating (CICs) are characterized as a small population of cancer that have high tumor-initiating ability. CSCs/CICs resistant to several therapies, and eradication is essential cure cancer. How can we eradicate CSCs/CICs? Cytotoxic T lymphocytes (CTLs) might be promising answer.
Introduction Immune checkpoint inhibitors are now a standard therapeutic option for lung adenocarcinoma. However, often induce various immune‐related adverse events. Case presentation The patient was 78‐year‐old woman with adenocarcinoma who had partial response to pembrolizumab. During treatment, she complained of pollakiuria and nocturia painful micturition. Histological analysis revealed infiltration CD8‐positive and/or TIA‐1 cytotoxic granule‐associated RNA binding protein‐positive...
Background/Aim: Human gastric cancer stem-like cells (CSCs)/cancer-initiating can be identified as aldehyde dehydrogenase-high (ALDH<sup>high</sup>) cells. Cancer immunotherapy employing immune checkpoint blockade has been approved for advanced cases. However, the effectiveness of against CSCs/CICs remains unclear. This study aimed to investigate susceptibility immunotherapy. Materials and Methods: Gastric were isolated ALDH<sup>high</sup> using human cell line, MKN-45. clone...
Effective management of immune-related adverse events in patients receiving immunotherapy for cancer is problematic. In this report, we present the case a 58-year-old man with advanced clear cell renal carcinoma who responded well to combination ipilimumab and nivolumab. However, after two courses treatment, he developed fulminant hepatitis died. An autopsy confirmed that primary lesion left kidney was more than 99% necrotic only six small residual tumor lesions. These lesions were...
Abstract Immune checkpoint inhibitors (ICIs) have provided an additional treatment option for various types of human cancers. However, ICIs often induce immune‐related adverse events (irAEs). Enterocolitis is a major irAE with poorly understood histopathological characteristics. In this study, we retrospectively investigated the histopathology colon tissue samples from 17 patients treated ICIs. There were two histological patterns colitis: ulcerative colitis‐like pattern and graft vs host...
TO THE EDITOR: This is a rare case report of fungemia caused by Trichosporon dermatis in patient with refractory Burkitt's leukemia who was administered prophylactic voriconazole.
Clear cell carcinoma is a prevalent histological type of ovarian cancer in East Asia, particularly Japan, known for its resistance to chemotherapeutic agents and poor prognosis. ARID1A gene mutations, commonly found clear (OCCC), contribute pathogenesis. Recent data revealed that the mutation related better outcomes immunotherapy. Thus, this study aimed investigate immunotherapy treatment susceptibility OCCC bearing mutations.
Human cancer stem-like cells (CSCs)/cancer-initiating (CICs) can be isolated as side population (SP) cells, aldehyde dehydrogenase high (ALDHhigh) or cell surface marker-positive including CD44+ and CD133+ cells. CSCs/CICs non-CSCs/CICs are unstable in vitro culture, differentiate into some dedifferentiate CSCs/CICs. Therefore, experiments using a large amount of technically very difficult. In this study, we single clones from SP main (MP) derived the human colon line SW480. analysis...