A5065232072- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Minimally Invasive Surgical Techniques
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Neurological Disease Mechanisms and Treatments
- Gynecological conditions and treatments
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Angiogenesis and VEGF in Cancer
- Surgical Simulation and Training
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
Sapporo Medical University
2016-2024
Shibaura Institute of Technology
2022
Hakodate National Hospital
2020-2021
Future University Hakodate
2020-2021
Gunma University
1996
Abstract Recent studies have revealed that metabolic reprogramming is closely associated with epithelial‐mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) a key glycolytic enzyme highly expressed in several types of cancer. In this study, we found ALDOA uterine cervical adenocarcinoma and high expression promotes EMT to increase malignant potentials, such as metastasis invasiveness, cells. human surgical specimens, was correlated lymph node metastasis, lymphovascular...
Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression a nuclear receptor such as ERα in clinical pathology. Here, we demonstrated that cervical adenocarcinoma cells respond physiological concentration upregulate claudin-1, cell surface molecule highly expressed adenocarcinomas. Knockout claudin-1 induced apoptosis and significantly inhibited proliferation, migration, invasion tumorigenicity vivo. Importantly, all lines examined membrane-bound type...
Tight junction proteins have recently been reported to be useful for distinguishing between neoplastic and non-neoplastic tissues. In this study, we evaluated the expression localization of tight transmembrane in human cervical adenocarcinoma situ (AIS), determined whether their patterns could distinguish from glands.Fifty-five patients with or AIS were included study. Surgical specimens immunohistochemically stained claudin (CLDN) -1, -4, -7, occludin, JAM-A.Significantly higher levels...
Recent studies have revealed that aberrant expression of tight junction (TJ) proteins is a hallmark various solid tumors and it recognized as useful therapeutic target. Claudin-6 (CLDN6), member the family TJ transmembrane proteins, an ideal target because not expressed in human adult normal tissues. In this study, we found CLDN6 highly uterine cervical adenocarcinoma (ADC) high was correlated with lymph node metastasis lymphovascular infiltration independent prognostic factor. Shotgun...
Prognostic factors and therapeutic targets are needed for the patients with cervical adenocarcinoma because they have a poor prognosis. Recently, co-expression of multiple receptor tyrosine kinases (RTKs) has been found to be associated aggressive biological behavior prognosis several types malignancy. To evaluate significance expression RTKs in uterine cancers, we examined profile (EGFR, HER2 c-Met) correlation their clinicopathological features adenocarcinomas. AIS showed strong single RTK...
Uterine cervical adenocarcinoma has a worse prognosis than that of squamous cell carcinoma and useful diagnostic prognostic markers are needed. Estrogen is one the key regulators several cancers, however, estrogen signaling not been focused on in adenocarcinoma. Here, we shows expression profile classical receptor (ER) novel membrane type receptor, G protein-coupled 30 (GPR30), surgical specimens (n=53). GPR30 was strongly expressed cytoplasm situ (AIS) adenocarcinoma, its especially strong...
Abstract Recent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential various cancers. In the present study, we investigated junctional adhesion molecule‐A (JAM‐A), one transmembrane TJP, in uterine cervical adenocarcinoma and significance its for malignancy. Immunohistochemistry on human surgical specimens showed JAM‐A was aberrantly expressed neoplastic regions including situ (AIS). Knockout significantly suppressed cell...
Objectives: This study aimed to evaluate and compare the feasibility outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, assess postoperative recurrence rate overall survival patients. Methods: A retrospective review 84 who underwent for cancer (stage 1A) was conducted. Surgical procedures, patient characteristics, intraoperative measures, were statistically analyzed. single gynecologist...
We report 2 cases with a good recovery from acute kidney injury (AKI) due to exercise-induced AKI associated renal hypouricemia. Case 1 involves 20-yearold man who had similar episode year earlier. He complained of nausea, vomiting and loin pain after playing football. On admission, his serum creatinine was 3.27 mg/dl he treated intravenous fluid infusion (2 l/d). His function deteriorated rose 9.82 mg/dl. A hemodynamic evaluation using duplex Doppler ultrasound showed high arterial...
Retrospective analysis was performed to evaluate the prognostic factors for loco-regional control and results of re-irradiation 28 patients with recurrent, poorly-differentiated squamous cell carcinoma (PDSCC) nasopharynx. Twenty-four them received re-irradiation. Local, local plus regional recurrences were observed in 19, five four patients, respectively. Except three all had Stage IV disease at initial diagnosis. The only parameters influencing recurrence T N stage categories. median...
Uterine leiomyosarcoma (LMS) is a gynecological malignancy with an extremely poor prognosis. Multiple new therapeutic agents, including pazopanib, trabectedin, and eribulin, have been clinically applied to treat uterine LMS, their effects are expected. We encountered one patient advanced recurrent LMS who achieved partial response four-year treatment eribulin. A 31-year-old woman was diagnosed stage 2B LMS. After the first recurrence, Gemcitabine, Docetaxel (GD) therapy administered,...
Uterine metastases from extragenital sites are rare. We present a case of woman who had undergone surgery for small intestinal cancer and subsequently developed in her left ovary uterus. A nulliparous 50s underwent laparoscopic partial bowel resection with lymph node dissection cancer. Five months later, computed tomography (CT) revealed ovarian tumor ascites. She bilateral adnexectomy adjuvant chemotherapy, the was diagnosed as metastasis. Two years after surgery, positron emission (PET)-CT...
Abstract Aim The importance of human papillomavirus (HPV) co‐testing using physician‐, self‐, and urine‐collected samples to predict cervical intraepithelial neoplasia (CIN) grade 1–2 prognoses has not been previously reported. Therefore, this study aimed investigate outcomes patients with CIN who simultaneously underwent urine‐collection sampling tests. Methods This was conducted in Japan between October 2019 November 2022 examined the proportion cases progressions, percentage persistent...
We reviewed the results of treatment in 52 patients with hypopharyngeal carcinoma who underwent radical radiation therapy using a two-fractionation scheme-conventional fractionation (CF) and accelerated hyperfractionation (AHF)-in order to evaluate impact scheme on prognosis. The 5-year survival rate for was 19.5%, significantly better obtained AHF (44.4%) than CF (12.4%) 27 showed complete response (CR), higher CR (61%) achieved (47%). A similar trend also observed T3 T4 tumors (55% vs. 36%...
Prolactin(PRL) affects more physiological process than all other pituitary hormones combined. Normal myometrium and uterine fibroids secrete PRL, but the function of myometial PRL is unknown. We report a case complete remission hyperprolactinemia after laparoscopic myomectomy. The patient was 37 years-of-age, gravid 0, para 0. She referred to our hospital elsewhere because diagnosis with myoma. At age 35, she had been diagnosed secondary amenorrhea hyperprolactinemia. Brain MRI CT scans...
Abstract Background : The importance of human papillomavirus (HPV) co-testing using physician-, self-, and urine-collected samples to predict cervical intraepithelial neoplasia (CIN) grade 1–2 prognoses has not been previously reported. Therefore, this study aimed investigate the outcomes patients with CIN who simultaneously underwent urine-collection sampling tests. Methods This was conducted in Japan between October 2019 November 2022 examined proportion cases progressions, percentage...
Abstract Background Endometrial cancer (EC) is one of the leading causes death among women and early detection crucial for its successful treatment. We previously showed that cytological examination combined with genetic analysis using liquid-based cytology (LBC) samples improved diagnostic sensitivity EC. Methods Among 218 individuals who underwent endometrial screening by LBC, 208 were analysed cancer-panel sequencing. Excluding 13 low sequence coverage, we further 195 samples. Results...