A5044404787- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Pathogenesis and Treatment of Hiccups
- Galectins and Cancer Biology
- Immune cells in cancer
- Nonmelanoma Skin Cancer Studies
- Animal Disease Management and Epidemiology
- Neurological Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Cancer and Skin Lesions
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Dermatology and Skin Diseases
- Cardiac Arrhythmias and Treatments
- Rabies epidemiology and control
- Hematological disorders and diagnostics
- Vascular anomalies and interventions
- Inflammasome and immune disorders
- Cancer Mechanisms and Therapy
- Traumatic Ocular and Foreign Body Injuries
- Reflective Practices in Education
- Colorectal Cancer Treatments and Studies
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Wnt/β-catenin signaling in development and cancer
Osaka Ohtani University
2022-2025
Kagawa University
2025
Matsumoto Livestock Hygiene Service Center
2020-2024
Hokkaido University
2024
Hamamatsu University School of Medicine
2023
Sapporo Medical University
1996-2022
Kanagawa Children's Medical Center
2020
Kansai Medical University
1997-2020
Saitama Medical University
2004-2018
Kitano Hospital
2006-2017
Background and Purpose Although substance P ( SP ) neurokinin NK 1 receptors have been reported to be involved in cisplatin‐induced acute delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin rats, can used a model nausea humans. We investigated time‐dependent changes pica involvement this behaviour. Experimental Approach Rats were administered cisplatin with or without daily injection 5‐ HT 3 receptor antagonist (granisetron) an...
Recent studies have revealed that aberrant expression of tight junction (TJ) proteins is a hallmark various solid tumors and it recognized as useful therapeutic target. Claudin-6 (CLDN6), member the family TJ transmembrane proteins, an ideal target because not expressed in human adult normal tissues. In this study, we found CLDN6 highly uterine cervical adenocarcinoma (ADC) high was correlated with lymph node metastasis lymphovascular infiltration independent prognostic factor. Shotgun...
Despite recent advances in the immunotherapeutic intervention as second-line treatment of cervical cancer, including Pembrolizumab and Nivolumab, advanced stages disease are still associated with poor prognosis. CD47 is a macrophage checkpoint molecule overexpressed superficially nearly all cancer types that binds to its receptor on surface, leading disruption their phagocytic capacities against cells. Ezrin-Radixin-Moesin (ERM) family member proteins work scaffold by crosslinking specific...
In the past decade, immune checkpoint inhibitors have exhibited potent antitumor efficacy against multiple solid malignancies but limited pancreatic ductal adenocarcinoma (PDAC). Cluster of differentiation (CD) 47, a member immunoglobulin G superfamily, is overexpressed in surface membrane PDAC and independently correlates with worse clinical prognosis. Furthermore, CD47 functions as dominant macrophage checkpoint, providing "do not eat me" signal to enable cancer cells evade innate system....
Immune checkpoint blockade (ICB) therapies, such as immune inhibitors against programmed death ligand-1 (PD-L1), have not been successful in treating patients with pancreatic ductal adenocarcinoma (PDAC). Despite the critical role of PD-L1 various types cancers, regulatory mechanism expression on cell surface PDAC is poorly understood. Therefore, uncovering potential modulators localisation may provide a new strategy to improve ICB therapy PDAC. Here, we examined ezrin/radixin/moesin (ERM)...
ABSTRACT The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis early embryogenesis. Scaffold proteins from the ezrin-radixin-moesin (ERM) family, including neurofibromin 2 (NF2; Merlin), regulate through polarity. However, mechanisms underlying regulation via polarity establishing outer cells remain unclear. In this study, we generated artificial Nf2 mutants N-terminal FERM domain (L64P) examined activity by assessing...
We investigated the prevalence of porcine circovirus 2 (PCV2) and 3 (PCV3) in wild boars captured or found dead Nagano Prefecture 2020. Based on PCR testing, 21 254 (8.3%) were PCV2-positive 43 256 (16.8%) PCV3-positive, 5 253 (2.0%) both PCV3-positive. The frequency detecting PCV3 was significantly higher adults than juveniles (P=0.014). all districts except for North Alps Hokushin, while PCV3-positive Suwa. This is first report PCV2 detected Japan.
Nasal papules and oral ulcers were observed in calves that group-housed at a dairy farm. The diagnosed with bovine papular stomatitis (BPS) due to parapoxvirus (PPV) infection based on virologic examinations using polymerase chain reaction detect PPV. To prevent the spread of BPS, we isolated affected calves, made procedural changes so herd was managed after healthy herd, disinfected bedding slaked lime, stalls fences invert soap, changed animals' feed soft grass which does not damage...
Abstract Signet‐ring cell/histiocytoid carcinoma (SRCHC) is a very rare skin appendage cancer, with an extremely occurrence in the axilla. This study describes 11th case of SRCHC occurring axilla and reports first gene alteration analysis performed for SRCHC. An 85‐year‐old Japanese male presented tumor left Biopsy nodule demonstrated diffuse proliferation histiocytoid neoplastic cells signet‐ring dermis subcutis. Immunohistochemistry revealed loss E‐cadherin expression these cells....
一般に黄連湯を皮膚疾患に対して使用することは稀である。今回,「上熱中寒」を参考にして,黄連湯を顔面紅斑 ・紅潮に用い,有効であった5例を経験した。「上熱」や「中寒」に関して,具体的な症候はこれまであまり報告されていないが,「温まると悪化する顔面紅斑・紅潮」「赤ら顔」「ほてり」「のぼせ」「舌の黄苔」を「上熱」,「温かい飲み物を好む」「冷たい飲み物で下痢が悪化する」「他覚的な心下の冷感」を「中寒」と考えることで,黄連湯を皮膚疾患に応用することが可能であった。
Bovine leukaemia virus (BLV)-infected Holstein cattle carrying certain bovine leukocyte antigen (BoLA)-DRB3 alleles were previously shown to be resistant BLV provirus multiplication, while those other susceptible. This study aimed determine whether the BoLA-DRB3 carried by BLV-infected could predict proviral load (PVL) and peripheral blood lymphocyte (PBL) count distribution (PVL/PBL distribution).
医学的に原因を特定できない高齢者の胸腹部症状に対して大柴胡湯を中心とした処方が奏効した2例を報告する。1例目は81歳の男性。胸部圧迫感が出現し，頻度が増加したため入院して精査を行ったが明らかな異常を認めなかった。便秘，胸脇苦満を目標に大柴胡湯を投与した。3ヵ月後には胸部圧迫感が消失し，気鬱スコアやSDS も改善した。2例目は83歳の男性。多発外傷後より，心窩部痛，胸腹部圧迫感，腹部膨満感が約2年間持続していた。心窩部痛と便秘，胸脇苦満を目標に大柴胡湯を投与したところ徐々に心窩部痛，胸腹部圧迫感の症状が改善し不定期受診の回数も減少した。大柴胡湯は抑うつ症状を伴い，医学的に原因が特定できない胸腹部症状に対して考慮すべき方剤である。
ばね指は，手のA1輪状靭帯の部位に狭窄を生じ円滑な指屈伸動作が阻害されることにより発症し，西洋医学的には消炎鎮痛剤，ステロイド剤注入，手術等で治療される。今回温経湯が奏効したばね指の3症例を報告する。症例1は71歳女性。腹部膨満感に対して漢方治療中に右第3指のばね指を発症し，口唇乾燥と手足のほてりを認めた。 症例2は56歳女性。手指の多関節痛に対して漢方治療中に左第4指のばね指を発症し，手のほてりを認めた。症例3は71歳女性。慢性腎不全で加療中に，左第1指のばね指を発症した。手のほてりや口唇乾燥を認めなかったが，皮膚の枯燥感を認めた。温経湯は，手掌煩熱や口唇乾燥を使用目標としており，補血・駆瘀血作用や抗炎症作用，滋潤作用を有する生薬で構成されている。温経湯のこれらの作用が，ばね指改善に寄与した可能性がある。
症例は68歳女性，当科受診の1年前に環状肉芽腫症を発症し，トラニラストで改善傾向にあった。しかし肝障害が出現し継続困難となり，皮疹が悪化したため漢方治療を試みることとなった。のぼせ，舌，皮疹の性状から熱候が示唆され，黄連解毒湯を開始し，改善傾向にあったが，入院3日目から治癒が横ばいになった。裏寒の存在を疑い，麻黄附子細辛湯の併用を開始したところ，開始5日目から急速に肉芽の縮小を認めた。臨床的に改善を認めたことより，陽証と陰証の併存があったと考える。
症例は56歳男性。12年前より下痢・心窩部不快感・腹部膨満感を認め，過敏性腸症候群の診断で多施設にて西洋医学的加療を受けたが，改善を認めず，5年前より漢方治療を開始した。しかし漢方方剤を服用しても数日で腹部膨満感が増悪するため服薬困難であり，処方変更の度に同様のことを繰り返したため，入院加療の方針となった。腹が張る・ガスがたまるなどの持続的な腹部膨満感を認めると共に，日に数回，急激に腹が張るような，発作的な腹部膨満感が出現するため，発作的な腹部膨満感を奔豚気ととらえ苓桂甘棗湯を処方開始した。入院後速やかに発作的腹部膨満感は消失した。入院12日目に臍周囲に他覚的冷感を認め，苓桂甘棗湯の類方で寒を散じ痛みを止める良姜の加わった良枳湯に転方したところ，持続的な腹部膨満感も消失し，入院24日目に退院した。良枳湯は原典では塊痛右にあるものを治すとあるが，必ずしも右季肋部の症状を伴わずとも，奔豚気に冷えを伴う症例に良枳湯が有効である可能性が考えられる。
Thymus- and activation-regulated chemokine (TARC, also known as CCL17) is used a biomarker for atopic dermatitis. The methods currently its measurement are complex, time-consuming, require large machinery, warranting the need method that simple, has quick turnaround time, requires less complex machinery. We evaluated analytical performance of novel latex turbidimetric immunoassay method, "Nanopia TARC", on 174 residual serum samples from patients with skin or allergic diseases. This...