A5106852512- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Pregnancy-related medical research
- PI3K/AKT/mTOR signaling in cancer
- Nuclear Materials and Properties
- Fusion materials and technologies
- Nuclear reactor physics and engineering
- Coronary Interventions and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- T-cell and Retrovirus Studies
- Reproductive Physiology in Livestock
- Immune Response and Inflammation
University of Toyama
2016-2025
Shonan Kamakura General Hospital
2000-2025
Gunma University Hospital
2011-2025
Gunma University
2003-2024
Toyama University Hospital
2019-2023
Epatocentro Ticino
2023
Mount Sinai Hospital
2023
Icahn School of Medicine at Mount Sinai
2023
Japan Proton Accelerator Research Complex
2004-2022
Japan Atomic Energy Agency
2006-2021
We calculated the percentage of Th1, Th2, Th0 cells and Th1:Th2 cell ratio peripheral blood from normal pregnant subjects preeclampsia patients using flow cytometry which can analyse both surface marker, CD4, intracellular cytokines, interleukin (IL)-4 interferon (IFN)-gamma. In pregnancy, Th1 was significantly lower in third trimester, ratios were second trimester than nonpregnant subjects. contrast, higher The Th2 pregnancy. Additionally, mononuclear these cultured with phytohemagglutinin...
Summary CD4+ CD25bright regulatory T (Treg) cells have been identified as a principle regulator of tolerance during pregnancy. In the setting pre-eclampsia, however, little is known about dynamics these cells. current study, we determined Treg in peripheral blood using flow cytometry and forkhead box P3 (FoxP3+) at placental bed immunohistochemical staining. Peripheral mononuclear (PBMC) 38 pre-eclamptic cases (17 Japanese, 21 Polish), 40 normal late pregnancy subjects (20 20 non-pregnant...
Systemic manifestation of preeclampsia (PE) is associated with circulating factors, including inflammatory cytokines and damage-associated molecular patterns (DAMPs), or alarmins. However, it unclear whether the placenta directly contributes to increased levels these triggers. Here, we demonstrate that pyroptosis, a unique cell death pathway, occurs in predominantly from early onset PE, as evidenced by elevated active caspase-1 its substrate cleaved products, gasdermin D (GSDMD), IL-1β,...
Among mammalian species, human reproduction has 2 outstanding features. The hemochorial placentation is characterized by a very deep endovascular trophoblast invasion in the spiral arteries, reaching into myometrium. This requires an agonistic direct cell-cell interaction between maternal immune system and semiallogeneic trophoblast. second feature preeclampsia, heterogeneous syndrome, uniquely condition. female one of few mammals exposed to her partner's semen on multiple occasions before...
CD4+CD25high regulatory T cells (Tregs) play a critical role in self-tolerance, as seen murine autoimmunity. Studies on Tregs human autoimmunity have focused primarily peripheral blood samples. A study targeting diseased tissue should identify direct relationships between and Peripheral samples were collected from 91 patients with primary biliary cirrhosis (PBC), 28 immediate relatives, 41 healthy controls, Treg frequencies determined percentage of CD4+TCR-αβ+ cells. tissue-targeted...
Journal Article Cytokine production by CD16–CD56bright natural killer cells in the human early pregnancy decidua Get access Shigeru Saito, Saito 1Department of Obstetrics and Gynecology, Nara Medical University840, Shijo-cho, Kashihara-shi, 634, Japan Correspondence to: S. Search for other works this author on: Oxford Academic PubMed Google Scholar Kiyoshi Nishikawa, Nishikawa 2Second Department Internal Medicine, Takeshi Morii, Morii Masahiro Enomoto, Enomoto Nobuhiro Narita, Narita Kazuo...
To examine whether preeclampsia involves type-1 T-helper (TH1) immune hyperactivity.Expression of HLA-DR, a cell-surface marker activation, was analyzed on CD3+, CD4+, and CD8+ T cells in 15 preeclamptic patients normal pregnant women using flow cytometry. Additionally, peripheral blood mononuclear from were cultured with or without phytohemagglutinin (PHA) stimulation, interleukin (IL)-2, IL-4, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha concentrations determined the...
Abstract Clinical guidelines for obstetrical practice were first published by the Japan Society of Obstetrics and Gynecology (JSOG) Association Obstetricians Gynecologists (JAOG) in 2008, a revised version was 2011. The aims this publication include determination current standard care practices pregnant women Japan, widespread use practices, enhancement safety practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding between maternity‐service...
In early pregnancy, trophoblasts and the fetus experience hypoxic low-nutrient conditions; nevertheless, invade uterine myometrium up to one third of its depth migrate along lumina spiral arterioles, replacing maternal endothelial lining. Here, we showed that autophagy, an intracellular bulk degradation system, occurred in extravillous trophoblast (EVT) cells under hypoxia vitro vivo. An enhancement autophagy was observed EVTs placental tissues, which suffer from physiological hypoxia. The...